New immunosuppressive drugs: Needs in and applications to pediatric transplantation

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Cyclosporine

1989 • 1,340 citations

FK 506 FOR LIVER, KIDNEY, AND PANCREAS TRANSPLANTATION

1989 • 1,043 citations

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 • 641 citations

INDIVIDUALIZATION OF CYCLOSPORINE THERAPY USING PHARMACOKINETIC AND PHARMACODYNAMIC PARAMETERS

1985 • 278 citations

Randomized Controlled Trial of a Monoclonal Antibody against the Interleukin-2 Receptor (33B3.1) as Compared with Rabbit Antithymocyte Globulin for Prophylaxis against Rejection of Renal Allografts

1990 • 274 citations

RS-61443—A NEW, POTENT IMMUNOSUPPRESSIVE AGENT

1991 • 239 citations

Kidney Transplantation Under FK 506

1990 • 236 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

Rusting of the Lock and Key Model for Protein-Ligand Binding

1991 • 223 citations

SYNERGISTIC INTERACTIONS OF CYCLOSPORINE AND RAPAMYCIN TO INHIBIT IMMUNE PERFORMANCES OF NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES IN VITRO

1991 • 205 citations

FK 506 for human liver, kidney, and pancreas transplantation

1989 • 168 citations

Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.

1991 • 154 citations

PRECLINICAL EVALUATION OF A NEW POTENT IMMUNOSUPPRESSIVE AGENT, RAPAMYCIN

1991 • 147 citations

SPARING OF SUPPRESSOR CELLS

1984 • 118 citations

Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor.

1991 • 109 citations

Receptor-Induced Conformation Change of the Immunosuppressant Cyclosporin A

1991 • 91 citations

SUPPRESSOR T CELLS IN RATS WITH PROLONGED CARDIAC ALLOGRAFT SURVIVAL AFTER TREATMENT WITH CYCLOSPORINE1

1984 • 80 citations

THE EFFECT OF A NEW IMMUNOSUPPRESSIVE DRUG, BREQUINAR SODIUM, ON HEART, LIVER, AND KIDNEY ALLOGRAFT REJECTION IN THE RAT

1992 • 76 citations

THE ADVERSE IMPACT OF CYTOMEGALOVIRUS INFECTION ON CLINICAL OUTCOME IN CYCLOSPORINE-PREDNISONE TREATED RENAL ALLOGRAFT RECIPIENTS

1988 • 62 citations

A RANDOMIZED TRIAL OF CYCLOSPORINE AND PREDNISOLONE VERSUS CYCLOSPORINE, AZATHIOPRINE, AND PREDNISOLONE IN PRIMARY CADAVERIC RENAL TRANSPLANTATION

1992 • 59 citations

A RANDOMIZED TRIAL COMPARING TRIPLE-DRUG AND DOUBLE-DRUG THERAPY IN RENAL TRANSPLANTATION

1988 • 58 citations

A RANDOMIZED TRIAL COMPARING DOUBLE-DRUG AND TRIPLE-DRUG THERAPY IN PRIMARY CADAVERIC RENAL TRANSPLANTS

1990 • 53 citations

ANALYSIS OF THE INTERACTIONS OF IMMUNOSUPPRESSIVE DRUGS WITH CYCLOSPORINE IN INHIBITING DNA PROLIFERATION

1990 • 43 citations

The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy

1989 • 29 citations

Effect of combined anti-gamma interferon antibody and cyclosporine therapy on cardiac allograft survival in the rat.

1988 • 23 citations

Prolongation of dog renal allograft survival by RS-61443, a new, potent immunosuppressive agent.

1991 • 13 citations

Mechanism of unresponsiveness in rats induced by a short course of FK 506 or CyA.

1991 • 8 citations

IN VITRO ANALYSIS OF T CELL-MEDIATED CYTOTOXICITY DISPLAYED BY RAT HEART ALLOGRAFT RECIPIENTS RENDERED UNRESPONSIVE BY TOTAL-LYMPHOID IRRADIATION AND EXTRACTED DONOR ANTIGEN

1990 • 5 citations

Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes.

1991 • 4 citations

Immunosuppressive therapy

1992 • 2 citations

Deleted Work

1955 • 0 citations