Quantitative structure-activity relationships of chymotrypsin-ligand interactions: An analysis of interactions in ϱ3 space

Partition coefficients and their uses

1971 • 4,444 citations

Aromatic substituent constants for structure-activity correlations

1973 • 1,189 citations

Steric effects in organic chemistry

1957 • 1,102 citations

The structure and action of proteins

1969 • 741 citations

A Method of Synthesis of Long Peptide Chains Using a Synthesis of Oxytocin as an Example

1959 • 509 citations

Mechanism of Action of Proteolytic Enzymes

1965 • 473 citations

The Spectrophotometric Determination of the Operational Normality of an α-Chymotrypsin Solution

1961 • 407 citations

Biological Activity and Chemical Structure

1963 • 167 citations

The Serological Properties of Simple Substances. IX. Hapten Inhibition of Precipitation of Antisera Homologous to the o-, m-, and p-Azophenylarsonic Acid Groups

1945 • 119 citations

α-Chymotrypsin: A Case Study of Substituent Constants and Regression Analysis in Enzymic Structure—Activity Relationships

1970 • 110 citations

Steric Course and Specificity of α-Chymotrypsin-catalyzed Reactions. I

1962 • 93 citations

Correlation analysis. Its application to the structure-activity relation of triazines inhibiting dihydrofolate reductase

1975 • 71 citations

Tertiary structure in carboxypeptidase

1972 • 65 citations

Studies of the Chymotrypsinogen Family. V. The Effect of Small-Molecule Contaminants on the Kinetic Behavior of α-Chymotrypsin¹

1966 • 62 citations

The influence of the geometric properties of the active centre on the specificity of α‐chymotrypsin catalysis

1972 • 55 citations

Quantitative structure-activity relationship of chymotrypsin-ligand interactions

1977 • 41 citations

Specificity of α-chymotrypsin. Separation of polar, steric, and specific effects in the α-chymotrypsin-catalyzed hydrolysis of acyl-substituted p-nitrophenyl esters

1973 • 35 citations

Quantitative structure-activity relations of D- and L-N-acyl-.alpha.-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers

1976 • 21 citations

Substituent Effects on the Chymotrypsin-Catalyzed Hydrolysis of Specific Ester Substrates

1971 • 20 citations

Inductive effect of cyclopropane

1973 • 18 citations

The Primary Specificity of Chymotrypsin. Further Evidence for “Wrong-Way” Binding^*

1966 • 16 citations

Specificity of α-chymotrypsin. α-Chymotrypsin-catalyzed hydrolysis of N-acylamino acid p-nitrophenyl esters

1973 • 13 citations

Quantitative structure-activity relations of chymotrypsin. The predictive value of correlation equations

1977 • 7 citations

Influence des effets inductifs et stériques sur la basicité des amines tertiaires

1967 • 5 citations