Cyclin Proteolysis as a Retinoid Cancer Prevention Mechanism

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers

1994 • 4,626 citations

Effects of a Combination of Beta Carotene and Vitamin A on Lung Cancer and Cardiovascular Disease

1996 • 3,608 citations

Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation

1999 • 2,990 citations

A decade of molecular biology of retinoic acid receptors

1996 • 2,893 citations

Lack of Effect of Long-Term Supplementation with Beta Carotene on the Incidence of Malignant Neoplasms and Cardiovascular Disease

1996 • 2,429 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN

1925 • 1,630 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.

1992 • 1,200 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).

1976 • 993 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Recent Advances in Chemoprevention of Cancer

1997 • 837 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

Nuclear receptor coactivators

1997 • 720 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

1996 • 659 citations

Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid

1992 • 583 citations

Prevention of Skin Cancer in Xeroderma Pigmentosum with the Use of Oral Isotretinoin

1988 • 578 citations

Suppression of Retinoic Acid Receptor–β in Premalignant Oral Lesions and Its Up-Regulation by Isotretinoin

1995 • 419 citations

Randomized Trial of Fenretinide to Prevent Second Breast Malignancy in Women With Early Breast Cancer

1999 • 416 citations

Adjuvant treatment of stage I lung cancer with high-dose vitamin A.

1993 • 353 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Prevention of Second Primary Tumors by an Acyclic Retinoid, Polyprenoic Acid, in Patients with Hepatocellular Carcinoma

1998 • 324 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element.

1989 • 306 citations

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

1992 • 280 citations

Enhancement of Regression of Cervical Intraepithelial Neoplasia II (Moderate Dysplasia) With Topically Applied All- trans -Retinoic Acid: a Randomized Trial

1994 • 273 citations

N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid.

1993 • 249 citations

Involvement of Reactive Oxygen Species in N-(4-Hydroxyphenyl)retinamide-Induced Apoptosis in Cervical Carcinoma Cells

1997 • 226 citations

Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism

1997 • 201 citations

Retinoic Acid Promotes Ubiquitination and Proteolysis of Cyclin D1 during Induced Tumor Cell Differentiation

1999 • 163 citations

Aberrant expression of p53 or the epidermal growth factor receptor is frequent in early bronchial neoplasia and coexpression precedes squamous cell carcinoma development.

1995 • 146 citations

Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.

1993 • 143 citations

Targeted Disruption of Retinoic Acid Receptor α (RARα) and RARγ Results in Receptor-Specific Alterations in Retinoic Acid-Mediated Differentiation and Retinoic Acid Metabolism

1995 • 143 citations

Role of antioxidants and intracellular free radicals in retinamide- induced cell death

1997 • 133 citations

Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development.

1999 • 124 citations

Distinct Retinoid X Receptor-Retinoic Acid Receptor Heterodimers Are Differentially Involved in the Control of Expression of Retinoid Target Genes in F9 Embryonal Carcinoma Cells

1997 • 117 citations

The Retinoids and Cancer Prevention Mechanisms

2000 • 111 citations

Identification of retinoids with nuclear receptor subtype-selective activities.

1991 • 105 citations

Cyclin D1 Proteolysis: a Retinoid Chemoprevention Signal in Normal, Immortalized, and Transformed Human Bronchial Epithelial Cells

1999 • 101 citations

Inhibited transformation of immortalized human bronchial epithelial cells by retinoic acid is linked to cyclin E down-regulation.

1996 • 84 citations

Response and resistance to retinoic acid are mediated through the retinoic acid nuclear receptor gamma in human teratocarcinomas.

1994 • 54 citations

4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARγ independent pathway

1999 • 51 citations

Overexpression of the retinoic acid receptor gamma directly induces terminal differentiation of human embryonal carcinoma cells.

1995 • 42 citations

Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells

1998 • 35 citations

The Retinoids: Cancer Therapy and Prevention Mechanisms

1999 • 30 citations

Derivation and characterization of retinoid-resistant human embryonal carcinoma cells

1996 • 22 citations