Peripheral administration of hypothalamic peptides results in CNS changes

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

1976 • 811 citations

The Regional Distribution of Somatostatin in the Rat Brain

1975 • 594 citations

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

1970 • 546 citations

Induction of Mating Behavior in Rats by Luteinizing Hormone-Releasing Factor

1973 • 533 citations

Luteinizing Hormone-Releasing Factor Potentiates Lordosis Behavior in Hypophysectomized Ovariectomized Female Rats

1973 • 512 citations

Somatostatin: Abundance of Immunoreactive Hormone in Rat Stomach and Pancreas

1975 • 475 citations

Thyrotropin-Releasing Hormone (TRH): Distribution in Hypothalamic and Extrahypothalamic Brain Tissues of Mammalian and Submammalian Chordates

1974 • 473 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

Thyrotropin-Releasing Hormone: Regional Distribution in Rat Brain

1974 • 421 citations

Thyrotropin-Releasing Hormone in Specific Nuclei of Rat Brain

1974 • 378 citations

Regional distribution of leu and met enkephalin in rat brain

1977 • 307 citations

Distribution and Concentration of TRH in the Rat Brain¹²

1974 • 300 citations

Thyrotropin Releasing Hormone: Enhancement of Dopa Activity by a Hypothalamic Hormone

1972 • 283 citations

Neurotensin: Central nervous system effects of a hypothalamic peptide

1977 • 260 citations

β-Endorphin-Induced Changes in Schizophrenic and Depressed Patients

1977 • 253 citations

Anatomical Neuroendocrinology

1978 • 242 citations

Isolation and structure of hypothalamic MSH release-inhibiting hormone

1971 • 219 citations

Substance P and analgesia

1976 • 202 citations

The Thymus and Autoimmunity

1967 • 188 citations

DOPA Potentiation by a hypothalamic factor, MSH release-inhibiting hormone (MIF)

1971 • 185 citations

β-Endorphin and male sexual behavior

1977 • 171 citations

The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the rat.

1955 • 167 citations

An Analog of Enkephalin Having Prolonged Opiate-Like Effects in Vivo

1977 • 159 citations

Neuroregulators and Psychiatric Disorders

1978 • 158 citations

Polypeptide influences on attention, memory and anxiety in man

1974 • 145 citations

CENTRAL NERVOUS SYSTEM EFFECTS OF HYPOTHALAMIC PEPTIDES

1975 • 143 citations

Affective State and Thyrotropin and Prolactin Responses After Repeated Injections of Thyrotropin-Releasing Hormone in Depressed Patients

1974 • 142 citations

Somatostatin and thyrotropin releasing hormone: Central effect on sleep and motor system

1976 • 141 citations

Substance P

1974 • 138 citations

Induction of excessive grooming in the rat by fragments of lipotropin

1976 • 136 citations

Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin

1976 • 128 citations

Enkephalin and a potent analog facilitate maze performance after intraperitoneal administration in rats

1976 • 127 citations

The effect of adrenocorticotrophic hormone (ACTH) on avoidance conditioning in the adrenalectomized rat.

1962 • 126 citations

Influence of neonatal injections of α-MSH on learning, memory and attention in rats

1977 • 120 citations

Putative Peptide Neurotransmitters

1977 • 114 citations

Psycho-physiologic correlates of MSH activity in man

1971 • 112 citations

Protirelin Stimulation Test and Thyroid Function During Treatment of Depression

1975 • 111 citations

The Half-life, Metabolism and Excretion of Tritiated Luteinizing Hormone-Releasing Hormone (LH-RH) in Man

1973 • 110 citations

Distribution of 3H-α-MSH in rat brain

1976 • 110 citations

Neurobiology of Sleep and Memory

1977 • 108 citations

Enhancement of attention in man with ACTH/MSH 4–10

1975 • 104 citations

Localization of growth hormone‐release‐inhibiting hormone (somatostatin) in the rat brain

1975 • 100 citations

Neuropharmacological actions of enkephalin after systemic administration

1976 • 99 citations

Melanocyte-Stimulating Hormone-Release Inhibiting Hormone as an Antidepressant

1974 • 96 citations

Studies on the influence of biogenic amines and psychoactive drugs on the prognostic value of the TRH stimulation test in endogenous depression

1977 • 96 citations

MSH/ACTH 4-10 Influences Behavioral and Physiological Measures of Attention¹

1977 • 95 citations

Neuroendocrine influences on visual discrimination and reversal learning in the albino and hooded rat

