Synthesis of pyrazolo 3,4-pyrimidine analogues of the potent agent N-4-2-2-amino-4 3-oxo-7-pyrrolo 2,3-pyrimidin-5-yl ethylbenzoyl-L-glutamic acid (LY231514)

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1981 • 242 citations

Potential Purine Antagonists. I. Synthesis of Some 4,6-Substituted Pyrazolo [3,4-d] pyrimidines¹

1956 • 241 citations

Carbonsäurederivate, V. Substituierte Dithiocarbonsäuren und Ketenmercaptale

1962 • 207 citations

The renewed potential for folate antagonists in contemporary cancer chemotherapy

1991 • 151 citations

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

1991 • 78 citations

Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C-2 position

1990 • 74 citations

Convergent and efficient palladium-effected synthesis of 5, 10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

1989 • 68 citations

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

1989 • 63 citations

New pathways from pteridines. Design and synthesis of a new class of potent and selective antitumor agents

1990 • 61 citations

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.

1990 • 61 citations

Reaction of nitriles under acidic conditions. Part I. A general method of synthesis of condensed pyrimidines

1980 • 58 citations

Synthesis of 2′‐Deoxyribofuranosides of 8‐Aza‐7‐deazaguanine and Related Pyrazolo[3,4‐d]pyrimidines

1986 • 45 citations

Syntheses and thymidylate synthase inhibitory activity of the poly-.gamma.-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates

1992 • 33 citations

Potential Purine Antagonists. IX. Further Studies of Some 4,6-Disubstituted Pyrazolo[3,4-d]pyrimidines¹

1957 • 29 citations

Potential Purine Antagonists VII. Synthesis of 6-Alkylpyrazolo-[3,4-d]pyrimidines^1,2a

1958 • 28 citations

Synthesen stickstoffhaltiger Heterocyclen, XL. Synthesen von Pyrazolo‐pyrimidinen aus neuen Pyrazol‐ und Pyrimidin‐Derivaten

1967 • 25 citations

Synthesis of quinazoline analogs of isofolic acid

1975 • 20 citations

Synthesis of the b-D-Deoxyribofuranoside of 6-Amino-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one — A New Isoster of 2'-Deoxyguanosine

1985 • 16 citations

Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogs in the C2-methyl series

1991 • 13 citations