Differentiation of the drug‐binding sites of calmodulin

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

1977 • 544 citations

Calcium-induced exposure of a hydrophobic surface on calmodulin

1980 • 520 citations

Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.

1982 • 516 citations

Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.

1980 • 335 citations

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase

1986 • 319 citations

Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

1982 • 259 citations

Interaction of the antihypertensive drug felodipine with calmodulin

1981 • 251 citations

Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme.

1979 • 244 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

The enzymatic preparation of [alpha-32P]ATP, [alpha-32P]GTP, [32P]cAMP, and [32P]cGMP, and their use in the assay of adenylate and guanylate cyclases and cyclic nucleotide phosphodiesterases.

1979 • 178 citations

A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.

1978 • 171 citations

Calcium antagonist subgroups

1985 • 160 citations

Stimulation of the purified erythrocyte Ca2+-ATPase by tryptic fragments of calmodulin.

1984 • 151 citations

Characterization of tryptic fragments obtained from bovine brain protein modulator of cyclic nucleotide phosphodiesterase.

1977 • 142 citations

Chemical synthesis and expression of a calmodulin gene designed for site-specific mutagenesis

1985 • 140 citations

Kinetics of calcium dissociation from calmodulin and its tryptic fragments. A stopped-flow fluorescence study using Quin 2 reveals a two-domain structure

1985 • 137 citations

A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands

1983 • 129 citations

Cadmium-113 nuclear magnetic resonance studies of proteolytic fragments of calmodulin: assignment of strong and weak cation binding sites

1983 • 119 citations

Purification of myosin light chain kinase from bovine cardiac muscle.

1980 • 109 citations

Calcium‐dependent hydrophobic interaction chromatography of calmodulin, troponin C and their proteolytic fragments

1983 • 92 citations

Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins

1985 • 88 citations

3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, a hydrophobic, photoreactive probe, labels calmodulin and calmodulin fragments in a calcium(2+)-dependent way

1984 • 80 citations

Stimulation of enzyme activities by fragments of calmodulin

1981 • 75 citations

Calcium Binding to Tryptic Fragments of Calmodulin1

1984 • 74 citations

The nature of the trifluoperazine binding sites on calmodulin and troponin-C

1984 • 58 citations

Selective effects of CAPP1-calmodulin on its target proteins

1985 • 56 citations

Localization of a trifluoperazine binding site on troponin C

1983 • 53 citations

A¹¹³Cd and ¹H NMR Study of the Interaction of Calmodulin with D600, Trifluoperazine and Some Other Hydrophobic Drugs

1983 • 47 citations

Uptake of bepridil into isolated ventricular myocytes

1983 • 44 citations

Cooperativity among calmodulin drug binding sites

1985 • 44 citations

Calmodulin antagonists inhibit activity of myosin light‐chain kinase independent of calmodulin

1984 • 36 citations

Drug protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin

1985 • 34 citations

The synthesis and reaction of a specific affinity label for the hydrophobic drug-binding domains of calmodulin.

1984 • 31 citations

Functional properties of covalent .beta.-endorphin peptide/calmodulin complexes. Chlorpromazine binding and phosphodiesterase activation

1985 • 31 citations

Calcium release from calmodulin and its C‐terminal or N‐terminal halves in the presence of the calmodulin antagonists phenoxybenzamine and melittin measured by stopped‐flow fluorescence with Quin 2 and intrinsic tyrosine

1986 • 27 citations

The binding of the calcium channel blocker, bepridil, to calmodulin

1986 • 27 citations

Inhibition of Turkey gizzard myosin light chain

1984 • 27 citations

Localization of felodipine (dihydropyridine) binding site on calmodulin

1986 • 19 citations

Calmodulin activates bovine-cardiac myosin light-chain kinase by increasing the affinity for myosin light-chain 2

1984 • 12 citations