1973 • 94 citations

Blood-brain barrier, half-time disappearance, and brain distribution for labeled enkephalin and a potent analog

1976 • 94 citations

PSYCHOTROPIC ACTION OF HORMONES

1978 • 87 citations

Enhancement of attention in man with ACTH/MSH 4–10

1975 • 83 citations

EXTRAPIGMENTARY EFFECTS OF MELANOCYTE-STIMULATING HORMONE IN AMENORRHŒIC WOMEN

1968 • 82 citations

How ACTH acts on the brain

1977 • 81 citations

Prostaglandin Levels in Tissues of the Male Reproductive System in Six Strains of Mice

1975 • 81 citations

POTENTIATION OF LEVODOPA EFFECT BY INTRAVENOUS L-PROLYL-L-LEUCYL-GLYCINE AMIDE IN MAN

1975 • 80 citations

Differences in the degradation of hypothalamic releasing factors by rat and human serum

1976 • 79 citations

Dorsal hippocampus: A site of action of neuropeptides on avoidance behavior?

1976 • 78 citations

On the Half Life of Thyrotropin-Releasing Hormone in Rats

1972 • 75 citations

Dopamine Synthesis: Stimulation by a Hypothalamic Factor

1973 • 74 citations

Deserpidine Antagonism by a Tripeptide, L-Prolyl-L-Leucylglycinamide

1973 • 73 citations

The fate of C14-dihydroxyphenylalanine (C14-dopa) in the whole mouse.

1970 • 73 citations

DOPA Potentiation in Ablated Animals and Brain Levels of Biogenic Amines in Intact Animals after Prolyl-leucylglycinamide

1974 • 73 citations

Neuropeptide MSH/ACTH 4–10 enhances attention in the mentally retarded

1976 • 73 citations

The Pituitary-Adrenocortical System in Avoidance Learning

1955 • 71 citations

Inactivation of somatostatin (GH‐RIH) and its analogs by crude and partially purified rat brain extracts

1975 • 70 citations

Neuroheptapeptide influence on attention and memory in man

1976 • 70 citations

Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

1975 • 68 citations

Distribution, Half-Life, and Excretion of <sup>14</sup>C- and <sup>3</sup>H-Labeled L-Prolyl-L-Leucyl-GIycinamide in the Rat

1973 • 66 citations

α-MSH and MIF-I effects on catecholamine levels and synthesis in various rat brain areas

1975 • 65 citations

Effect of Melanocyte-Stimulating Hormone-Release Inhibiting Factor (MIF) in Parkinson’s Syndrom

1974 • 62 citations

Action of two hypothalamic factors (TRH, MIF) and of angiotensin II on the behavioral effects of L-DOPA and 5-hydroxytryptophan in mice

1974 • 61 citations

Hypothalamic Releasing Factors and Parkinson Disease

1974 • 60 citations

Growth hormone release inhibiting hormone: Neuropharmacological studies

1974 • 56 citations

Thyroid stimulating hormone response after thyrotropin releasing hormone in depressed, schizophrenic and normal women

1977 • 56 citations

Production of MSH-release-inhibiting hormone by a particulate preparation of hypothalami: Mechanisms of oxytocin inactivation

1973 • 56 citations

Endorphin analogs with potent and long-lasting analgesic effects

1977 • 54 citations

Antagonism of the analeptic activity of thyrotropin-releasing hormone (TRH) by agents which enhance GABA transmission

1977 • 54 citations

Peptides with Morphine-like Action in the Brain

1977 • 54 citations

Peptides readily penetrate the blood-brain barrier: Uptake of peptides by synaptosomes is passive

1976 • 52 citations

Intensification of central catecholaminergic and serotonergic processes by the hypothalamic factors MIF and TRF and by angiotensin II

1975 • 49 citations

Distribution and metabolism of <scp>dl</scp>-3,4-dihydroxy[2-14C]-phenylalanine in rat tissues

1964 • 47 citations

Hypothalamic releasing factors: Physiological evidence for a regulatory action on central neurons and pathways for their distribution in brain

1976 • 47 citations

Investigations on α-MSH and MIF-I effects on cyclic AMP levels in rat brain

1976 • 44 citations

Thyrotropin-releasing hormone: differential antidepressant and endocrinological effects

1976 • 44 citations

Enhancement of Locomotor Activity and Catecholamine and 5-Hydroxytryptamine Metabolism by Thyrotropin Releasing Hormone

