Herpes Simplex Virus Immunology: Problems, Progress, and Promises

Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.

1978 • 744 citations

Antibody-enhanced dengue virus infection in primate leukocytes

1977 • 549 citations

The Natural History of Herpes Simplex Virus Infection of Mother and Newborn

1980 • 467 citations

Macrophages and Age-Dependent Resistance to Herpes Simplex Virus in Mice

1970 • 282 citations

Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses.

1976 • 246 citations

Cell-mediated cytotoxicity against virus-infected target cells in humans. II. Interferon induction and activation of natural killer cells.

1978 • 216 citations

THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS

1964 • 215 citations

Selective Effects of Anti-Macrophage Serum, Silica and Anti-Lymphocyte Serum on Pathogenesis of Herpes Virus Infection of Young Adult Mice

1970 • 211 citations

RESTRICTION OF HERPES SIMPLEX VIRUS BY MACROPHAGES

1971 • 174 citations

Impaired production of gamma-interferon by newborn cells in vitro is due to a functionally immature macrophage.

1985 • 172 citations

Relationship of Antibody to Outcome in Neonatal Herpes Simplex Virus Infections

1980 • 162 citations

Lymphocyte Interferon Production and Transformation after Herpes Simplex Infections in Humans

1974 • 156 citations

Natural Killing of Herpes Simplex Virus Type 1-Infected Target Cells: Normal Human Responses and Influence of Antiviral Antibody

1979 • 156 citations

Protection of Mice from Fatal Herpes Simplex Virus Type 1 Infection by Adoptive Transfer of Cloned Virus-specific and H-2-restricted Cytotoxic T Lymphocytes

1983 • 149 citations

Thymus dependence of viral antigens

1975 • 145 citations

The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes.

1977 • 136 citations

Detection of cell-dependent cytotoxic antibody to cells infected with herpes simplex virus

1974 • 129 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Cell-mediated immunity against herpes simplex induction of cytotoxic T lymphocytes

1980 • 103 citations

Cellular Immune Response in Genital Herpes Simplex Virus Infection

1978 • 99 citations

gamma Interferon production appears to predict time of recurrence of herpes labialis.

1983 • 99 citations

Immunobiology of herpes simplex virus infection

1984 • 97 citations

Possible role of Fc receptors on cells infected and transformed by herpesvirus: escape from immune cytolysis

1978 • 92 citations

Cell-mediated immunity in herpes simplex virus-infected mice: H-2 mapping of the delayed-type hypersensitivity response and the antiviral T cell response.

1981 • 91 citations

Cell-mediated immune responses in patients with recurrent Herpes Simplex infections. II. Infection-associated deficiency of lymphokine production in patients with recurrent herpes labialis or herpes progenitalis.

1977 • 88 citations

Experimental Infection of Inbred Mice with Herpes Simplex Virus: II. Interferon Production and Activation of Natural Killer Cells in the Peritoneal Exudate

1981 • 88 citations

Effects of Immunostimulants on Resistance of Newborn Mice to Herpes Simplex Type 2 Infection

1976 • 87 citations

Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice

1979 • 84 citations

Experimental Infection of Inbred Mice with Herpes Simplex Virus Type 1. I. Investigation of Humoral and Cellular Immunity and of Interferon Induction

1981 • 80 citations

Protection of neonatal mice against herpes simplex virus infection: probable in vivo antibody-dependent cellular cytotoxicity.

1982 • 75 citations

Newborn infection with Herpesvirus hominis types 1 and 2

1969 • 74 citations

Effect of acyclovir treatment of primary genital herpes on the antibody response to herpes simplex virus.

1984 • 69 citations

Host Defenses in the Human Neonate

1977 • 68 citations

Sequential Changes in Cell-Mediated Immune Responses to Herpes Simplex Virus After Recurrent Herpetic Infection in Humans

1977 • 62 citations

Depressed specific cell-mediated immunity to Herpes simplex virus type 1 in patients with recurrent herpes labialis

1975 • 61 citations

Specific lymphocyte blastogenic responses in children with cytomegalovirus and herpes simplex virus infections acquired early in infancy

1981 • 61 citations

Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans.

1978 • 58 citations

Specific immunity after congenital or neonatal infection with cytomegalovirus or herpes simplex virus.

1984 • 58 citations

Augmentation of immunity to herpes simplex virus by in vivo administration of interleukin 2.

