Orphan G protein-coupled receptors in the CNS

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Characterization of the human cysteinyl leukotriene CysLT1 receptor

1999 • 960 citations

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

1999 • 783 citations

Characterization of Apelin, the Ligand for the APJ Receptor

2000 • 650 citations

Characterization of the Human Cysteinyl Leukotriene 2 Receptor

2000 • 649 citations

New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals

2000 • 557 citations

Molecular and Functional Characteristics of APJ

2000 • 464 citations

The hypocretin/orexin ligand–receptor system: implications for sleep and sleep disorders

2000 • 451 citations

Pharmacology of nociceptin and its receptor: a novel therapeutic target

2000 • 426 citations

Receptor for Motilin Identified in the Human Gastrointestinal System

1999 • 396 citations

Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor

2000 • 376 citations

Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum

1999 • 341 citations

A G Protein-coupled Receptor for UDP-glucose

2000 • 338 citations

Cutting Edge: The Orphan Chemokine Receptor G Protein-Coupled Receptor-2 (GPR-2, CCR10) Binds the Skin-Associated Chemokine CCL27 (CTACK/ALP/ILC)

2000 • 327 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2)

2000 • 285 citations

Isolation and cDNA Cloning of a Novel Galanin-like Peptide (GALP) from Porcine Hypothalamus

1999 • 273 citations

Receptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor

2000 • 248 citations

Identification of Urotensin II as the Endogenous Ligand for the Orphan G-Protein-Coupled Receptor GPR14

1999 • 240 citations

Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction

1999 • 236 citations

Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus

1998 • 217 citations

Alternative role for prolactin-releasing peptide in the regulation of food intake

2000 • 215 citations

Urotensin II Is the Endogenous Ligand of a G-Protein-Coupled Orphan Receptor, SENR (GPR14)

1999 • 208 citations

Identification of Neuromedin U as the Cognate Ligand of the Orphan G Protein-coupled Receptor FM-3

2000 • 203 citations

Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System

2000 • 197 citations

Neuromedin U Is a Potent Agonist at the Orphan G Protein-coupled Receptor FM3

2000 • 174 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone

1999 • 155 citations

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology

1999 • 134 citations

Stimulation of corticotropin-releasing hormone-mediated adrenocorticotropin secretion by central administration of prolactin-releasing peptide in rats

2000 • 130 citations

Identification of a Human Gastrointestinal Tract and Immune System Receptor for the Peptide Neuromedin U

2000 • 129 citations

Stimulation of Prolactin Release by Prolactin-Releasing Peptide in Rats

1999 • 112 citations

Two related G protein-coupled receptors: The distribution of GPR7 in rat brain and the absence of GPR8 in rodents

1999 • 105 citations

Central administration of prolactin-releasing peptide stimulates oxytocin release in rats

1999 • 101 citations

High sensitivity detection of JC-virus DNA in postmortem brain tissue byin situPCR

2000 • 96 citations

CCR11 Is a Functional Receptor for the Monocyte Chemoattractant Protein Family of Chemokines

2000 • 91 citations

Melanin-concentrating Hormone Receptor: An Orphan Receptor Fits the Key

2000 • 87 citations

A Novel G-Protein-Coupled Receptor Gene Expressed in Striatum

2000 • 86 citations

Cutting Edge: Identification of the Orphan Receptor G-Protein-Coupled Receptor 2 as CCR10, a Specific Receptor for the Chemokine ESkine

2000 • 82 citations

Prolactin Releasing Peptide (PrRP) Stimulates Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) via a Hypothalamic Mechanism in Male Rats

2000 • 82 citations

Prolactin-Releasing Peptides Do Not Stimulate Prolactin Release in vivo

2000 • 81 citations

The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors

2000 • 81 citations

Prolactin‐Releasing Peptide is Expressed in Afferents to the Endocrine Hypothalamus, but not in Neurosecretory Neurones

2000 • 77 citations

Life on the edg

1999 • 72 citations

Cellular localization of prolactin-releasing peptide messenger RNA in the rat brain

1999 • 58 citations

The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors

1999 • 56 citations

Molecular cloning of a novel putative G protein‐coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system

1993 • 56 citations

Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6

2000 • 45 citations

Cloning, sequencing and tissue distribution of a candidate G protein‐coupled receptor from rat pituitary gland

1991 • 30 citations

Prolactin Releasing Peptide (PrRP) Stimulates Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) via a Hypothalamic Mechanism in Male Rats

2000 • 29 citations