Topoisomerase inhibitors potentiate the effect of retinoic acid on cell growth inhibition and induction of differentiation of leukemia HL-60 cells

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Topoisomerase-targeting antitumor drugs

1989 • 441 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells

1986 • 168 citations

Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients.

1984 • 149 citations

Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.

1989 • 69 citations

Retinoic acid‐induced differentiation of the human promyelocytic leukemia cell line, HL‐60, and fresh human leukemia cells in primary culture: A model for differentiation inducing therapy of leukemia

1987 • 65 citations

Topoisomerase Inhibitors Have Potent Differentiation‐inducing Activity for Human and Mouse Myeloid Leukemia Cells

1991 • 52 citations

Synergistic induction of the differentiation of WEHI-3B D+ myelomonocytic leukemia cells by retinoic acid and granulocyte colony-stimulating factor

1992 • 34 citations

Modulation of retinoic acid-induced differentiation of human leukemia (HL-60) cells by serum factors and sphinganine.

1990 • 34 citations

Induction of differentiation of human and mouse myeloid leukemia cells by camptothecin

1990 • 33 citations

Induction of granulocytic maturation in acute myeloid leukemia by G-CSF and retinoic acid

1991 • 31 citations

The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells

1992 • 16 citations

The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells

1992 • 11 citations

Purification of a low molecular weight factor that induces differentiation and inhibits growth in myeloid leukemia cells.

1988 • 8 citations