Pathogenesis of schizophrenia: Part II. Temporo‐frontal two‐step hypothesis

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Vulnerability: A new view of schizophrenia.

1977 • 1,961 citations

Reflections on Language

1975 • 1,899 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Vulnerability: A new view of schizophrenia.

1977 • 1,817 citations

Meta-Analysis of Regional Brain Volumes in Schizophrenia

2000 • 1,657 citations

Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia

2000 • 1,565 citations

Dementia Praecox oder Gruppe der Schizophrenien

1911 • 1,368 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia

1992 • 1,173 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

The amygdala theory of autism

2000 • 1,097 citations

Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia

1999 • 1,063 citations

A Heuristic Vulnerability/Stress Model of Schizophrenic Episodes

1984 • 1,002 citations

The reduced neuropil hypothesis: a circuit based model of schizophrenia

1999 • 918 citations

A functional neuroanatomy of hallucinations in schizophrenia

1995 • 902 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

2000 • 884 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

Brain abnormality in schizophrenia

1998 • 859 citations

Increased Striatal Dopamine Transmission in Schizophrenia: Confirmation in a Second Cohort

1998 • 786 citations

Activation of Heschl’s Gyrus during Auditory Hallucinations

1999 • 741 citations

Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia

1990 • 737 citations

Postpubertal Emergence of Hyperresponsiveness to Stress and to Amphetamine after Neonatal Excitotoxic Hippocampal Damage: A Potential Animal Model of Schizophrenia

1993 • 690 citations

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

Mapping Auditory Hallucinations in Schizophrenia Using Functional Magnetic Resonance Imaging

2000 • 644 citations

Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia

1990 • 543 citations

Brain Morphology and Schizophrenia

1992 • 508 citations

Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11

1994 • 486 citations

Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents

1994 • 427 citations

Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia

1983 • 412 citations

Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and [¹²³I]Iomazenil

1998 • 411 citations

Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine

1995 • 357 citations

Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients

2000 • 340 citations

Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia

1993 • 338 citations

Life Events and Psychosis

1993 • 269 citations

THE LEFT MEDIAL TEMPORAL REGION AND SCHIZOPHRENIA: A PET STUDY

1992 • 264 citations

Dissociation between `theory of mind' and executive functions in a patient with early left amygdala damage

2001 • 264 citations

MOTILITY, BEHAVIOR AND THE BRAIN*

1948 • 229 citations

Volumes of Ventricular System Subdivisions Measured From Magnetic Resonance Images in First-Episode Schizophrenic Patients

1992 • 225 citations

Acute stress induces time-dependent responses in dopamine mesolimbic system

1991 • 213 citations

Schizophrenia: A Neuropathological Perspective

1991 • 206 citations

Prefrontal cortex, negative symptoms, and schizophrenia: an MRI study

2001 • 188 citations

Prefrontal Cortex and Schizophrenia

1995 • 170 citations

Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine.

1998 • 165 citations

Neurobiological Investigations in Cingulate Cortex of Schizophrenic Brain

1993 • 160 citations

Beyond the Dopamine Hypothesis

1989 • 155 citations

Left superior temporal blood flow increases in schizophrenic and schizophreniform patients with auditory hallucination: A longitudinal case study using123I-IMP SPECT

1993 • 154 citations

Multiple Limbic Regions Mediate the Disruption of Prepulse Inhibition Produced in Rats by the Noncompetitive NMDA Antagonist Dizocilpine

1998 • 148 citations

Model Generation and Testing to Probe Neural Circuitry in the Cingulate Cortex of Postmortem Schizophrenic Brain

1998 • 126 citations

Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: an 1 H-MR spectroscopy study

1999 • 124 citations

Entorhinal cortex pre-alpha cell clusters in schizophrenia: quantitative evidence of a developmental abnormality

2000 • 121 citations

Brain changes in schizophrenia

1998 • 99 citations

Motility, behavior, and the brain.

1946 • 94 citations

Early amygdala damage in the rat as a model for neurodevelopmental psychopathological disorders

2001 • 85 citations

A quantitative magnetic resonance imaging study of patients with schizophrenia

1993 • 80 citations

A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia

2002 • 72 citations

A Dopamine‐dependent Restitutive System for the Maintenance of Mental Normalcy

1986 • 49 citations

Aberrant Functional Organization in Schizophrenia: Analysis of EEG Coherence during Rest and Photic Stimulation in Drug-Naive Patients

1998 • 48 citations

Effects of D2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging

1998 • 37 citations

Interhemispheric EEG Coherence in Never-Medicated Patients with Paranoid Schizophrenia: Analysis at Rest and during Photic Stimulation

1998 • 37 citations

Effect of Mental Stress on Plasma Homovanillic Acid in Healthy Human Subjects

1998 • 36 citations

Influence of acute and chronic haloperidol treatment on dopamine metabolism in the rat caudate-putamen, prefrontal cortex and amygdala

1991 • 33 citations

Reduced metabolic response of the rat brain to haloperidol after chronic treatment

1985 • 32 citations

Excitatory Actions of NMDA Receptor Antagonists in Rat Entorhinal Cortex and Cultured Entorhinal Cortical Neurons

1999 • 29 citations

Neonatal lesions of the left entorhinal cortex affect dopamine metabolism in the rat brain

2000 • 29 citations

Expression of Fos protein in the limbic regions of the rat following haloperidol decanoate

1998 • 24 citations

Repeated Inescapable Stress Produces a Neuroleptic-like Effect on the Conditioned Avoidance Response

1995 • 18 citations

Differential Effects of Mental Stress on Plasma Homovanillic Acid in Schizophrenia and Normal Controls

1999 • 17 citations

Changes in limbic dopamine metabolism following quinolinic acid lesions of the left entorhinal cortex in rats

2000 • 15 citations

Comparative study of dopamine metabolism with local cerebral glucose utilization in rat brain following the administration of haloperidol decanoate

1994 • 14 citations

Schizophrenia: The Nature of the Psychological Disturbance and its Possible Neurochemical Basis

1979 • 10 citations

Parallel development of dopamine metabolism tolerance in the rat prefrontal cortex, caudate-putamen, and amygdala following haloperidol decanoate administration

1995 • 9 citations

Repeated Inescapable Stress Produces a Neuroleptic-like Effect on the Conditioned Avoidance Response

1995 • 6 citations

Effects of left entorhinal cortex lesion on stress-induced changes in dopamine function in the rat brain

2001 • 1 citations