Respiratory depression and spinal opioids

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Intrathecal and Epidural Administration of Opioids

1984 • 1,198 citations

TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION

1982 • 1,169 citations

Epidural Anesthesia and Analgesia in High-risk Surgical Patients

1987 • 1,003 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Pain Relief by Intrathecally Applied Morphine in Man

1979 • 944 citations

Applied Respiratory Physiology

1994 • 745 citations

Sleep Apnea, Hypopnea and Oxygen Desaturation in Normal Subjects

1979 • 640 citations

EPIDURAL MORPHINE IN TREATMENT OF PAIN

1979 • 637 citations

Obstetrics and Gynecology

2023 • 560 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

Postoperative recovery of pulmonary function.

1981 • 550 citations

MOLECULAR BASIS FOR MILD FORMS OF HOMOZYGOUS BETA-THALASSAEMIA

1981 • 487 citations

Development of an Anesthesiology-based Postoperative Pain Management Service

1988 • 454 citations

Pronounced, Episodic Oxygen Desaturation in the Postoperative Period

1985 • 435 citations

[Control of breathing during sleep].

1983 • 363 citations

Sleep in Chronic Obstructive Lung Disease

1985 • 358 citations

Changes in tidal volume, frequency, and ventilation induced by their measurement.

1972 • 352 citations

Diminished Ventilatory Response to Hypoxia and Hypercapnia after Morphine in Normal Man

1975 • 345 citations

ADVERSE EFFECTS OF EXTRADURAL AND INTRATHECAL OPIATES: REPORT OF A NATIONWIDE SURVEY IN SWEDEN

1982 • 343 citations

Validation of respiratory inductive plethysmography using different calibration procedures.

1982 • 343 citations

Rostral Spread of Epidural Morphine

1982 • 342 citations

TRANSIENT HYPOXÆMIA DURING SLEEP IN CHRONIC BRONCHITIS AND EMPHYSEMA

1979 • 308 citations

The Physiology and Pharmacology of Spinal Opiates

1985 • 303 citations

Postthoracotomy Pain and Pulmonary Function Following Epidural and Systemic Morphine

1984 • 248 citations

Disturbed sleep and prolonged apnea during nasal obstruction in normal men.

1981 • 241 citations

Opiate Receptors and Internal Opiates

1977 • 241 citations

Deaf-mutism and type-II hyperlipoproteinaemia.

1970 • 225 citations

Epidural Morphine for Postoperative Pain: Experience with 1085 Patients

1985 • 219 citations

SPLANCHNIC OXYGEN CONSUMPTION AND SUBSTRATE RALANCE FOLLOWING ACCIDENTAL INJURY

1984 • 217 citations

Opiate Receptors in the Brain

1977 • 210 citations

PRESENT STATE OF EXTRADURAL AND INTRATHECAL OPIOID ANALGESIA IN SWEDEN

1987 • 207 citations

Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat

1978 • 207 citations

Respiratory Dysrhythmias during Sleep

1981 • 204 citations

Ventilatory Responses to Hypoxia and Hypercapnia during Halothane Sedation and Anesthesia in Man

1978 • 204 citations

SPRUE AGAIN

1975 • 198 citations

Decrease in functional residual capacity during sleep in normal humans

1984 • 175 citations

Mini-Dose Intrathecal Morphine for the Relief of Post-Cesarean SectionPain

1988 • 174 citations

Transient Hypoxemia during Sleep in Chronic Obstructive Pulmonary Disease Is Not a Sleep Apnea Syndrome^1–3

1983 • 173 citations

THE ÆTIOLOGY OF RETROGRADE AMNESIA

1971 • 173 citations

DURAL PERMEABILITY TO NARCOTICS: IN VITRO DETERMINATION AND APPLICATION TO EXTRADURAL ADMINISTRATION

1982 • 172 citations

Increases in Intracranial Pressure from Succinylcholine

1986 • 168 citations

The neuropharmacology of respiratory control.

1982 • 148 citations

The respiratory inductive plethysmograph: a new non-invasive monitor of respiration.

1982 • 145 citations

Chronic obstructive airflow disease and sleep studies.

1980 • 144 citations

Respiratory depression after intrathecal narcotics

1980 • 138 citations

Myxedema and obstructive sleep apnea

1981 • 132 citations

Breathing Pattern Abnormalities and Arterial Oxygen Desaturation during Sleep in the Congestive Heart Failure Syndrome

1987 • 127 citations

Postoperative pain control with intrathecal morphine

1981 • 124 citations

Respiratory Depression After Epidural Morphine???An Experimental and Clinical Study

1984 • 123 citations

Delayed Respiratory Depression in a Child after Caudal Epidural Morphine

1988 • 123 citations

Pharmacokinetics of Epidural Morphine and Meperidine in Humans

1987 • 121 citations

Ventilatory CO2 Sensitivity after Intravenous and Epidural Morphine in Volunteers

1983 • 116 citations

EXTRADURAL OPIOIDS FOR POSTOPERATIVE ANALGESIA

1981 • 114 citations

Intrathecal morphine: naloxone reverses respiratory depression but not analgesia.

