Bacterial resistances to inorganic mercury salts and organomercurials

Plasmid-Mediated Heavy Metal Resistances

1988 • 355 citations

Metal Ions in Biological Systems

1989 • 336 citations

Organization, Expression, and Evolution of Genes for Mercury Resistance

1986 • 319 citations

The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex

1989 • 286 citations

Mercuric reductase. Purification and characterization of a transposon-encoded flavoprotein containing an oxidation-reduction-active disulfide.

1982 • 267 citations

Molecular biology of the staphylococci

1991 • 261 citations

Deoxyribonucleic acid sequence of a gene from the Pseudomonas transposon TN501 encoding mercuric reductase

1983 • 232 citations

Structure of the detoxification catalyst mercuric ion reductase from Bacillus sp. strain RC607

1991 • 201 citations

The mercuric and organomercurial detoxifying enzymes from a plasmid-bearing strain of Escherichia coli.

1978 • 198 citations

The nucleotide sequence of the mercuric resistance operons of plasmid R100 and transposon Tn501: further evidence for mer genes which enhance the activity of the mercuric ion detoxification system

1986 • 152 citations

The MerR Metalloregulatory Protein Binds Mercuric Ion as a Tricoordinate, Metal-Bridged Dimer

1990 • 151 citations

Mercuric ion-resistance operons of plasmid R100 and transposon Tn501: the beginning of the operon including the regulatory region and the first two structural genes.

1984 • 150 citations

Ultrasensitivity and heavy-metal selectivity of the allosterically modulated MerR transcription complex.

1990 • 147 citations

Nucleotide sequence of a chromosomal mercury resistance determinant from a Bacillus sp. with broad-spectrum mercury resistance

1989 • 145 citations

Nucleotide sequence and expression of the mercurial-resistance operon from Staphylococcus aureus plasmid pI258.

1987 • 138 citations

Cloning and DNA sequence of the mercuric- and organomercurial-resistance determinants of plasmid pDU1358.

1987 • 136 citations

Mercuric reductase: homology to glutathione reductase and lipoamide dehydrogenase. Iodoacetamide alkylation and sequence of the active site peptide

1983 • 133 citations

Trigonal mercuric complex of an aliphatic thiolate: a spectroscopic and structural model for the receptor site in the mercury(II) biosensor MerR

1990 • 123 citations

Metalloregulatory DNA-binding Protein Encoded by the merR Gene: Isolation and Characterization

1987 • 121 citations

Tn5 insertion mutations in the mercuric ion resistance genes derived from plasmid R100

1983 • 116 citations

DNA distortion accompanies transcriptional activation by the metal-responsive gene-regulatory protein MerR

1990 • 116 citations

Transposon A-generated mutations in the mercuric resistance genes of plasmid R100-1

1979 • 112 citations

Transcriptional Regulation of the Mercury-resistance Genes of Transposon Tn501

1986 • 112 citations

Mechanistic studies of a protonolytic organomercurial cleaving enzyme: bacterial organomercurial lyase

1986 • 108 citations

Mercuric reductase structural genes from plasmid R100 and transposon Tn501: functional domains of the enzyme

1985 • 101 citations

Hypersensitivity to Hg2+ and hyperbinding activity associated with cloned fragments of the mercurial resistance operon of plasmid NR1

1979 • 97 citations

The Genetics and Biochemistry of Mercury Resistance

1987 • 96 citations

Coordination chemistry of the Hg-MerR metalloregulatory protein: evidence for a novel tridentate mercury-cysteine receptor site

1990 • 95 citations

Molecular basis of bacterial resistance to organomercurial and inorganic mercuric salts

1988 • 92 citations

Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase

1990 • 91 citations

Bacterial organomercurial lyase: overproduction, isolation, and characterization

1986 • 88 citations

Resistance to mercury and to cadmium in chromosomally resistant Staphylococcus aureus

1986 • 85 citations

Activator-dependent preinduction binding of .sigma.-70 RNA polymerase at the metal-regulated mer promoter

1990 • 85 citations

Phenotypic and genotypic adaptation of aerobic heterotrophic sediment bacterial communities to mercury stress

1986 • 83 citations

Homologous metalloregulatory proteins from both gram-positive and gram-negative bacteria control transcription of mercury resistance operons

1989 • 82 citations

Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase

1989 • 82 citations

Mercury operon regulation by the merR gene of the organomercurial resistance system of plasmid pDU1358

1989 • 81 citations

Genetic analysis of transcriptional activation and repression in the Tn21 mer operon

1989 • 80 citations

Site-specific insertion and deletion mutants in themerpromoter-operator region of Tn501; the nineteen base-pair spacer is essential for normal induction of the promoter by MerR

1990 • 77 citations

Bacterial resistance to mercury — reductio ad absurdum?

