Review article : Opioid analgesics in the management of pain in patients with cancer. A review

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Human Pharmacology and Abuse Potential of the Analgesic Buprenorphine

1978 • 787 citations

Buprenorphine

1979 • 400 citations

Analgesic Effect of Morphine Glucuronides

1971 • 367 citations

Accumulation of Normeperidine, an Active Metabolite of Meperidine, in Patients with Renal Failure or Cancer

1977 • 354 citations

Symptom Control in Far Advanced Cancer: Pain Relief

1984 • 329 citations

THE ANIMAL PHARMACOLOGY OF BUPRENORPHINE, AN ORIPAVINE ANALGESIC AGENT

1977 • 319 citations

Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography

1982 • 278 citations

The Pharmacokinetics of Heroin in Patients with Chronic Pain

1984 • 242 citations

Kinetics of intravenous and intramuscular morphine

1978 • 236 citations

The Relationship of Pharmacokinetics to Pharmacological Activity

1976 • 231 citations

Morphine metabolism in man

1974 • 228 citations

The Metabolism of Morphine and Heroin in Man

1975 • 215 citations

Evidence from opiate binding studies that heroin acts through its metabolites

1983 • 207 citations

Morphine kinetics in cancer patients

1981 • 170 citations

Normal Metabolism of Morphine in a Cirrhosis

1981 • 164 citations

Patient-Controlled Analgesia

1983 • 148 citations

Analgesic effectiveness of the narcotic agonist‐antagonists.

1979 • 139 citations

Respiratory depression after intrathecal narcotics

1980 • 138 citations

Drugs Five Years Later: Naloxone

1976 • 134 citations

Morphine metabolism in cancer patients on increasing oral doses‐no evidence for autoinduction or dose‐dependence.

1983 • 132 citations

Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation.

1985 • 131 citations

Naloxone

1983 • 129 citations

Mild analgesics. A review of their clinical pharmacology.

1965 • 125 citations

A Comparative Evaluation of Marketed Analgesic Drugs

1972 • 125 citations

THE CLINICAL MEASUREMENT OF PAIN

1960 • 120 citations

Plasma codeine and morphine concentrations after therapeutic oral doses of codeine‐containing analgesics

1978 • 116 citations

Sublingual buprenorphine used postoperatively: clinical observations and preliminary pharmacokinetic analysis.

1981 • 115 citations

Unexpected complication of successful nerve block

1981 • 112 citations

Analgesic and Mood Effects of Heroin and Morphine in Cancer Patients with Postoperative Pain

1981 • 104 citations

Analgesic studies of codeine and oxycodone in patients with cancer. I. Comparisons of oral with intramuscular codeine and of oral with intramuscular oxycodone.

1978 • 103 citations

A comparison of the analgesic effect of intramuscular nalbuphine and morphine in patients with postoperative pain.

1978 • 101 citations

Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat

1978 • 98 citations

Serum morphine levels

1984 • 97 citations

Narcotic Antagonists as Analgesics

1962 • 95 citations

PHARMACOKINETICS OF SINGLE-DOSE I.V.MORPHINE IN NORMAL VOLUNTEERS AND PATIENTS WITH END-STAGE RENAL FAILURE

1984 • 94 citations

Relation between morphine pharmacokinetics and analgesia

1978 • 90 citations

Morphine binding to human plasma proteins

1975 • 87 citations

Oral analgesic studies: Pentazocine hydrochloride, codeine, aspirin, and placebo and their influence on response to placebo

1966 • 85 citations

Simple Analgesics for Arthritis

1974 • 83 citations

NALOXONE VERSUS PLACEBO IN TREATMENT OF SEPTIC SHOCK

1985 • 82 citations

INTRODUCTION

1983 • 81 citations

Spinal fluid kinetics of morphine and heroin

1984 • 80 citations

Morphine concentrations in blood and organs in cases of fatal poisoning

1974 • 76 citations

Studies of the enterohepatic circulation of morphine in the rat.

1975 • 73 citations

Actions and metabolism of heroin administered by continuous intravenous infusion to man

1971 • 71 citations

A comparison of the analgesic effects of profadol and morphine in patients with cancer

1969 • 68 citations

Analgesics: Esters of 4-Dialkylamino-1,2-diphenyl-2-butanols

1953 • 68 citations

MILD ANALGESICS A REVIEW OF THEIR CLINICAL PHARMACOLOGY (Part II)

1966 • 65 citations

Differentiation of potent μ- and κ-opiate agonists using heat and pressure antinociceptive profiles and combined potency analysis

1982 • 65 citations

Pharmacokinetics of Morphine and Its Surrogates III: Morphine and Morphine 3-Monoglucuronide Pharmacokinetics in The Dog as a Function of Dose

1979 • 62 citations

FATAL DEXTROPROPOXYPHENE POISONING IN NORTHERN IRELAND

1977 • 62 citations

Propoxyphene and norpropoxyphene kinetics after single and repeated doses of propoxyphene

1982 • 62 citations

A comparison of the analgesic effects of pentazocine and morphine in patients with cancer

1966 • 61 citations

Animal and molecular pharmacology of mixed agonist‐antagonist analgesic drugs.

1979 • 60 citations

A trial of sublingual buprenorphine in cancer pain.

1979 • 60 citations

Pharmacokinetics of Intravenous Morphine in Patients Anesthetized with Enflurane–Nitrous Oxide

1981 • 59 citations

Human pharmacology of narcotic antagonists.

1979 • 52 citations

Morphine kinetics during and after renal transplantation

1984 • 52 citations

Independent central and peripheral mediation of morphine-induced inhibition of gastrointestinal transit in rats.

