Sex-specific action of insulin to acutely increase the metabolic clearance rate of dehydroepiandrosterone in humans.

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease

1991 • 4,548 citations

Banting lecture 1988. Role of insulin resistance in human disease

1988 • 3,751 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

A Prospective Study of Dehydroepiandrosterone Sulfate, Mortality, and Cardiovascular Disease

1986 • 683 citations

Relationship of Androgenic Activity to Body Fat Topography, Fat Cell Morphology, and Metabolic Aberrations in Premenopausal Women*

1983 • 589 citations

Dehydroepiandrosterone Reduces Serum Low Density Lipoprotein Levels and Body Fat but Does not Alter Insulin Sensitivity in Normal Men*

1988 • 420 citations

Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans.

1993 • 324 citations

The Effects of Oral Dehydroepiandrosterone on Endocrine-Metabolic Parameters in Postmenopausal Women*

1990 • 315 citations

Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetic Mice

1982 • 291 citations

Lower Endogenous Androgen Levels and Dyslipidemia in Men with Non-Insulin-Dependent Diabetes Mellitus

1992 • 279 citations

DEHYDROEPIANDROSTERONE AND ANDROSTERONE LEVELS IN HUMAN PLASMA. EFFECT OF AGE AND SEX; DAY-TO-DAY AND DIURNAL VARIATIONS*

1957 • 261 citations

Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury.

1988 • 241 citations

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men.

1993 • 229 citations

THE SECRETION OF DEHYDROEPIANDROSTERONE AND DEHYDROEPIANDROSTERONE SULPHATE IN MAN

1973 • 213 citations

Sex Differences in the Twenty-Four-Hour Mean Plasma Concentrations of Dehydroisoandrosterone (DHA) and Dehydroisoandrosterone Sulfate (DHAS) and the DHA to DHAS Ratio in Normal Adults*

1980 • 189 citations

Effect of Genetic Background on the Therapeutic Effects of Dehydroepiandrosterone (DHEA) in Diabetes-Obesity Mutants and in Aged Normal Mice

1984 • 169 citations

The Effects of Hyperinsulinemia on Serum Testosterone, Progesterone, Dehydroepiandrosterone Sulfate, and Cortisol Levels in Normal Women and in a Woman with Hyperandrogenism, Insulin Resistance, and Acanthosis Nigricans*

1987 • 167 citations

Androgen Maintenance of Erectile Function in the Rat Penis1

1992 • 155 citations

Plasma dehydroepiandrosterone and dehydroepiandrosterone sulfate in patients undergoing diagnostic coronary angiography

1990 • 146 citations

Insulin-mediated vasodilation: impairment with increased blood pressure and body mass

1993 • 144 citations

Dehydroepiandrosterone feeding prevents aortic fatty streak formation and cholesterol accumulation in cholesterol-fed rabbit.

1989 • 137 citations

Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation.

1993 • 129 citations

DIVERGENT CORRELATIONS OF CIRCULATING DEHYDROEPIANDROSTERONE SULFATE AND TESTOSTERONE WITH INSULIN LEVELS AND INSULIN RECEPTOR BINDING.

1988 • 120 citations

Evidence for an association between dehydroepiandrosterone sulfate and nonfatal, premature myocardial infarction in males.

1994 • 119 citations

Adrenal Androgens in Clinical Medicine

1989 • 119 citations

Insulin reduces contraction and intracellular calcium concentration in vascular smooth muscle.

1993 • 115 citations

Suppression of Serum Dehydroepiandrosterone Sulfate Levels by Insulin: An Evaluation of Possible Mechanisms *

1989 • 114 citations

Dehydroepiandrosterone: the “missing link” between hyperinsulinemia and atherosclerosis?

1992 • 108 citations

Dehydroepiandrosterone sulphate and dehydroepiandrosterone in serum: differences related to age and sex

1988 • 95 citations

Insulin inhibits adrenal 17,20-lyase activity in man.

1992 • 92 citations

Opposing Actions of Dehydroepiandrosterone and Testosterone on Insulin Sensitivity: In Vivo and In Vitro Studies of Hyperandrogenic Females

1991 • 90 citations

Relationship of sex hormones to lipids and lipoproteins in nondiabetic men

1993 • 86 citations

Testosterone increases thromboxane A2 receptors in cultured rat aortic smooth muscle cells.

1991 • 85 citations

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate: Their Relation to Cardiovascular Disease

1991 • 81 citations

Decreased plasma dehydroepiandrosterone sulfate and dihydrotestosterone concentrations in young men after myocardial infarction

1989 • 80 citations

Effect of Acute Physiological Elevations of Insulin on Circulating Androgen Levels in Nonobese Women*

1991 • 75 citations

Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men.

