N,N-Dimethyltryptamine: An Endogenous Hallucinogen

Public Health Service

1963 • 3,764 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Psychopharmacology. A Review of Progress, 1957-1967

1969 • 844 citations

Psychopharmacology. A Generation of Progress

1978 • 668 citations

Schizophrenia: A New Approach

1952 • 469 citations

Mammalian methylenetetrahydrofolate reductase Partial purification, properties, and inhibition by S-adenosylmethionine

1971 • 349 citations

A possible correlation between drug-induced hallucinations in man and a behavioural response in mice

1967 • 250 citations

Neuroregulators and psychiatric disorders

1978 • 233 citations

Progress in Neurobiology

1957 • 212 citations

Dimethyltryptamin: Its metabolism in man; the relation of its psychotic effect to the serotonin metabolism

1956 • 193 citations

The pharmacology and biochemistry of N-oxides.

1969 • 193 citations

The enzymatic N-methylation of serotonin and other amines.

1962 • 184 citations

Psychotomimetic N -Methylated Tryptamines: Formation in Brain in vivo and in vitro

1972 • 181 citations

Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds

1961 • 178 citations

Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors

1975 • 166 citations

Pituitary Gland: Enzymic Formation of Methanol from S -Adenosylmethionine

1965 • 159 citations

Neuroregulators and Psychiatric Disorders

1978 • 158 citations

Observations on the fate of indolalkylamines in the organism

1955 • 146 citations

LSD as an agonist of dopamine receptors in the striatum

1974 • 129 citations

Indole(ethyl)amine N-Methyltransferase in Human Brain

1971 • 126 citations

Effects of 5-methoxy-N,N-dimethyltryptamine on central monoamine neurons

1972 • 121 citations

The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine

1976 • 120 citations

THE DISTRIBUTION AND PROPERTIES OF THE NONSPECIFIC N‐METHYLTRANSFERASE IN BRAIN

1973 • 116 citations

EFFECTS OF METHIONINE LOADING ON THE BEHAVIOR OF SCHIZOPHRENIC PATIENTS

1962 • 112 citations

Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain.

1976 • 109 citations

The administration of methionine to chronic schizophrenic patients: a review of ten studies.

1974 • 107 citations

Psychotomimetic drugs and brain 5-hydroxytryptamine metabolism

1970 • 105 citations

Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. II. Distribution and characteristics of dopamine adenylate cyclase — Interaction of d-LSD with dopaminergic receptors

1976 • 102 citations

Hallucinogenic drugs of the indolealkylamine type and central monoamine neurons.

1971 • 101 citations

A Dimethyltryptamine-Forming Enzyme in Human Blood

1973 • 101 citations

Methyltetrahydrofolic Acid Mediates N - and O -Methylation of Biogenic Amines

1973 • 100 citations

The effects of some hallucinogenic drugs upon the metabolism of noradrenaline

1969 • 89 citations

5-Methyltetrahydrofolic Acid as a Mediator in the Formation of Pyridoindoles

1974 • 83 citations

Indole(ethyl)amine N -Methyltransferase in the Brain

1969 • 81 citations

THE ROLE OF VITAMIN B₁₂ IN METHYL TRANSFER TO HOMOCYSTEINE*

1964 • 81 citations

Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase

1975 • 77 citations

Oxidative N-dealkylation

1955 • 72 citations

Hydroxylation and N-demethylation of N,N-dimethyltryptamine

1959 • 72 citations

Interactions between lysergic acid diethylamide and dopamine-sensitive adenylate cyclase systems in rat brain

1975 • 71 citations

The Mode of Action Of 5-Hydroxytryptamine

1972 • 71 citations

Blood and urine levels of N,N-dimethyltryptamine following administration of psychoactive dosages to human subjects

1974 • 67 citations

Tryptoline Formation by a Preparation from Brain with 5-Methyltetrahydrofolic Acid and Tryptamine

1975 • 67 citations

Metabolism of the hallucinogen N,N-dimethyltryptamine in rat brain homogenates

1980 • 65 citations

ENZYMATIC FORMATION OF TETRAHYDRO-?-CARBOLINE FROM TRYPTAMINE AND 5-METHYLTETRAHYDROFOLIC ACID IN RAT BRAIN FRACTIONS: REGIONAL AND SUBCELLULAR DISTRIBUTION