1986 • 52 citations

Aspirin and Acetaminophen as Constituents of Analgesic Combinations

1981 • 51 citations

Determination of heroin and its metabolites by high-performance liquid chromatography

1982 • 51 citations

The antinociceptive activity of meptazinol depends on both opiate and cholinergic mechanisms

1983 • 49 citations

Renal failure does not impair the metabolism of morphine.

1986 • 48 citations

Plasma morphine concentrations during chronic oral administration in patients with cancer pain

1982 • 47 citations

Kinetics of high‐dose intravenous morphine in cardiac surgery patients

1976 • 45 citations

Analgesic and side effects of pentazocine and morphine in a large population of postoperative patients

1969 • 44 citations

Analgesic Efficacy of Dextropropoxyphene and Dextropropoxyphene-containing Combinations: a Review

1984 • 43 citations

Distalgesic poisoning--cause for concern.

1980 • 42 citations

CONTROLLED-RELEASE MORPHINE TABLETS

1981 • 42 citations

A clinical comparison of the effects of oral and intramuscular administration of analgesics: Pentazocine and phenazocine

1968 • 42 citations

Controlled release morphine sulphate tablets‐‐a study in normal volunteers.

1980 • 40 citations

High and low affinity opioid binding sites: Relationship to mu and delta sites

1982 • 40 citations

T's and Blues

1980 • 38 citations

Pharmacologic and Toxic Effects in Animals of Dextropropoxyphene and its Major Metabolite Norpropoxyphene: a Review

1984 • 37 citations

Medicines Evaluation and Monitoring Group: Central Nervous System Effects of Pentazocine

1974 • 36 citations

Transport and metabolism of [3H]morphine in isolated, nonperfused proximal tubular segments of the rabbit kidney.

1982 • 35 citations

Langzeittherapie von Krebsschmerzen: Kontrollierte Studie mit Buprenorphin

2008 • 35 citations

Evaluation of New Analgesics

1980 • 35 citations

Influence of First‐Pass Effect on the Systemic Availability of Propoxyphene

1972 • 33 citations

The Pharmacological Basis of Therapeutics (seventh edition)

1986 • 31 citations

Analgesic effect of intramuscular and oral nalbuphine in postoperative pain

1981 • 31 citations

Glucuronidation of Morphine in Human Liver and Interaction with Oxazepam

1982 • 31 citations

Intradural morphine and diamorphine

1984 • 30 citations

The analgesic effectiveness of codeine and meperidine (demerol).

1954 • 29 citations

Clinical Effects of Pentazocine in Hospitalized Medical Patients

1975 • 27 citations

Distalgesic and its equivalents: time for action

1983 • 27 citations

Pharmacokinetics of a Single-Dose IV Morphine in Normal Volunteers and Patients with End-Stage Renal Failure

1985 • 27 citations

Psychomimetic effects of pentazocine and dihydrocodeine tartrate.

1978 • 25 citations

The effectiveness of D-propoxyphene hydrochloride and codeine phosphate as determined by two methods of clinical testing for relief of chronic pain.

1956 • 25 citations

Dextropropoxyphene Deaths: Coroner's Report

1984 • 23 citations

Comparison of the effects of therapeutic doses of meptazinol and a dextropropoxyphene/paracetamol mixture alone and in combination with ethanol on ventilatory function and saccadic eye movements.

1985 • 23 citations

Drug Points: Buprenorphine: dangerous drug or overlooked therapy?

1986 • 22 citations

Common Misunderstandings about The Use of Morphine for Chronic Pain in Advanced Cancer

1985 • 19 citations

New portable infusion pump for prolonged subcutaneous administration of opioid analgesics in patients with advanced cancer.

1986 • 19 citations

High-dose morphine and respiratory function in chronic cancer pain

1981 • 18 citations

Addiction to Distalgesic (dextropropoxyphene).

1980 • 18 citations

THE ALIMENTARY ABSORPTION OF DIAMORPHINE AND MORPHINE IN MAN AS INDICATED BY URINARY EXCRETION STUDIES

1974 • 17 citations

Heroin vs Morphine for Cancer Pain?

1986 • 17 citations

TWO COMPARISONS OF THE ANALGESIC ACTIVITY OF ORALLY ADMINISTERED PENTAZOCINE, DIHYDROCODEINE AND PLACEBO

1971 • 16 citations

Pharmacokinetics of Dextropropoxyphene and Nordextropropoxyphene in Elderly Hospital Patients after Single and Multiple Doses of Distalgesic. Preliminary Analysis of Results

1984 • 14 citations

Controversy in the management of chronic cancer pain: Therapeutic equivalents of IM and PO morphine

1986 • 13 citations

Metabolism of Morphine in the Perfused Rat Liver

1976 • 9 citations

Morphine metabolism in patients with liver cirrhosis

1985 • 9 citations

A Double‐Blind Comparison of Meptazinol with Pentazocine and Placebo in Cancer Pain

1978 • 8 citations

The Distribution of Morphine in Man Following Chronic Intravenous Administration

1977 • 8 citations

A long-term open assessment of sublingual buprenorphine in patients suffering from chronic pain

1981 • 6 citations

[Sublingual buprenorphine in the treatment of pain caused by cancer. Transition to buprenorphine from other opiates].

1983 • 5 citations

Naloxone - opiate antagonist

1981 • 3 citations

Filling the gap between aspirin and morphine

1984 • 2 citations

Disposition and Effects of Heroin in Pain Patients

1985 • 2 citations

Pharmacological Factors in Drug Dependence

1972 • 1 citations

U.S. trials show heroin not superior to morphine

1982 • 1 citations

U.S. trials show heroin not superior to morphine.

1982 • 1 citations