H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes

1974 • 572 citations

The in vitro generation and sustained culture of nude mouse cytolytic T-lymphocytes.

1979 • 268 citations

The Influence of Thymus H-2 Antigens on the Specificity of Maturing Killer and Helper Cells

1978 • 257 citations

T-cell-derived helper factor allows in vivo induction of cytotoxic T cells in nu/nu mice

1980 • 228 citations

Responsiveness to HY Antigen Ir Gene Complementation and Target Cell Specificity

1977 • 215 citations

Regulation by the H-2 gene complex of macrophage-lymphoid cell interactions in secondary antibody responses in vitro.

1976 • 176 citations

Role of H‐2 Gene Products in the Function of T Helper Cells from Normal and Chimeric Mice in Vivo¹

1978 • 153 citations

Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus grafts.

1980 • 139 citations

Specific Unresponsiveness of Recirculating Lymphocytes after Exposure to Histocompatibility Antigen in F1 Hybrid Rats

1971 • 109 citations

In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 type.

1978 • 108 citations

Quantitative Studies of the Activation of Cytotoxic Lymphocyte Precursor Cells

1977 • 100 citations

Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.

1977 • 92 citations

T-T cell interactions during in vitro cytotoxic T lymphocyte (CTL) responses. II. Helper factor from activated Lyt 1+ T cells is rate limiting i) in T cell responses to nonimmunogenic alloantigen, ii) in thymocyte responses to allogeneic stimulator cells, and III) recruits allo- or H-2-restricted CTL precursors from the Lyt 123+ T subset.

1980 • 88 citations

Adaptive differentiation of murine lymphocytes. I. Both T and B lymphocytes differentiating in F1 transplanted to parental chimeras manifest preferential cooperative activity for partner lymphocytes derived from the same parental type corresponding to the chimeric host.

1978 • 84 citations

The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

1977 • 78 citations

In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells

1978 • 62 citations

In vivo sensitization of T cells to hapten‐conjugated syngeneic structures of major histocompatibility complex. I. Effect of in vitro culture upon generation of cytotoxic T lymphocytes

1976 • 58 citations

Limiting dilution analysis of alloantigen-reactive T lymphocytes. II. Effect of cortisone and cyclophosphamide on cytolytic T lymphocyte precursor frequencies in the thymus.

1979 • 48 citations

T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

1978 • 42 citations

Studies on the generation and expression of H‐2‐controlled T helper function in chimeric mice: Evidence for two levels of H‐2 restriction

1979 • 40 citations

Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.

1979 • 39 citations

T cell‐mediated cytotoxic immune responsiveness of chimeric mice bearing a thymus graft fully allogeneic to the graft of lymphoid stem cells

1980 • 31 citations

Influence of the Major Histocompatibility Complex on T-Cell Activation

1979 • 30 citations

Patterns of virus-immune T-cell responsiveness. Comparison of (H-2(k) x H-2(b)) {arrow} H-2(b) Radiation Chimeras and negatively selected H-2(b) lymphocytes

1979 • 23 citations

T‐T cell interactions during in vitro cytotoxic T lymphocyte responses. III. Antigen‐specific T helper cells release nonspecific mediator(s) able to help induction of H‐2‐restricted cytotoxic T lymphocyte responses across cell‐impermeable membranes

1980 • 23 citations

T cells recognize minor histocompatibility antigens on H-2 allogeneic cells.

1979 • 23 citations

Primary in vitro sensitization of virus specific cytotoxic T lymphocytes.

1978 • 15 citations

Lymphocytes which differentiate in an allogeneic thymus

1980 • 9 citations