1980 • 112 citations

Influence of Naloxone Infusion on Analgesia and Respiratory Depression Following Epidural Morphine

1986 • 108 citations

Cephalad migration of morphine in CSF following lumbar epidural administration in patients with cancer pain

1985 • 108 citations

Epidural Morphine in Children: Pharmacokinetics and CO2 Sensitivity

1986 • 100 citations

Breathing During Sleep in Normal Subjects

1985 • 100 citations

ASSESSMENT OF THE EFFECTS OF DRUGS ON RESPIRATION

1982 • 99 citations

Control of Ventilation During Sleep

1985 • 92 citations

Continuous epidural infusion of morphine for treatment of pain after thoracic surgery: a new technique.

1984 • 91 citations

Obstructive Sleep Apnea Associated With Tonsillar Hypertrophy in Adults

1981 • 91 citations

The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine

1987 • 90 citations

POSTOPERATIVE CHANGES IN GAS TENSIONS OF ARTERIAL BLOOD AND IN VENTILATORY FUNCTION

1966 • 87 citations

Ventilatory depression related to plasma fentanyl concentrations during and after anesthesia in humans.

1983 • 87 citations

The respiratory depression of epidural morphine

1982 • 86 citations

Comparison of epidural fentanyl with sufentanil

1987 • 84 citations

Pharmacokinetic aspects of spinal morphine analgesia

1984 • 84 citations

POSTOPERATIVE SPINAL ANALGESIA WITH MORPHINE

1981 • 83 citations

Serum Levels Following Epidural Administration of Morphine and Correlation with Relief of Postsurgical Pain

1981 • 82 citations

Ventilation and chemoreflexes during enflurane sedation and anaesthesia in man

1979 • 81 citations

Applied Respiratory Physiology

1988 • 80 citations

Chemical control of ventilation and sleep arterial oxygen desaturation in patients with COPD.

1980 • 80 citations

Epidural Morphine for Postoperative Pain Relief

1982 • 80 citations

Epidural morphine causes delayed and prolonged ventilatory depression

1981 • 79 citations

Epidural Butorphanol or Morphine for the Relief of Post-Cesarean Section Pain

1987 • 79 citations

Ventilatory Depression Related to Plasma Fentanyl Concentrations during and after Anesthesia in Humans

1983 • 78 citations

Biphasic Depression of Ventilatory Responses to CO2 Following Epidural Morphine

1983 • 76 citations

Oxygen Saturation during Breath-Holding and during Apneas in Sleep

1984 • 75 citations

The Effect of Sleep Plus Morphine on the Respiratory Response to Carbon Dioxide

1964 • 75 citations

Lecture notes in medical informatics

1980 • 73 citations

Evaluation of interface potential barrier heights between ultrathin silicon oxides and silicon

1985 • 72 citations

Sleep apnea in acromegaly

1980 • 72 citations

Neural Control of Respiration

1958 • 71 citations

CSF distribution of morphine, methadone and sucrose after intrathecal injection

1985 • 70 citations

CONTINUOUS EPIDURAL PENTANYL ANALGESIA

1986 • 70 citations

PLASMA FENTANYL CONCENTRATIONS AND THE OCCURRENCE OF RESPIRATORY DEPRESSION IN VOLUNTEERS

1982 • 69 citations

Postoperative analgesia in major orthopaedic surgery

1981 • 61 citations

Meperidine as a spinal anesthetic agent: a comparison with lidocaine-glucose.

1987 • 61 citations

Analgesic and Respiratory Effects of Epidural Sufentanil in Patients Following Thoracotomy

1988 • 60 citations

Comparison of different methods of postoperative analgesia after thoracotomy

1986 • 60 citations

Ventilatory and arousal patterns during sleep in normal young and elderly subjects

1985 • 60 citations

Determinants of oxygen desaturation in the course of ventilation during sleep in chronic obstructive pulmonary disease.

