Warfarin—stereochemical aspects of its metabolism by rat liver microsomes

Statistical estimations in enzyme kinetics

1961 • 3,586 citations

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Microsomes and Drug Oxidations

1970 • 463 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

Fundamentals of Drug Metabolism and Drug Disposition

1973 • 270 citations

Existence and Separation of Three Forms of Cytochrome P-450 from Rat Liver Microsomes

1973 • 221 citations

Multiplicity of cytochrome P450 hemoproteins in rat liver microsomes

1974 • 200 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 178 citations

Studies on the 4-Hydroxycoumarins. XVII.^1a The Resolution and Absolute Configuration of Warfarin^1b

1961 • 153 citations

Approximate Significance Levels of the Behrens-Fisher Test

1964 • 145 citations

Gel electrophoresis of partially purified cytochromes P450 from liver microsomes of variously-treated rats

1973 • 136 citations

Prostaglandin Metabolism

1974 • 123 citations

Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man

1973 • 109 citations

Reductase for Aromatic Aldehydes and Ketones

1968 • 105 citations

Monooxygenase activity in Cunninghamella bainieri: Evidence for a fungal system similar to liver microsomes

1973 • 103 citations

Arene oxides as intermediates in the oxidative metabolism of aromatic compounds. Isomerization of methyl-substituted arene oxides

1972 • 102 citations

4-Hydroxycoumarins. Synthesis of the metabolites and some other derivatives of warfarin

1971 • 89 citations

Mass spectral analysis in the identification of human metabolites of warfarin

1970 • 83 citations

A comparison of the isomers of warfarin

1966 • 79 citations

Metabolism of chlorobenzene with hepatic microsomes and solubilized cytochrome P-450 systems

1975 • 69 citations

Absolute configurations of the four warfarin alcohols

1972 • 69 citations

Mechanism of the aromatization of arene oxides

1972 • 64 citations

The plasma half lives and the pharmacological effect of the enantiomers of warfarin in rats

1972 • 60 citations

The nature of the metabolites of acetohexamide in the rat and in the human.

1965 • 60 citations

Reduction of Ketones in Liver Cytosol

1971 • 56 citations

Pharmacokinetics of the warfarin enantiomers in rats

1974 • 54 citations

The metabolism of 4-C14-warfarin sodium by the rat.

1970 • 52 citations

Some problems in Michaelis-Menten kinetic analysis of benzpyrene hydroxylase in hepatic microsomes from polycyclic hydrocarbon-pretreated animals

1972 • 48 citations

Solvolytic Chemistry of 1,4-Dimethylbenzene Oxide. A New and Novel Mechanism for the NIH Shift

1972 • 41 citations

Effect of storage of frozen liver microsomal preparations on the hydroxylation of testosterone and pentobarbital and the N-demethylation of ethylmorphine

1969 • 38 citations

Differentiation between the concerted and stepwise mechanisms for aromatization (NIH-shift) of arene epoxides

1972 • 38 citations

The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique

1975 • 36 citations

The occurrence of multiple forms of cytochrome P-450 in hepatic microsomes from untreated rats and mice

1975 • 33 citations

Metabolism in vitro of warfarin by enzymic and nonenzymic systems

1968 • 29 citations

The plasma half-lives of the enantiomers of warfarin in warfarin-resistant and warfarin-susceptible rats

1972 • 28 citations

Bunolol Metabolism by Cell-Free Preparations of Human Liver: Biosynthesis of Dihydrobunolol

1972 • 28 citations

Effect of phenobarbital treatment on the stereochemistry of the in vitro metabolism of ethylbenzene

1973 • 23 citations

Dependence of Km and Vmax on substrate concentration for rat hepatic microsomal ethylmorphine N-demethylase

1973 • 22 citations

Studies of the microsomal drug metabolism system in warfarin-resistant and -susceptible rats

1975 • 17 citations

Warfarin metabolism in the guinea pig. I. Pharmacological studies.

1973 • 16 citations

Aromatization of 4-carboxybenzene oxide

1974 • 9 citations

.beta.-Chloroethylamines related to mescaline

1973 • 3 citations