1975 • 62 citations

Ethnopharmacology of Sacred Psychoactive Plants Used by the Indians of Mexico

1977 • 62 citations

5-hydroxytryptamine binding to synaptic membranes from rat brain

1976 • 62 citations

Studies on the Mechanism of Action of Monoamine Oxidase: Metabolism of N,N-Dimethyltryptamine and N,N-Dimethyltryptamine-N-Oxide

1962 • 57 citations

The effect of N,N-dimethyltryptamine in human subjects tolerant to lysergic acid diethylamide

1964 • 56 citations

Triptolines

1974 • 56 citations

Stereospecific receptor sites for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists, and other psychotropic drugs.

1976 • 54 citations

ENZYMATIC FORMATION OF TETRAHYDRO-?-CARBOLINE FROM TRYPTAMINE AND 5-METHYLTETRAHYDROFOLIC ACID IN RAT BRAIN FRACTIONS: REGIONAL AND SUBCELLULAR DISTRIBUTION

1975 • 54 citations

High-affinity 3H-serotonin binding to caudate: Inhibition by hallucinogens and serotoninergic drugs

1978 • 54 citations

Multiple N-methytransferases for aromatic alkylamines in brain

1973 • 53 citations

The in vitro identification of dimethyltryptamine (DMT) in mammalian brain and its characterization as a possible endogenous neuroregulatory agent

1977 • 53 citations

Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man

1963 • 51 citations

Gas chromatographic-mass spectrometric isotope dilution determination of N,N-dimethyltryptamine concentrations in normals and psychiatric patients

1973 • 49 citations

Dimethyltryptamin: ein neues Psychoticum

1958 • 49 citations

N-Methylation of biogenic amines—I

1974 • 45 citations

Liver metabolic reactions: Tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation

1972 • 45 citations

Failure of N,N-dimethyltryptamine to evoke tolerance in cats.

1973 • 40 citations

Determination and physiological disposition of dimethyltryptamine and diethyltryptamine in rat brain, liver and plasma

1972 • 39 citations

Comparative effects of hallucinogenic drugs on rotational behavior in rats with unilateral 6-hydroxydopamine lesions

1977 • 39 citations

5-methyltetrahydrofolate aromatic alkylamine n-methyltransferase: An artefact of 5, 10-methylenetetrahydrofolate reductase activity

1975 • 38 citations

Purification and substrate specificity of indoleamine-N-methyl transferase

1971 • 37 citations

Conversion of C14-S-adenosylmethionine to C14- formaldehyde and condensation with indoleamines: A side reaction in N-methyltransferase assay in blood

1974 • 37 citations

Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogs

1978 • 36 citations

On the mode of formation of tetrahydro-β-carbolines

1976 • 35 citations

Inhibition of indolethylamine-N-methyltransferase by analogs of S-adenosylhomocysteine

1975 • 35 citations

A Review of Recent Studies of the Biosynthesis and Excretion of Hallucinogens Formed by Methylation of Neurotransmitters or Related Substances

1976 • 34 citations

Inhibition of indolethylamine-N-methyltransferase by S-Adenosylhomocysteine

1973 • 33 citations

Liver metabolic reactions: Tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction and N-oxide N-dealkylation

1973 • 32 citations

The effects of N,N-dimethyltryptamine on operant behavior in squirrel monkeys

1973 • 32 citations

Methylenetetrahydrofolate reductase in the rat central nervous system: Intracellular and regional distribution

1975 • 31 citations

Identification of N5,N10-methylene tetrahydrofolate reductase as the enzyme involved in the 5-methyl tetrahydrofolate-dependent formation of a β-carboline derivative of 5-hydroxytryptamine in human platelets

1976 • 28 citations

Enzymatic formaldehyde production from 5-methyltetrahydrofolic acid: Prior step to alkaloid formation

1975 • 27 citations

Effect of N,N-Dimethyltryptamine and D-Lysergic Acid Diethylamide on the Release of 5-Hydroxyindoles in Rat Forebrain

1971 • 27 citations

THE NATURE OF THE BINDING BETWEEN LSD AND A 5‐HT RECEPTOR: A POSSIBLE EXPLANATION FOR HALLUCINOGENIC ACTIVITY

1974 • 26 citations

The Dimethyltryptamine-Forming Enzyme in Blood Platelets: A Study in Monozygotic Twins Discordant for Schizophrenia