1980 • 59 citations

Clinical Advantages of Fentanyl Given Epidurally for Postoperative Analgesia

1984 • 59 citations

Opiate system influences central respiratory chemosensors

1981 • 59 citations

Hypersomnia With Periodic Apneas in Acquired Micrognathia

1976 • 59 citations

Epidural sufentanil for postoperative pain relief

1985 • 59 citations

Ventilatory Response to Carbon Dioxide After Intramuscular and Epidural Fentanyl

1988 • 58 citations

Epidural Pentazocine for Postoperative Pain Relief

1984 • 56 citations

Continuous Epidural Fentanyl Analgesia

1987 • 56 citations

Respiratory inductance plethysmography: calibration techniques, their validation and the effects of posture.

1985 • 55 citations

Nalbuphine Augmentation of Analgesia and Reversal of Side Effects Following Epidural Hydromorphone

1986 • 53 citations

The sleep apnoea syndrome and epidural morphine

1986 • 52 citations

Respiratory effects of epidural fentanyl

1985 • 52 citations

Ventilatory Response to Carbon Dioxide after Intra muscular and Epidural Fentanyl

1987 • 52 citations

Epidural Pentazocine for Postoperative Pain Relief

1983 • 51 citations

Sleep apneic activity in older healthy subjects

1985 • 49 citations

Epidural morphine prophylaxis of postoperative pain: report of a double-blind multicentre study

1985 • 48 citations

Epidural morphine analgesia after cesarean delivery.

1984 • 46 citations

The Effect of Drugs on Respiration in Man

1985 • 44 citations

Analgesia and Ventilatory Response to CO2 Following Epidural Sufentanil in Children

1987 • 44 citations

Subjective and Objective Measurement of Tidal Volume in Critically III Patients

1985 • 44 citations

Pharmacokinetics in anaesthesia

1983 • 44 citations

Epidural Morphine

1985 • 41 citations

Respiratory depression following epidural morphine: A clinical study

1986 • 40 citations

Meperidine as a Spinal Anesthetic Agent

1987 • 39 citations

Sleep Arterial Oxygen Desaturation and Chemical Control of Breathing during Wakefulness in COPD

1986 • 38 citations

Clinical Experience with Epidural Morphine

1981 • 37 citations

Epidural morphine in the elderly.

1982 • 36 citations

EPIDURAL MORPHINE SULFATE FOR ANALGESIA AFTER CESAREAN SECTION

1986 • 36 citations

Age Predicts Effective Epidural Morphine Dose after Abdominal Hysterectomy

1987 • 36 citations

Pain Relief and Plasma Concentrations from Epidural and Intramuscular Morphine in Post-Cesarean Patients

1982 • 36 citations

Treatment of Intrathecal Morphine Overdose by Aspiration of Cerebrospinal Fluid

1987 • 36 citations

CLINICAL ASSESSMENT AND PLASMA PHARMACOKINETICS ASSOCIATED WITH INTRAMUSCULAR OR EXTRADURAL ALFENTANIL

1985 • 35 citations

Extradural versus intramuscular diamorphine

1983 • 35 citations

Epidural and intrathecal narcotics

1983 • 34 citations

Epidural morphine provides postoperative pain relief in peripheral vascular and orthopedic surgical patients: a dose-response study.

1986 • 34 citations

Analgesic and Cardiorespiratory Effects of Epidural Sufentanil and Morphine in Humans

1988 • 34 citations

Morphine, pentobarbital and naloxone in the ventral medullary chemosensitive areas: differential respiratory and cardiovascular effects.

1982 • 34 citations

Age Predicts Effective Epidural Morphine Dose After Abdominal Hysterectomy

1988 • 33 citations

Postoperative pain relief with high‐dose epidural buprenorphine: a double‐blind study

1986 • 33 citations

ALTERATION OF BLOOD COMPONENTS WITH HEMODILUTION AND ADMINISTRATION OF WASHED SHED RED CELLS

1988 • 33 citations

Epidural Morphine Following Epidural Local Anesthesia

1981 • 33 citations

Epidural morphine following epidural local anesthesia: effect on ventilatory and airway occlusion pressure responses to CO2.

1981 • 33 citations

Profound Central Nervous System Depression from Epidural Fentanyl for Extracorporeal Shock Wave Lithotripsy

1987 • 32 citations

Forum

1981 • 32 citations

EXTRADURAL MORPHINE FOR PAIN AFTER SURGERY

1981 • 31 citations

Respiratory aspects of anaesthesia

1987 • 30 citations

Morphine Concentration in Brain and Spinal Cord after Subarachnoid Injection in Baboons

1985 • 29 citations

A Comparison of Epidural Morphine and Epidural Bupivacaine for Postoperative Pain Relief

