Inhibition of the growth of Plasmodium falciparum and Plasmodium berghei by the DNA polymerase inhibitor HPMPA

A novel selective broad-spectrum anti-DNA virus agent

1986 • 747 citations

Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin

1990 • 430 citations

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.

1990 • 417 citations

A third essential DNA polymerase in S. cerevisiae

1990 • 360 citations

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance.

1990 • 304 citations

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene.

1987 • 261 citations

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication

1988 • 218 citations

Characterization of a large form of DNA polymerase δ from HeLa cells that is insensitive to proliferating cell nuclear antigen

1989 • 141 citations

Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand

1983 • 126 citations

Revised nomenclature for eukaryotic DNA polymerases

1990 • 120 citations

Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.

1987 • 113 citations

Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication

1987 • 82 citations

An improved technique for the cultivation of Plasmodium falciparum in vitro without daily medium change

1985 • 78 citations

Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro

1987 • 66 citations

Recent Advances in the Search for Selective Antiviral Agents

1988 • 55 citations

Long-term in vitro cultures of Plasmodium berghei and preliminary observations on gametocytogenesis

1984 • 48 citations

Mechanism of inhibition of adenovirus DNA replication by the acyclic nucleoside triphosphate analogue (S)-HPMPApp: influence of the adenovirus DNA binding protein

1989 • 48 citations

Characterisation of cDNA clones for hypoxanthine–guanine phosphoribosyltransferase from the human malarial parasite,Plasmodium falciparum: comparisons to the mammalian gene and protein

1987 • 47 citations

Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues

1989 • 40 citations

Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis.

1987 • 23 citations

Cloning and expression in Escherichia coli of a hypoxanthine-guanine phosphoribosyltransferase-encoding cDNA from Plasmodium falciparum

1990 • 22 citations

Plasmodium falciparum: Properties of an α-like DNA polymerase, the key enzyme in DNA synthesis

1990 • 20 citations

Purification and characterization of DNA polymerases from Plasmodium berghei

1991 • 20 citations

Effect of polyamines on the activity of malarial α‐like DNA polymerase

1990 • 19 citations

ChemInform Abstract: Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues

1991 • 18 citations