Targeting of N-(2-Hydroxypropyl)Methacrylamide Copolymer-Doxorubicin Conjugate to the Hepatocyte Galactose-Receptor in Mice: Visualisation and Quantification by Gamma Scintigraphy as a Basis for Clinical Targeting Studies

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Drug-polymer conjugates

1992 • 441 citations

Effect of molecular weight (M_w) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

1987 • 428 citations

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycinImmunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1989 • 196 citations

Reduction-mediated technetium-99m labeling of monoclonal antibodies.

1990 • 168 citations

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1986 • 133 citations

The pharmacokinetics of polymer-bound adriamycin

1990 • 121 citations

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1991 • 116 citations

The role of extra-hepatic tissues in the receptor-mediated plasma clearance of glycoproteins terminated by mannose or N-acetylglucosamine

1980 • 81 citations

Reduced cardiotoxicity of doxorubicin given in the form ofN-(2-hydroxypropyl) methacrylamide conjugates: an experimental study in the rat

1991 • 77 citations

Effect of galactose on interaction ofN-(2-hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: Preliminary application to an anticancer agent, daunomycin

1989 • 43 citations

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat

1991 • 35 citations

Technetium-99m-labeled monoclonal antibodies for immunoscintigraphy

1991 • 33 citations

111In labelling of a branched polypeptide drug carrier with a poly(l-lysine) backbone

1992 • 17 citations

Biodistribution and tumour localization of radiolabelled monoclonal antibody during continuous infusion in nude mice and with human tumour xenografts

1987 • 15 citations

Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier

1992 • 15 citations

Demonstration of the hepatic uptake of radiolabelled immunotoxins using gamma scintigraphy

1987 • 9 citations