Evolution of a new enzymatic function by recombination within a gene.

Recalibrated linkage map of Escherichia coli K-12

1976 • 1,059 citations

REGULATION OF NEWLY EVOLVED ENZYMES. I. SELECTION OF A NOVEL LACTASE REGULATED BY LACTOSE IN ESCHERICHIA COLI

1974 • 67 citations

Experimental evolution of a new enzymatic function. Kinetic analysis of the ancestral (ebgo) and evolved (ebg+) enzymes

1976 • 53 citations

REGULATION OF NEWLY EVOLVED ENZYMES II. THE EBG REPRESSOR

1975 • 51 citations

REGULATION OF NEWLY EVOLVED ENZYMES. III EVOLUTION OF THE ebg REPRESSOR DURING SELECTION FOR ENHANCED LACTASE ACTIVITY

1977 • 45 citations

EXPERIMENTAL EVOLUTION OF A NEW ENZYMATIC FUNCTION. II. EVOLUTION OF MULTIPLE FUNCTIONS FOR EBG ENZYME IN E. COLI

1978 • 44 citations

Second naturally occurring β-galactosidase in E. coli

1974 • 36 citations

Number of mutations required to evolve a new lactase function in Escherichia coli

1977 • 30 citations