Flavonoids: biochemical effects and therapeutic applications

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Flavonoids, a class of natural products of high pharmacological potency

1983 • 1,647 citations

The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition

2015 • 1,500 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor

1982 • 675 citations

Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease

1984 • 628 citations

Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages

1990 • 624 citations

Phytoestrogen Interaction with Estrogen Receptors in Human Breast Cancer Cells*

1978 • 605 citations

THE BIOLOGICAL SIGNIFICANCE OF HYALURONIC ACID AND HYALURONIDASE

1947 • 529 citations

Protein kinase C inhibition by plant flavonoids

1989 • 453 citations

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

1988 • 443 citations

Ascorbic acid and cancer: a review.

1979 • 425 citations

Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor.

1983 • 395 citations

Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation

1990 • 332 citations

Selectivity of Neutrophil 5-Lipoxygenase and Cyclo-oxygenase Inhibition by an Anti-inflammatory Flavonoid Glycoside and Related Aglycone Flavonoids

1988 • 321 citations

Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids

1991 • 314 citations

Inhibition of Human Estrogen Synthetase (Aromatase) by Flavones

1984 • 310 citations

Vitamin P: Flavonols as Vitamins

1936 • 301 citations

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.

1981 • 290 citations

Antimutagens and anticarcinogens: A survey of putative interceptor molecules

1990 • 268 citations

Induction of mammalian topoisomerase ii dependent dna cleavage by nonintercalative flavonoids, genistein and orobol

1990 • 219 citations

Bioflavonoid interaction with rat uterine type ii binding sites and cell growth inhibition

1988 • 208 citations

Heterogeneity of estrogen binding sites in the cytosol of the rat uterus

1978 • 199 citations

Plant flavonoids in biology and medicine

1985 • 194 citations

Inhibition of in vitro microsomal lipid peroxidation by isoflavonoids

1985 • 141 citations

Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice.

1986 • 135 citations

Inhibitory effect of quercetin on OVCA 433 cells and presence of type II oestrogen binding sites in primary ovarian tumours and cultured cells

1990 • 130 citations

Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase

1978 • 128 citations

Antithyroid and Goitrogenic Effects of Millet: Role of C-Glycosylflavones*

1989 • 124 citations

Structure-activity studies of flavonoids as inhibitors of hyaluronidase

1990 • 123 citations

Inhibition of tyrosine protein kinase activity by synthetic isoflavones and flavones.

1989 • 121 citations

Structure/activity studies of flavonoids as inhibitors of cyclic AMP phosphodiesterase and relationship to quantum chemical indices.

1979 • 109 citations

Effects of ipriflavone and its metabolites on a clonal osteoblastic cell line

1991 • 108 citations

Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (±)-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse

1985 • 107 citations

Inhibition of reverse transcriptases by flavonoids

1989 • 106 citations

Modification of arachidonic metabolism by flavonoids

1987 • 103 citations

THE FLAVONOIDS; A CLASS OF SEMI-ESSENTIAL FOOD COMPONENTS: THEIR ROLE IN HUMAN NUTRITION

1976 • 102 citations

Bradyrhizobium japonicum nodD1 can be specifically induced by soybean flavonoids that do not induce the nodYABCSUIJ operon.

1992 • 99 citations

Effect of ipriflavone on glucocorticoid-induced osteoporosis in rats

1986 • 90 citations

The effect of ipriflavone (TC-80) on bone resorption in tissue culture

1986 • 86 citations

Type II oestrogen binding sites in acute lymphoid and myeloid leukaemias: growth inhibitory effect of oestrogen and flavonoids

1990 • 85 citations

Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site.

1986 • 77 citations

Metabolism of the Thyroid Hormones

1987 • 69 citations

Type‐II estrogen binding sites in a lymphoblastoid cell line and growth‐inhibitory effect of estrogen, anti‐estrogen and bioflavonoids

1990 • 66 citations

Inhibition of Hyaluronidase

1955 • 63 citations

Effect of two flavonoid compounds on central nervous system. Analgesic activity

1991 • 62 citations

Genetic toxicology of the diet

1986 • 61 citations

Flavonoids, but not protein kinase c inhibitors, prevent stress protein synthesis during erythrophagocytosis

1991 • 60 citations

Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids

1991 • 60 citations

Preliminary characterization of an endogenous inhibitor of [3H]estradiol binding in rat uterine nuclei.

1983 • 59 citations

Effect of Ipriflavone on Osteoporosis Induced by Ovariectomy in Rats

1985 • 57 citations

Ipriflavone inhibits osteoclast differentiation in parathyroid transplanted parietal bone of rats

1992 • 57 citations

Effect of catechins and citrus flavonoids on invasionin vitro

1991 • 56 citations

Rapid Effects of the Flavonoid EMD 21388 on Serum Thyroid Hormone Binding and Thyrotropin Regulation in the Rat*

1989 • 55 citations

Type II Estrogen Receptors in the Papillary Cystic Tumor of the Pancreas

1989 • 55 citations

Inhibitory Effects of Hydrangenol Derivatives on the Activation of Hyaluronidase and their Antiallergic Activities

1988 • 53 citations

Identification, purification, and characterization of S-adenosyl-l-methionine: Isoliquiritigenin 2′-O-methyltransferase from alfalfa (Medicago sativa L.)

1992 • 49 citations

Methyl p-hydroxyphenyllactate and nuclear type II binding sites in malignant cells: metabolic fate and mammary tumor growth.

1990 • 48 citations

An endogenous inhibitor of [3H]estradiol binding to nuclear type II estrogen binding sites in normal and malignant tissues.

1984 • 47 citations

Effect of myricetin and other flavonoids on the liver plasma membrane Ca2+ pump kinetics and structure-function relationships

1991 • 36 citations

Comparison of the effects of various flavonoids on ethoxycoumarin deethylase activity of rat intestinal and hepatic microsomes

1986 • 35 citations

Genetic toxicology of dietary flavonoids.

1986 • 31 citations

BE-14348 substances, new specific estrogen-receptor binding inhibitors. Production, isolation, structure determination and biological properties.

1990 • 28 citations

Effects of Ipriflavone on Bone and Mineral Metabolism in the Streptozotocin Diabetic Rat

1985 • 27 citations

Effect of Parathyroid Hormone on Parietal Bones of Rats, and Effect of Ipriflavone

1987 • 24 citations

Inhibition of Rat Heart Phosphodiesterase by some Rotenoids and Isoflavonoids

1983 • 20 citations

Flavonoid Modulation of Murine Neutrophil Cytokinesis

1990 • 18 citations

Disposition of ipriflavone (TC-80) in rats and dogs.

1985 • 17 citations

Iodothyronine deiodinase is inhibited by plant flavonoids.

1986 • 16 citations

Modulation of Rat Hepatic Aryl Hydrocarbon Hydroxylase by Various Flavones and Polycyclic Aromatic Hydrocarbons

1985 • 14 citations