Renal fibrosis: Insights into pathogenesis and treatment

Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.

1995 • 1,167 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

RELATIONSHIP BETWEEN RENAL FUNCTION AND HISTOLOGICAL CHANGES FOUND IN RENAL-BIOPSY SPECIMENS FROM PATIENTS WITH PERSISTENT GLOMERULAR NEPHRITIS

1968 • 652 citations

Fibrogenic cytokines: the role of immune mediators in the development of scar tissue

1991 • 607 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation.

1991 • 461 citations

CULTIVATING LEUKÆMIC LYMPHOCYTES

1968 • 424 citations

Expression of transforming growth factor-β isoforms in human glomerular diseases

1996 • 424 citations

Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model

1992 • 404 citations

Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

1995 • 364 citations

Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor.

1992 • 345 citations

Mechanisms of tubulointerstitial fibrosis

1991 • 291 citations

Enhanced expression of “muscle-specific” actin in glomerulonephritis

1992 • 268 citations

Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.

1993 • 254 citations

Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens.

1989 • 240 citations

Leukocyte adhesion molecules and kidney diseases

1994 • 235 citations

The glomerular response to injury: Progression or resolution?

1994 • 230 citations

Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis

1994 • 228 citations

Growth factors in glomerulonephritis

1993 • 178 citations

Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1.

1989 • 167 citations

Interstitial fibrosis in obstructive nephropathy

1993 • 166 citations

Modulation of neutrophil influx in glomerulonephritis in the rat with anti-macrophage inflammatory protein-2 (MIP-2) antibody.

1995 • 163 citations

The pathobiology of the mesangium

1992 • 162 citations

Incidence of advanced chronic renal failure and the need for end stage renal replacement treatment.

1990 • 141 citations

Myofibroblasts, predictors of progression of mesangial IgA nephropathy?

1994 • 139 citations

Cytokines in Kidney Disease: The Role of Transforming Growth Factor-β

1993 • 131 citations

Macrophages in renal injury.

1994 • 115 citations

Myofibroblasts and the progression of experimental glomerulonephritis.

1995 • 114 citations

Distribution of interleukin-6 in normal and diseased human kidney.

1991 • 110 citations

Contribution of mononuclear leucocytes to the progression of experimental focal glomerular sclerosis

1990 • 99 citations

Dietary protein restriction rapidly reduces transforming growth factor beta 1 expression in experimental glomerulonephritis.

1991 • 96 citations

Tubular-Derived Growth Factors and Cytokines in the Pathogenesis of Tubulointerstitial Fibrosis: Implications for Human Renal Disease Progression

1994 • 89 citations

Tubular and interstitial factors in the progression of glomerulonephritis

1992 • 84 citations

Pathogenesis of lung fibrosis and potential new therapeutic strategies.

1995 • 80 citations

Tubular gelatinase A (MMP-2) and its tissue inhibitors in polycystic kidney disease in the Han:SPRD rat

1996 • 78 citations

Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts

1995 • 72 citations

Fibroblasts of rabbit kidney in culture. II. Paracrine stimulation of papillary fibroblasts by PDGF

1991 • 70 citations

The biology of the glomerulus: Endothelial cells

1994 • 64 citations

Adhesion molecule interactions in human glomerulonephritis: Importance of the tubulointerstitium

1996 • 63 citations

Chemokines and renal disease

1995 • 62 citations

Transfer of a mutated gene encoding active transforming growth factor-β1 suppresses mitogenesis and IL-1 response in the glomerulus

1995 • 60 citations

Mesangial cell behavior in a three-dimensional extracellular matrix

1991 • 59 citations

Immune Mechanisms in Idiopathic Membranous Nephropathy: The Role of the Interstitial Infiltrates

1989 • 58 citations

Molecular nephrology : kidney function in health and disease

1995 • 57 citations

Interstitial macrophages as mediators of renal fibrosis.

1995 • 57 citations

Experimental diffuse interstitial renal fibrosis. A biochemical approach.

1988 • 56 citations

Differential expression of macrophage inflammatory protein-2 and monocyte chemoattractant protein-1 in experimental glomerulonephritis

1996 • 49 citations

Platelets in inflammatory glomerular injury.

1991 • 41 citations

Pexicrine effects of basement membrane components on paracrine signaling by renal tubular cells

1996 • 41 citations

Anti-inflammatory lymphokine mRNA expression in antibody-induced glomerulonephritis

1996 • 39 citations

Modulation of antibody-mediated glomerular injury in vivo by interleukin-6

1993 • 34 citations

Intraglomerular Proteinase Activity in Adriamycin-lnduced Nephropathy

1992 • 22 citations

Tissue inhibitor of the metalloproteinases and renal extracellular matrix accumulation.

1995 • 14 citations

Pathogenesis, experimental manipulation and treatment of liver fibrosis.

1995 • 9 citations

Interstitial macrophages.

1993 • 8 citations

The management of chronic renal failure: ten unanswered questions.

1991 • 5 citations

II. Prevalence of ESRD therapy

1995 • 4 citations

The Management of Chronic Renal Failure: Ten Unanswered Questions

1991 • 4 citations

Innovative strategies for pharmacological intervention in immune damage to the kidney

1995 • 2 citations