The neutral theory is dead. The current significance and standing of neutral and nearly neutral theories

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

1980 • 28,067 citations

The Origins of Order

1993 • 5,064 citations

Evolutionary Rate at the Molecular Level

1968 • 3,608 citations

Adaptive protein evolution at the Adh locus in Drosophila

1991 • 3,323 citations

The origins of order

1993 • 2,842 citations

Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection

1988 • 1,968 citations

Non-Darwinian Evolution

1969 • 1,731 citations

Codon usage and tRNA content in unicellular and multicellular organisms.

1985 • 1,724 citations

The causes of molecular evolution

1992 • 1,307 citations

Slightly Deleterious Mutant Substitutions in Evolution

1973 • 1,108 citations

The Nearly Neutral Theory of Molecular Evolution

1992 • 1,052 citations

The selection-mutation-drift theory of synonymous codon usage.

1991 • 994 citations

Accelerated evolution and Muller's rachet in endosymbiotic bacteria.

1996 • 983 citations

The Mosaic Genome of Warm-Blooded Vertebrates

1985 • 887 citations

Codon catalog usage and the genome hypothesis

1980 • 772 citations

Mutation rates differ among regions of the mammalian genome

1989 • 593 citations

Inferring weak selection from patterns of polymorphism and divergence at "silent" sites in Drosophila DNA.

1995 • 554 citations

ON THE GENETIC BASIS OF VARIATION AND HETEROGENEITY OF DNA BASE COMPOSITION

1962 • 515 citations

Natural Selection and the Origin of jingwei , a Chimeric Processed Functional Gene in Drosophila

1993 • 385 citations

THE ISOCHORE ORGANIZATION OF THE HUMAN GENOME

1989 • 369 citations

Synonymous and nonsynonymous substitutions in mammalian genes and the nearly neutral theory

1995 • 303 citations

Models of nearly neutral mutations with particular implications for nonrandom usage of synonymous codons

1987 • 271 citations

Recombination and mammalian genome evolution

1993 • 230 citations

Unraveling selection in the mitochondrial genome of Drosophila.

1994 • 221 citations

New methods for estimating the numbers of synonymous and nonsynonymous substitutions

1995 • 220 citations

Population genetics and phylogenetics of DNA sequence variation at multiple loci within the Drosophila melanogaster species complex.

1993 • 208 citations

Evolution of chromosome bands: Molecular ecology of noncoding DNA

1989 • 178 citations

The molecular evolution of the small heat-shock proteins in plants.

1995 • 165 citations

Multigene families and the evolution of complexity

1991 • 151 citations

Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice.

1994 • 146 citations

DNA sequence variation at the period locus within and among species of the Drosophila melanogaster complex.

1993 • 137 citations

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons.

1981 • 136 citations

On the evolution of the base composition of DNA

1962 • 132 citations

Duplication of the gamma-globin gene mediated by L1 long interspersed repetitive elements in an early ancestor of simian primates.

1991 • 123 citations

Evidence for adaptive evolution of the G6pd gene in the Drosophila melanogaster and Drosophila simulans lineages.

1993 • 108 citations

Further examples of evolution by gene duplication revealed through DNA sequence comparisons.

1994 • 107 citations

Concerted evolution of ruminant stomach lysozymes. Characterization of lysozyme cDNA clones from sheep and deer.

1990 • 96 citations

Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci

1995 • 55 citations

Why the rate of silent codon substitutions is variable within a vertebrate's genome

1988 • 48 citations

On hypervariability at the reactive center of proteolytic enzymes and their inhibitors

1994 • 27 citations