1973 • 24 citations

Biological activities of some 5-substituted N,N-dimethyltryptamines, ?-methyltryptamines, and gramines

1970 • 23 citations

A peptide-like inhibitor of N-methyltransferase in rabbit brain

1977 • 22 citations

Binding of d-Lysergic Acid Diethylamide to Subcellular Fractions from Rat Brain

1972 • 21 citations

The Oxidative Deamination of Serotonin and Other 3-(beta-Aminoethyl)-indoles by Monamine Oxidase and the Effect of These Compounds on the Deamination of Tyramine

1953 • 21 citations

Neurochemical investigations of the interaction of N,N-dimethyltryptamine with the dopaminergic system in rat brain

1977 • 21 citations

Behavioral effects and metabolic fate of N,N-dimethyltryptamine in mice pretreated with β-diethylaminoethyl-diphenylpropylacetate (SKF 525-A), iproniazid and chlorpromazine

1978 • 20 citations

N,N-dimethyltryptamine lowers rat brain acetylcholine and dopamine

1977 • 19 citations

Indolethylamine‐N‐methyltransferase in developing rabbit lung

1974 • 19 citations

The formation of β‐carboline alkaloids mediated by serine hydroxymethyltransferase

1979 • 18 citations

Substrate specificity and heterogeneity of N-methyltransferases

1972 • 18 citations

Behavioural Effects of some Derivatives of Amphetamine and LSD and their Significance

1970 • 18 citations

Accumulation of N,N-dimethyltryptamine in rat brain cortical slices.

1979 • 16 citations

Selective and specific thin-layer chromatographic, gas chromatographic and gas chromatographic-mass spectrometric methods for the assay of indolethylamine N-methyltransferase activity

1973 • 15 citations

Increased synthesis of striatal dopamine by N,N-dimethyltryptamine

1977 • 15 citations

Affinity chromatography of an S-adenosylmethionine-dependent methyltransferase using immobilized S-adenosylhomocysteine

1978 • 14 citations

ENZYMATIC N‐METHYLATION OF INDOLEAMINES BY MAMMALIAN BRAIN: FACT OR ARTEFACT?

1976 • 13 citations

Tryptamine-N-methyltransferase activity in brain tissue: a re-examination

1976 • 12 citations

Dose response and time course effects of N,N-dimethyltryptamine on disruption of rat shuttlebox avoidance.

1977 • 12 citations

Effects of N,N-dimethyltryptamine on electrically evoked responses in the cat visual system and modification by neuroleptic agents

1976 • 11 citations

LACK OF ENHANCEMENT OF DIMETHYLTRYPTAMINE FORMATION IN RAT BRAIN AND RABBIT LUNG IN VIVO BY METHIONINE OR S‐ADENOSYLMETHIONINE

1978 • 11 citations

N-methylation of 1-methyltryptamines by indolethylamine N-methyltransferase

1975 • 10 citations

Enzymic 6-hydroxylation of indolealkylamines and related compounds

1968 • 10 citations

Inhibition of indoleamine-N-methyltransferase by 2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine

1976 • 9 citations

Inhibition of indolethylamine-N-methyltransferase by aliphatic diamines

1977 • 9 citations

Formation of 1,2,3,4-tetrahydro-β-carboline and methylene-β-phenylethylimine from 5-methyltetrahydrofolate and amines in tissues from developing rat brain

1976 • 9 citations

Effects of certain indoleamines in the hippocampal-septal circuit

1975 • 8 citations

Comparative studies of indolethylamine-N-methyl transferase activity by thin-layer chromatographic, gas chromatographic, gas chromatographic-mass spectrometric and radiometric methods

1974 • 8 citations

Participation of retinal mechanisms in DMT hallucinations

1973 • 7 citations

The lack of correlation between hallucinogenesis and inhibition of axoplasmic transport.

1974 • 7 citations

Plasma indolethylamine-n-methyltransferase activity and growth hormone level during sleep: a pilot study.

1977 • 6 citations

Possible source of error in studies of enzymatic formation of dimethyltryptamine

1976 • 5 citations

Inhibition of dimethyltryptamine biosynthesis by N,N'-bis-(3-methyl-2-thiazolidinylidene)succinamide (I) and 2-imino-3-methylthiazolidine (II).

1978 • 4 citations