Targeting high mobility group box 1 as a late-acting mediator of inflammation

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.

1992 • 1,488 citations

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

2000 • 1,385 citations

The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway

2002 • 890 citations

A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids

1973 • 757 citations

High-Mobility-Group Chromosomal Proteins: Architectural Components That Facilitate Chromatin Function

1996 • 752 citations

Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation

2000 • 687 citations

Receptor for Advanced Glycation End Products (RAGE)-mediated Neurite Outgrowth and Activation of NF-κB Require the Cytoplasmic Domain of the Receptor but Different Downstream Signaling Pathways

1999 • 621 citations

Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

1989 • 596 citations

Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

2002 • 589 citations

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

1999 • 523 citations

HMGB1 as a Late Mediator of Lethal Systemic Inflammation

2001 • 481 citations

The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

2001 • 454 citations

NEW EMBO MEMBERS' REVIEW: The double life of HMGB1 chromatin protein: architectural factor and extracellular signal

2001 • 429 citations

Revised nomenclature for high mobility group (HMG) chromosomal proteins

2001 • 369 citations

HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice

2002 • 315 citations

Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes

1999 • 294 citations

High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

2002 • 287 citations

Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation.

1993 • 218 citations

Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons.

1987 • 213 citations

Ringer’s ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats

2001 • 210 citations

Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock

2002 • 168 citations

HMGB-1, A DNA-BINDING PROTEIN WITH CYTOKINE ACTIVITY, INDUCES BRAIN TNF AND IL-6 PRODUCTION, AND MEDIATES ANOREXIA AND TASTE AVERSION

2002 • 149 citations

HMG-1 REDISCOVERED AS A CYTOKINE

2001 • 148 citations

Resuscitation from Hemorrhagic Shock with Ringer's Ethyl Pyruvate Solution Improves Survival And Ameliorates Intestinal Mucosal Hyperpermeability in Rats

2002 • 143 citations

Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin.

1991 • 142 citations

N‐Glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth

2002 • 131 citations

Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringerʼs ethyl pyruvate solution

2002 • 124 citations

Dual roles for HMGB1: DNA binding and cytokine

2001 • 121 citations

The Active Gene That Encodes Human High Mobility Group 1 Protein (HMG1) Contains Introns and Maps to Chromosome 13

1996 • 79 citations

Expression of P30, a protein with adhesive properties, in Schwann cells and neurons of the developing and regenerating peripheral nerve.

1991 • 62 citations

Melatonin Administration Following Hemorrhagic Shock Decreases Mortality from Subsequent Septic Challenge

1996 • 56 citations

Mapping of the Hmg1 gene and of seven related sequences in the mouse

1995 • 24 citations

Regulation of the expression of HMG1, a co-activator of the estrogen receptor.

2001 • 18 citations

THE HMG B BOX CONFERS CYTOKINE ACTIVITY AND SIGNALS VIA RAGE.

2001 • 3 citations