Back to search

A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas

Data up to Jan 2025

Published2006
Citations317
References30

Total Citations Per Year

Abstract

References (30)

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

2000 • 15,583 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt

2006 • 2,463 citations

Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma

2004 • 958 citations

Streptozocin–Doxorubicin, Streptozocin–Fluorouracil, or Chlorozotocin in the Treatment of Advanced Islet-Cell Carcinoma

1992 • 948 citations

A Southwest Oncology Group study

1993 • 778 citations

Cancer: Principles and Practice of Oncology

2006 • 676 citations

mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

2005 • 621 citations

mTOR-targeted therapy of cancer with rapamycin derivatives

2005 • 607 citations

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten+/−mice

2001 • 574 citations

Phase II Study of Temozolomide and Thalidomide in Patients With Metastatic Neuroendocrine Tumors

2006 • 507 citations

Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel mTOR Inhibitor, in Patients With Cancer

2004 • 504 citations

Phase II Study of Temsirolimus (CCI-779), a Novel Inhibitor of mTOR, in Heavily Pretreated Patients With Locally Advanced or Metastatic Breast Cancer

2005 • 467 citations

Phase II/III Study of Doxorubicin With Fluorouracil Compared With Streptozocin With Fluorouracil or Dacarbazine in the Treatment of Advanced Carcinoid Tumors: Eastern Cooperative Oncology Group Study E1281

2005 • 351 citations

Combination chemotherapy trials in metastatic carcinoid tumor and the malignant carcinoid syndrome.

1979 • 280 citations

Octreotide as an antineoplastic agent in the treatment of functional and nonfunctional neuroendocrine tumors

1993 • 264 citations

Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor.

1984 • 262 citations

Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282

2001 • 179 citations

Carcinoid tumors and the carcinoid syndrome

1989 • 175 citations

Chemotherapy and biotherapy in the treatment of neuroendocrine tumours

2001 • 170 citations

Lack of Efficacy of Streptozocin and Doxorubicin in Patients With Advanced Pancreatic Endocrine Tumors

2004 • 122 citations

Phase II trial of dimethyltriazenoimidazole carboxamide in patients with metastatic carcinoid

1994 • 91 citations

Doxorubicin, Streptozocin, and 5-Fluorouracil Chemotherapy for Patients with Metastatic Islet-Cell Carcinoma

1998 • 90 citations

A phase 2 study to evaluate the efficacy and safety of SU11248 in patients (pts) with unresectable neuroendocrine tumors (NETs)

2005 • 76 citations

Phase II trial of doxorubicin therapy for advanced islet cell carcinoma.

1982 • 58 citations

Differential Expression of the PTEN Tumor Suppressor Protein in Fetal and Adult Neuroendocrine Tissues and Tumors: Progressive Loss of PTEN Expression in Poorly Differentiated Neuroendocrine Neoplasms

2002 • 57 citations

Improved progression free survival (PFS), and rapid, sustained decrease in tumor perfusion among patients with advanced carcinoid treated with bevacizumab

2005 • 56 citations

Phase II, 3-arm study of CCI-779 in combination with letrozole in postmenopausal women with locally advanced or metastatic breast cancer: preliminary results

2004 • 34 citations

Preliminary results of a phase II trial of gefitinib in progressive metastatic neuroendocrine tumors (NET): A Phase II Consortium (P2C) study

2005 • 26 citations

Untitled

2002 • 23 citations

Cited By (0)

Loading...
A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine… (2006) – British Journal of Cancer | Metascience Observatory Explorer