1977 • 41 citations

A DOUBLE BLIND CROSS OVER TRIAL OF GONADOTROPHIN RELEASING HORMONE (LHRH) IN SEXUALLY IMPOTENT MEN

1976 • 41 citations

β‐ENDORPHIN: SYNTHESIS AND MORPHINE‐LIKE ACTIVITY OF ANALOGS WITH D‐AMINO ACID RESIDUES IN POSITIONS 1, 2, 4 AND 5

1977 • 40 citations

Increased acquisition of a complex appetitive task after MSH and MIF

1975 • 38 citations

Oxotremorine antagonism by prolyl-leucyl-glycine-amide administered by different routes and with several anticholinergics

1974 • 38 citations

Brain peptides with opiate antagonist action: Their possible role in tolerance and dependence

1977 • 36 citations

MSH affects regional perfusion of the brain

1975 • 36 citations

Psychoendocrinological and therapeutic effects of TRH in depression

1977 • 35 citations

Breakdown of enkephalin and endorphin analogs by brain extracts

1977 • 35 citations

Neonatal treatment with TRH affects development, learning, and emotionality in the rat

1976 • 34 citations

Biodegradation of α-MSH and derived peptides by rat brain extracts, and by rat and human serum

1976 • 34 citations

Effects of α-MSH on motivation, vigilance and brain respiration

1976 • 32 citations

DISAPPEARANCE OF LH‐RELEASING HORMONE IN MAN AS DETERMINED BY RADIOIMMUNOASSAY

1974 • 31 citations

The Disappearance, Excretion, and Metabolism of Tritiated Prolyl-Leucyl-Glycinamide in Man

1974 • 29 citations

Influence of three short-chain peptides (α-MSH, MSH/ACTH 4–10, MIF-I on) dimensional attention

1976 • 28 citations

Neuropharmacological tests with α-melanocyte stimulating hormone

1976 • 28 citations

Comparison of the analeptic potency of TRH, ACTH 4–10, LHRH, and related peptides

1976 • 27 citations

Studies on the inhibition of oxotremorine induced tremor by a melanocyte‐stimulating hormone release‐inhibiting factor, thyrotropin releasing hormone and related peptides

1974 • 27 citations

On the optimal dosage of Pro-Leu-Gly-NH2 (MIF) in neuropharmacological tests and clinical use

1977 • 27 citations

Effects of L-prolyl-L-leucyl-glycine amide (MIF-I) on dopaminergic neurons

1976 • 26 citations

Melanin in the rat brain

1976 • 25 citations

Clinical investigations for emotional effects of neuropeptide hormones

1976 • 25 citations

Sexual Impotence: a Double-Blind Study of LHRH Nasal Spray versus Placebo

1975 • 22 citations

MSH/ACTH4–10 influences on the CAR in human subjects: A negative finding

1977 • 19 citations

Thyrotropin‐Releasing Hormone (TRH) in chronic schizophrenia: A CONTROLLED STUDY

1977 • 15 citations

Effects of ACTH and zinc phosphate vehicle on shuttlebox CAR

1970 • 14 citations

[Infusion therapy with mif (melanocyte inhibiting factor) in Parkinson's disease (author's transl)].

1975 • 14 citations

9th International symposium on parkinson's disease

1987 • 13 citations

INACTIVATION OF THYROTROPHIN RELEASING HORMONE BY HUMAN AND RAT SERUM

1977 • 13 citations

Inactivation of thyrotrophin releasing hormone (TRH) by peptidase in different areas of the rabbit brain

1976 • 13 citations

Antagonism of isolation-induced aggression in mice by thyrotropin-releasing hormone (TRH)

1976 • 12 citations

Comparison of the regulation of rotational behavior by hypothalamic oligopeptides

1977 • 10 citations

β-endorphin: Dose-dependent suppression of fixed-ratio operant behavior

1977 • 10 citations

Lack of effect of chronically administered thyrotropin-releasing hormone (TRH) on regional rat brain tyrosine hydroxylase activity

1977 • 8 citations

Natriuresis after water loading in rats bearing transplants of pars intermedia

1977 • 7 citations

Local degradation of growth hormone-release-inhibiting hormone (somatostatin) in the central nervous system

1977 • 6 citations

Comparison of thyrotropin-releasing hormone with melanocyte-stimulating-hormone-release-inhibiting factor as pentobarbital antagonists in monkeys

1977 • 6 citations