1985 • 77 citations

Role of the merT and merP gene products of transposon Tn501 in the induction and expression of resistance to mercuric ions

1987 • 76 citations

Purification and functional characterization of MerD. A coregulator of the mercury resistance operon in gram-negative bacteria.

1991 • 75 citations

Constitutive synthesis of a transport function encoded by the Thiobacillus ferrooxidans merC gene cloned in Escherichia coli

1990 • 72 citations

Regulation of transcription in Escherichia coli from the mer and merR promoters in the transposon Tn501

1989 • 65 citations

Mercuric reductase from R-plasmid NR1: characterization and mechanistic study

1983 • 64 citations

Transcriptional switching by the MerR protein: activation and repression mutants implicate distinct DNA and mercury(II) binding domains

1989 • 59 citations

Active site of mercuric reductase resides at the subunit interface and requires Cys135 and Cys140 from one subunit and Cys558 and Cys559 from the adjacent subunit: evidence from in vivo and in vitro heterodimer formation

1990 • 55 citations

Mutagenesis of the N- and C-terminal cysteine pairs of Tn501 mercuric ion reductase: consequences for bacterial detoxification of mercurials

1989 • 51 citations

Mutagenesis of the cysteines in the metalloregulatory protein MerR indicates that a metal-bridged dimer activates transcription

1989 • 50 citations

Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase

1985 • 50 citations

Solid-state mercury-199 nuclear magnetic resonance as a probe of coordination number and geometry in Hg(II) complexes

1990 • 50 citations

Mutagenesis of the redox-active disulfide in mercuric ion reductase: catalysis by mutant enzymes restricted to flavin redox chemistry

1989 • 46 citations

Down regulation of the mercury resistance operon by the most promoter-distal gene merD

1989 • 46 citations

Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction.

1986 • 44 citations

Overexpression and DNA-binding properties of the mer-encoded regulatory protein from plasmid NR1 (Tn21)

1987 • 41 citations

Some mercurial resistance plasmids from different incompatibility groups specify merR regulatory functions that both repress and induce the mer operon of plasmid R100

1985 • 39 citations

The reaction between NADPH and mercuric reductase from Pseudomonas aeruginosa.

1984 • 38 citations

Physical and genetic map of the organomercury resistance (Omr) and inorganic mercury resistance (Hgr) loci of the IncM plasmid R831b

1984 • 38 citations

The diversity of mercury reductases among mercury‐resistant bacteria

1988 • 37 citations

The distribution and divergence of DNA sequences related to the Tn21 and Tn501 mer operons

1988 • 35 citations

Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis

1991 • 34 citations

Identification of the merR gene of R100 by using mer-lac gene and operon fusions

1985 • 34 citations

Genes encoding mercuric reductases from selected gram-negative aquatic bacteria have a low degree of homology with merA of transposon Tn501

1990 • 32 citations

Bacterial organomercurial lyase: novel enzymic protonolysis of organostannanes

1988 • 29 citations

Purification, Crystallization, and Preliminary X-ray Diffraction Studies of the Flavoenzyme Mercuric Ion Reductase from Bacillus sp. Strain RC607

1989 • 28 citations

Deletion mutant analysis of the Staphylococcus aureus plasmid pI258 mercury-resistance determinant

1991 • 27 citations

Up-promoter mutations in the positively-regulatedmerpromoter of TnSOl

1989 • 25 citations

Biotechnology: Bridging research and applications

1992 • 21 citations

Metalloregulatory proteins and molecular mechanisms of heavy metal signal transduction.

1990 • 19 citations

Bacterial Heavy Metal Resistance Systems and Possibility of Bioremediation

1991 • 18 citations

Deletions in the r-determinant mer region of plasmid R100-1 selected for loss of mercury hypersensitivy

1979 • 15 citations

Transcriptional analysis of the Staphylococcus aureus plasmid pI258 mercury resistance determinant

1991 • 10 citations

Metalloregulatory Proteins: Metal Responsive Molecular Switches Governing Gene Expression

1989 • 9 citations

Regulation of gene expression by mercury.

1990 • 6 citations