1994 • 70 citations

Plasma dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins.

1993 • 58 citations

Disparate effects of insulin on isolated rabbit afferent and efferent arterioles.

1993 • 57 citations

Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice

1984 • 56 citations

Effects of Hyperinsulinemia on Muscle Fiber Composition and Capillarization in Rats

1993 • 55 citations

Maintenance of Normal Circulating Levels of Δ⁴-Androstenedione and Dehydroepiandrosterone in Simple Obesity Despite Increased Metabolic Clearance Rates: Evidence for a Servo-Control Mechanism*

1987 • 54 citations

Sex Difference in the Metabolism of Dehydroisoandrosterone Sulfate*

1980 • 53 citations

Amelioration of Insulin Resistance in Diabetes With Dehydroepiandrosterone

1993 • 52 citations

A comparison of androgen production and clearance in hirsute and obese women

1983 • 51 citations

Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Dynamics in Obesity

1975 • 49 citations

Influence of a Low-Calorie Diet and Fasting on the Metabolism of Dehydroepiandrosterone Sulfate in Adult Obese Subjects¹

1968 • 49 citations

A POSSIBLE INTERRELATION BETWEEN GLUCOSE-6-PHOSPHATE DEHYDROGENASE AND DEHYDROEPIANDROSTERONE IN OBESITY

1967 • 43 citations

The cincinnati myocardial infarction and hormone family study: Family resemblance for dehydroepiandrosterone sulfate in control and myocardial infarction families

1993 • 42 citations

Metabolism and actions of dehydroepiandrosterone in humans

1991 • 42 citations

Insulin inhibits adrenal 17,20-lyase activity in man

1992 • 41 citations

Dehydroepiandrosterone. Metabolic effects.

1976 • 40 citations

Estradiol potentiates the vasopressor response of the isolated perfused rat lung to the thromboxane mimic U-46619.

1992 • 37 citations

Bimodal Correlation between the Circulating Insulin Level and the Production Rate of Dehydroepiandrosterone: Positive Correlation in Controls and Negative Correlation in the Polycystic Ovary Syndrome with Acanthosis Nigricans*

1990 • 37 citations

Insulin infusion acutely augments ovarian androgen production in normal women

1990 • 36 citations

Role of Adrenal Androgens in the Development of Arteriosclerosis as Judged by Pulse Wave Velocity and Calcification of the Aorta

1992 • 36 citations

URINARY STEROID-EXCRETION PATTERNS AFTER ACUTE MYOCARDIAL INFARCTION

1970 • 33 citations

Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men

1994 • 31 citations

The Use of Constant Infusion of Unlabeled Dehydroepiandrosterone for the Assessmentof Its Metabolic Clearance Rate, Its Half-Life, and Its Conversion into Estrogens*

1980 • 30 citations

Further evidence of altered adrenocortical function in hypertension. Dehydroepiandrosterone excretion rate

1968 • 30 citations

Inhibitory action of dehydroepiandrosterone (DHEA) on fibroblast growth

1977 • 25 citations

Disparate effects of insulin reduction with diltiazem on serum dehydroepiandrosterone sulfate levels in obese hypertensive men and women

1994 • 23 citations

Antihyperglycemic Effect of Dehydroepiandrosterone Analogue 16α-Fluoro-5-androsten-17-one in Diabetic Mice

1993 • 21 citations

Effects of hyperinsulinemia on muscle fiber composition and capitalization in rats

1993 • 19 citations

Plasma dehydroepiandrosterone sulfate serves as a prehormone for 48% of follicular fluid testosterone during treatment with menotropins

1993 • 18 citations

Opposing actions of dehydroepiandrosterone and testosterone on insulin sensitivity. In vivo and in vitro studies of hyperandrogenic females

1991 • 17 citations

Antihyperglycemic effect of dehydroepiandrosterone analogue 16 alpha-fluoro-5-androsten-17-one in diabetic mice

1993 • 16 citations

Sexual dimorphism of vascular smooth muscle responsiveness is dependent on anions and estrogen

1991 • 14 citations

Dehydroepiandrosterone in vivoand in vitroinhibits platelet aggregation

1991 • 13 citations

Correlations of basal oestrogens with adrenal androgens and relative weight in normal women

1984 • 11 citations

A COMPARISON OF ANDROGEN PRODUCTION AND CLEARANCE IN HIRSUTE AND OBESE WOMEN

1983 • 2 citations