The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization

Migraine — Current Understanding and Treatment

2002 • 1,890 citations

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

An association between migraine and cutaneous allodynia

2000 • 953 citations

Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms

1991 • 942 citations

Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold

1987 • 905 citations

DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLIS

1986 • 787 citations

The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine

2000 • 737 citations

Subcutaneous administration of botulinum toxin A reduces formalin-induced pain

2003 • 652 citations

The origin, structure, and pharmacological activity of botulinum toxin.

1981 • 637 citations

Defeating migraine pain with triptans: A race against the development of cutaneous allodynia

2003 • 597 citations

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

1992 • 597 citations

EFNS guidelines on neuropathic pain assessment

2004 • 529 citations

Regulation of Calcitonin Gene‐Related Peptide Secretion From Trigeminal Nerve Cells by Botulinum Toxin Type A: Implications for Migraine Therapy

2004 • 528 citations

Review of a Proposed Mechanism for the Antinociceptive Action of Botulinum Toxin Type A

2005 • 517 citations

Dynamic and static components of mechanical hyperalgesia in human hairy skin

1992 • 510 citations

Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins

2000 • 474 citations

Localized injections of botulinum toxin for the treatment of focal dystonia and hemifacial spasm

1987 • 408 citations

PHENOTHIAZINE DYSKINESIA AFTER LEUCOTOMY

1964 • 397 citations

Evidence for Antinociceptive Activity of Botulinum Toxin Type A in Pain Management

2003 • 391 citations

Botulinum toxin in clinical practice

2004 • 384 citations

Cutaneous Active Vasodilation in Humans Is Mediated by Cholinergic Nerve Cotransmission

1995 • 363 citations

Deconstructing migraine headache into peripheral and central sensitization

2001 • 354 citations

Botulinum toxin in the treatment of myofascial pain syndrome

1994 • 340 citations

Comparison of lidocaine injection, botulinum toxin injection, and dry needling to trigger points in myofascial pain syndrome

2004 • 334 citations

Experimental cranial pain elicited by capsaicin: a PET study

1998 • 278 citations

A laser Doppler scanner for imaging blood flow in skin

1991 • 257 citations

Migraine: Preventive Treatment

2002 • 255 citations

Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms

2000 • 241 citations

Synaptic Transmission: Inhibition of Neurotransmitter Release by Botulinum Toxins

2003 • 233 citations

Presynaptic Effects of Botulinum Toxin Type A on the Neuronally Evoked Response of Albino and Pigmented Rabbit Iris Sphincter and Dilator Muscles

2000 • 214 citations

Regulation of Calcitonin Gene-Related Peptide Secretion by a Serotonergic Antimigraine Drug

1999 • 185 citations

Botulinum Toxin Type A for the Prophylactic Treatment of Chronic Daily Headache: A Randomized, Double-Blind, Placebo-Controlled Trial

2005 • 178 citations

A Focused Review on the Use of Botulinum Toxins for Neuropathic Pain

2002 • 167 citations

Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors

2005 • 158 citations

Differential inhibition by botulinum neurotoxin A of cotransmitters released from autonomic vasodilator neurons

2001 • 137 citations

Botulinum Toxin a for Chronic Daily Headache: A Randomized, Placebo-Controlled, Parallel Design Study

2003 • 135 citations

Cervicogenic headache, migraine, and tension-type headache. Pressure-pain threshold measurements

1992 • 125 citations

Botulinum toxin A and the cutaneous nociception in humans: A prospective, double-blind, placebo-controlled, randomized study

2002 • 124 citations

Possible Mechanisms for the Effects of Botulinum Toxin on Pain

2002 • 122 citations

Inhibition of Release of Neurotransmitters from Rat Dorsal Root Ganglia by a Novel Conjugate of a Clostridium botulinumToxin A Endopeptidase Fragment and Erythrina cristagalliLectin

2002 • 121 citations

Effective treatment of frontal hyperhidrosis with botulinum toxin A

2000 • 110 citations

Flare and Hyperalgesia After Intradermal Capsaicin Injection in Human Skin

1998 • 108 citations

A randomized, double-blind, placebo controlled study on analgesic effects of botulinum toxin A

2003 • 100 citations

Treatment of Hyperfunctional Lines of the Face with Botulinum Toxin A

1998 • 99 citations

Treatment of Headache with Botulinum Toxin A—a Review According To Evidence-Based Medicine Criteria

2002 • 97 citations

Peripheral and central sensitization during migraine.

2000 • 97 citations

Mechanism of botulinum toxin in the relief of chronic pain

1999 • 95 citations

Botulinum toxin A in the treatment of headache syndromes and pericranial pain syndromes

2001 • 93 citations

Botulinum toxin type A in experimental neuropathic pain

2005 • 91 citations

Laser Doppler measurements of skin vasodilation elicited by percutaneous electrical stimulation of nociceptors in humans

1987 • 87 citations

Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin

2003 • 85 citations

Procedures for Administering Botulinum Toxin Type A for Migraine and Tension‐type Headache

2003 • 79 citations

Antinociceptive effect of botulinum toxin type a in rat model of carrageenan and capsaicin induced pain.

2005 • 71 citations

A Lack of Antinociceptive or Antiinflammatory Effect of Botulinum Toxin A in an Inflammatory Human Pain Model

2006 • 64 citations

Botulinum Toxin A Improved Burning Pain and Allodynia in Two Patients With Spinal Cord Pathology

2003 • 61 citations

The role of gustatory flushing in Frey's syndrome and its treatment with botulinum toxin type A

2002 • 55 citations

Review of botulinum toxin type A and its clinical applications in migraine headache

2001 • 51 citations

Measurement of cutaneous inflammatory reactions using a scanning laser-Doppler velocimeter

1991 • 49 citations

Interventional approaches to the management of myofascial pain syndrome

2001 • 48 citations

Thermography as a Means of Blood Perfusion Measurement

1979 • 43 citations

Neurogenic flare responses are heterogeneous in superficial and deep layers of human skin

1995 • 43 citations

A Focused Review of the Use of Botulinum Toxins for Low Back Pain

2002 • 38 citations

Botulinum Toxin and Other New Approaches to Migraine Therapy

2004 • 28 citations

The evolving management of migraine

2003 • 20 citations

Is there a role for botulinum toxin in the treatment of migraine?

2003 • 4 citations