1981 • 28 citations

Ventilatory effects of pre‐ and postoperative diamorphine

1984 • 28 citations

Awake Abnormalities of Control of Breathing and of the Upper Airway

1984 • 27 citations

MEASUREMENT OF THE RELATIVE CONTRIBUTIONS OF RIB CAGE AND ABDOMEN/DIAPHRAGM TO TIDAL BREATHING IN MAN

1979 • 22 citations

The role of endogenous peptides in the action of opioid analgesics

1986 • 21 citations

HALOTHANE, PER SE, DOES NOT CAUSE ISCHEMIC MYOCARDIAL DYSFUNCTION IN THE PRESENCE OF CORONARY STENOSIS

1985 • 21 citations

Neurologic Depression after Intrathecal Morphine

1981 • 20 citations

Effect of Prophylactic Epidural Morphine or Bupivacaine on Postoperative Pain after Upper Abdominal Surgery

1982 • 20 citations

Clinical Application of Epidural and Intrathecal Opioids for Pain Management

1986 • 19 citations

RELATIONSHIP OF VENTILATORY DEPRESSION TO STEADY-STATE BLOOD PETHIDINE CONCENTRATIONS

1981 • 19 citations

Epidural meperidine-bupivacaine for obstetric analgesia.

1982 • 18 citations

Opioid Analgesics and Antagonists

2011 • 17 citations

Spinal narcotics and central nervous system depression

1981 • 17 citations

CONTINUOUS EPIDURAL FENTANYL

1985 • 17 citations

Pupillary Diameter and Ventilatory CO2 Sensitivity after Epidural Morphine and Buprenorphine in Volunteers

1987 • 15 citations

Canopy ventilation monitor for quantitative measurement of ventilation during sleep

1980 • 14 citations

Respiratory Depression and Morphine Concentration in Serum after Epidural and Intramuscular Administration of Morphine

1982 • 14 citations

Epidural sufentanil versus intramuscular buprenorphine for postoperative analgesia

1987 • 14 citations

Respiratory depression following postoperative analgesia with epidural morphine

1986 • 13 citations

CONTROLLED COMPARISON OF INTRATHECAL CINCHOCAINE WITH INTRATHECAL CINCHOCAINE AND MORPHINE

1984 • 13 citations

Respiratory Depression after Single Epidural Injection of Local Anesthetic and Morphine

1987 • 12 citations

Complication of epidural morphine.

1980 • 11 citations

Control of breathing

1987 • 10 citations

Epidural and intrathecal opiates in obstetrics.

1984 • 10 citations

Intermittent epidural morphine instillation for control of postoperative pain

1983 • 9 citations

Respiratory depression complicating epidural diamorphine

1985 • 9 citations

COMPARATIVE ANALGESIC EFFICACY OF EPIDURAL NALBUPHINE, BUTORPHANOL, MEPERIDINE AND MORPHINE

1988 • 9 citations

ESHOLOL INFUSION DURING NITROPRUSSIDE-INDUCED HYPOTENSION

1988 • 8 citations

Central Sleep Apnea

1985 • 7 citations

EFFECT OF INTRAVENOUSLY ADMINISTERED LIDOCAINE ON TOURNIQUET INDUCED HYPERTENSION UNDER GENERAL ANESTHESIA

1986 • 7 citations

AN ACTIVITY ANALYSIS OF THE ANESTHESIOLOGIST'S INTEROPERATIVE TIME PERIOD

1984 • 7 citations

LACK OF ADVERSE NEUROBEHAVIORAL EFFECTS OF LIDOCAINE

1982 • 7 citations

C02 SENSITIVITY AFTER EPIDURAL FENTANYL

1985 • 7 citations

Carbon dioxide response after epidural morphine

1982 • 7 citations

LUMBAR EPIDURAL ANALGESIA POST-THORACIC SURGERY

1988 • 7 citations

Sites and mechanisms of basic narcotic receptor function based on current research

1986 • 6 citations

Ventilatory failure

1987 • 4 citations

ANALGESIA AND VENTILATORY CONTROL AFTER INTRAMUSCULAR AND EPIDURAL ALFENTANIL

1986 • 4 citations

Monitoring the Respiratory Effects of Analgesic Drugs in the Postoperative Period

1983 • 3 citations

Clinical evidence for different narcotic receptors and relevance for the clinician

1986 • 3 citations

ANALGESIC AND RESPIRATORY EFFECTS OF EPIDURAL SUFENTANIL IN POST-THORACOTOMY PATIENTS

1986 • 3 citations

Reply

1986 • 2 citations

CONTINUOUS HYPOPHARYNGEAL PH DURING MASK ANESTHESIA

1986 • 2 citations

Surgery Effect of prophylactic epidural morphine or bupivacaine on postoperative pain after upper abdominal surgery

1983 • 1 citations