1985 • 58 citations

Immunobiology of Infection With Herpes Simplex Virus

1982 • 55 citations

Human T-cell cultures from virus-sensitized donors can mediate virus-specific and HLA-restricted cell lysis

1980 • 55 citations

Interferon induction of natural killer cytotoxicity in human neonates

1981 • 51 citations

Antibody-Dependent Cellular Cytotoxicity to Target Cells Infected With Herpes Simplex Viruses: Functional Adequacy in the Neonate

1977 • 49 citations

Genetics of macrophage-controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice

1977 • 48 citations

Analysis in Human Neonates of Defective Antibody-Dependent Cellular Cytotoxicity and Natural Killer Cytotoxicity to Herpes Simplex Virus-Infected Cells

1984 • 48 citations

Age-dependent resistance of human alveolar macrophages to herpes simplex virus

1980 • 48 citations

Experimental Infection of Inbred Mice with Herpes Simplex Virus. III. Comparison between Newborn and Adult C57BL/6 Mice

1982 • 47 citations

Human neonatal and maternal monocyte-macrophage and lymphocyte-mediated antibody-dependent cytotoxicity to cells infected with herpes simplex

1978 • 46 citations

Macrophages and age-dependent resistance to hepatitis induced by herpes simplex virus type 2 im mice

1978 • 45 citations

Stimulation of human lymphocytes by Herpes simplex virus antigens

1975 • 44 citations

Depressed Neutrophil Motility in Patients with Recurrent Herpes Simplex Virus Infections: In Vitro Restoration with Levamisole

1977 • 42 citations

Immunity to Herpes Simplex Virus: Virus Reactivation Modulates Lymphokine Activity

1985 • 38 citations

Protection of neonatal mice against herpes simplex viral infection by human antibody and leukocytes from adult, but not neonatal humans.

1981 • 35 citations

Recognition of herpes simplex virus antigens on the surface of mouse cells of the H-2b haplotype by virus-specific cytotoxic T lymphocytes.

1984 • 35 citations

Defective in vitro lymphoproliferative responses to herpes simplex virus in patients with frequently recurring herpes infections during the disease-free interval

1978 • 34 citations

Clonal analysis of T-cell responses to herpes simplex virus: isolation, characterization and antiviral properties of an antigen-specific helper T-cell clone.

1984 • 31 citations

Resistance of C58 mice to primary systemic herpes simplex virus infection: macrophage dependence and T-cell independence

1979 • 30 citations

Effect of silica on the pathogenic distinction between herpes simplex virus type 1 and 2 hepatitis in mice

1977 • 28 citations

Macrophage Dependence of Polyriboinosinic Acid-Polyribocytidylic Acid-Induced Resistance to Herpes Simplex Virus Infection in Mice

1980 • 28 citations

Herpes Simplex Virus Type-1 and Human Lymphocytes: Virus Expression and the Response to Infection of Adult and Foetal Cells

1978 • 26 citations

Human Neonatal Leukocyte Interferon Production and Natural Killer Cytotoxicity in Response to Herpes Simplex Virus

1983 • 25 citations

Demonstration of a Receptor for IgG in Syrian Hamster Cells transformed with Herpes Simplex Virus

1974 • 24 citations

Depressed herpes simplex virus-induced lymphocyte blastogenesis in individuals with severe recurrent herpes infections

1978 • 24 citations

Specifically Immune Mause T-Cells Can Destroy H-2 Compatible Marine Target Cells Infected with Herpes Simplex Virus Types 1 or 2

1977 • 23 citations

Viral Inhibition of Lymphocyte Proliferative Responsiveness in Patients Suffering from Recurrent Lesions Caused by Herpes Simplex Virus

1985 • 23 citations

Growth of Type 2 Herpes Simplex Virus in Newborn and Adult Mononuclear Leukocytes

1979 • 23 citations

Inhibition of Mitogen- and Antigen-Induced Lymphocyte Blastogenesis by Herpes Simplex Virus

1978 • 20 citations

Cell-Mediated Cytotoxicity in Recurrent Herpes Simplex Virus Infections in Man

1977 • 19 citations

Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMRI and C57/BL mice.

1978 • 18 citations

Lymphocyte-derived chemotactic factor synthesis in initial genital herpesvirus infection: correlation with lymphocyte transformation

1980 • 14 citations

Antibody-mediated bacterial adhesion to cytomegalovirus-induced Fc receptors. Potential relationship to secondary infections complicating herpesvirus infections.

1984 • 13 citations

Neutrophils are mediators of antiviral immunity

1978 • 12 citations

Virus-infected colostral cell cytokine stimulation of human leukocyte natural killer cytotoxicity

1982 • 9 citations

Lysis of herpes simplex virus-infected cells early in the infectious cycle by human antiviral antibody and complement

1981 • 8 citations

Ontogeny of Protection of Neonatal Mice from Lethal Herpes Simplex Virus Infection by Human Leukocytes, Antiviral Antibody, and Recombinant α-Interferon

1984 • 6 citations