Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron.

Multiple Range and Multiple F Tests

1955 • 22,685 citations

[30] Microsomal lipid peroxidation

1978 • 12,818 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.

1984 • 849 citations

Hepatic Microsomal Ethanol Oxidation

1972 • 603 citations

Phytic acid. A natural antioxidant.

1987 • 456 citations

Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

1983 • 338 citations

Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro

1979 • 280 citations

Assay Using Brain Homogenate for Measuring the Antioxidant Activity of Biological Fluids

1974 • 243 citations

The Role of Iron in Enzymatic Lipid Peroxidation

1982 • 233 citations

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

1982 • 222 citations

The Kinetics and Mechanism of Iron(III) Exchange between Chelates and Transferrin

1967 • 200 citations

The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction.

1982 • 199 citations

Intracellular hydroxyl radical production induced by recombinant human tumor necrosis factor and its implication in the killing of tumor cells in vitro.

1989 • 199 citations

Effects of non-steroidal anti-inflammatory agents on human neutrophil functions in vitro and in vivo

1984 • 182 citations

Anaphylactic release of thromboxane A2, prostaglandin D2, and prostacyclin from human lung parenchyma.

1981 • 168 citations

The iron-binding and hydroxyl radical scavenging action of anti-inflammatory drugs

1988 • 154 citations

Source of iron in neutrophil-mediated killing of endothelial cells.

1987 • 134 citations

Ibuprofen in canine endotoxin shock.

1982 • 131 citations

Effect of a specific iron chelating agent on animal models of inflammation.

1983 • 125 citations

Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin

1987 • 118 citations

Role of transferrin and ceruloplasmin in antioxidant activity of lung epithelial lining fluid

1988 • 113 citations

Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.

1983 • 99 citations

Pharmacological modification of pulmonary vascular injury: possible role of cAMP

1987 • 72 citations

Dibutyryl cAMP, aminophylline, and beta-adrenergic agonists protect against pulmonary edema caused by phosgene

1989 • 72 citations

Medical Phosgene Problems and Their Possible Solution

1978 • 58 citations

Thromboxane-induced pulmonary vasoconstriction: involvement of calcium

1985 • 58 citations

Pulmonary alterations in rats due to acute phosgene inhalation*1

1987 • 53 citations

Hydroxyl-free radicals and anti-inflammatory drugs: biological inactivation studies and reaction rate constants

1983 • 53 citations

Concentration-Time Product (CT) as an Expression of Dose in Sublethal Exposures to Phosgene

1964 • 52 citations

Amiodarone Causes Acute Oxidant Lung Injury in Ventilated and Perfused Rabbit Lungs

1988 • 51 citations

The Role of Cyclooxygenase and Lipoxygenase Mediators in Oxidant-induced Lung Injury

1988 • 49 citations

Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis

1988 • 46 citations

Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release

1986 • 40 citations

Effects of the Newer Nonsteroidal Anti-Inflammatory Agents, Ibuprofen, Fenoprofen, and Sulindac, on Neutrophil Adherence

1985 • 34 citations

Ibuprofen prevents synthetic smoke-induced pulmonary edema.

1986 • 30 citations

Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.

1984 • 23 citations

Ibuprofen prevents thrombin-induced lung vascular injury: mechanism of effect

1987 • 23 citations

Inhibition of ferrous iron induced oxidation of arachidonic acid by indomethacin

1979 • 22 citations

Mechanism of hyperoxia-induced pulmonary vascular paralysis: effect of antioxidant pretreatment

1985 • 21 citations

Selective action of prostaglandin F2α during paraquat-induced pulmonary edema in the perfused lung

1983 • 19 citations

An Improved Method for Determination of Phosgene in Air

1971 • 17 citations

Studies into the effects of the iron chelator desferrioxamine on the inflammatory process.

1984 • 13 citations

Ibuprofen and Diphenhydramine Reduce the Lung Lesion of Endotoxemia in Sheep

1984 • 11 citations

Attenuation by 2,3-dihydroxybenzoic acid of acute lung injury induced by cobra venom factor in the rat.

1985 • 8 citations

Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors.

1985 • 7 citations

Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis

1989 • 3 citations

Pulmonary Alterations in Rats Due to Acute Phosgene Inhalation

1987 • 2 citations