Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum

Principles and Practice of Infectious Diseases.

1991 • 12,590 citations

Experimental bacterial endocarditis. I. Colonization of a sterile vegetation.

1972 • 361 citations

Comparative Antibiotic Dose-Effect Relations at Several Dosing Intervals in Murine Pneumonitis and Thigh-Infection Models

1989 • 352 citations

Once versus thrice daily gentamicin in patients with serious infections

1993 • 351 citations

Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart.

1970 • 304 citations

Single, Large, Daily Dosing Versus Intermittent Dosing of Tobramycin for Treating Experimental Pseudomonas Pneumonia

1988 • 204 citations

Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart.

1971 • 191 citations

Antimicrobial Treatment of Infective Endocarditis due to Viridans Streptococci, Enterococci, and Staphylococci

1989 • 162 citations

Once-daily dosing regimen for aminoglycoside plus β-Lactam combination therapy of serious bacterial infections: Comparative trial with netilmicin plus ceftriaxone

1990 • 151 citations

Antibiotic Therapy of Infections Due to Pseudomonas aeruginosa in Normal and Granulocytopenic Mice: Comparison of Murine and Human Pharmacokinetics

1986 • 116 citations

Netilmicin in the Treatment of Gram-Negative Bacteremia: Single Daily versus Multiple Daily Dosage

1989 • 102 citations

The Influence of Tobramycin Dosage Regimens on Nephrotoxicity, Ototoxicity, and Antibacterial Efficacy in a Rat Model of Subcutaneous Abscess

1988 • 88 citations

Pharmacokinetic and toxicological evaluation of a once-daily regimen versus conventional schedules of netilmicin and amikacin

1991 • 82 citations

Importance of the aminoglycoside dosing regimen in the penicillin-netilmicin combination for treatment of Enterococcus faecalis-induced experimental endocarditis

1990 • 76 citations

Integration of pharmacokinetics and pharmacodynamics of imipenem in a human-adapted mouse model

1991 • 65 citations

Postantibiotic effect of penicillin plus gentamicin versus Enterococcus faecalis in vitro and in vivo

1989 • 54 citations

Efficacy and safety of amikacin in systemic infections when given as a single daily dose or in two divided doses

1991 • 45 citations

Simulation of amoxicillin pharmacokinetics in humans for the prevention of streptococcal endocarditis in rats

1994 • 36 citations

Once-daily versus thrice-daily administration of netilmicin in combination therapy ofPseudomonas aeruginosa infection in a man-adapted neutropenic animal model

1989 • 31 citations

Simulated human serum profiles of one daily dose of ceftriaxone plus netilmicin in treatment of experimental streptococcal endocarditis

1993 • 29 citations

Optimal aminoglycoside dosing regimen for penicillin-tobramycin synergism in experimental Streptococcus adjacens endocarditis

1992 • 29 citations

Effect of gentamicin dosing interval on therapy of viridans streptococcal experimental endocarditis with gentamicin plus penicillin

1995 • 22 citations

Influence of Dosage Regimen on Experimental Tobramycin Nephrotoxicity

1983 • 22 citations

Relation of Dosing Regimen to Aminoglycoside Ototoxicity: Evaluation of Auditory Damage in the Guinea Pig

1990 • 20 citations

Simulation of human serum pharmacokinetics of cefazolin, piperacillin, and BRL 42715 in rats and efficacy against experimental intraperitoneal infections

1992 • 18 citations

Simulation of human serum pharmacokinetics of ticarcillin-clavulanic acid and ceftazidime in rabbits, and efficacy against experimental Klebsiella pneumoniae meningitis

1989 • 18 citations

Influence of the pre-treatment duration of infection on the efficacies of various antibiotic regimens in experimental streptococcal endocarditis

1993 • 17 citations

Simulation of human pharmacokinetic profiles in mice, and impact on antimicrobial efficacy of netilmicin, ticarcillin and ceftazidime in the peritonitis-septicemia model.

1990 • 15 citations

Temocillin efficacy in experimental Klebsiella pneumoniae meningitis after infusion into rabbit plasma to simulate antibiotic concentrations in human serum

1988 • 13 citations

COMPARISON OF THE POST‐ANTIBIOTIC EFFECT OF STREPTOCOCCUS FAECALIS AND STREPTOCOCCUS FAECIUM WITH AMPICILLIN ALONE OR COMBINED WITH STREPTOMYCIN: STUDIES ON A NOVEL TYPE OF ANTIMICROBIAL INTERACTION

1987 • 8 citations

Evaluation of the combination effects of ampicillin or vancomycin combined with streptomycin, gentamicin, tobramycin or netilmicin against enterococci

1989 • 8 citations

Efficacy of antimicrobial agent treatment in relation to treatment regimen: experimental models and clinical evaluation

1993 • 7 citations