Flash and smash: rapid freezing of muscle fibers activated by photolysis of caged ATP

The Mechanism of Muscular Contraction

1969 • 1,928 citations

Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.

1979 • 1,408 citations

Mechanism of adenosine triphosphate hydrolysis by actomyosin

1971 • 1,289 citations

The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigor

1967 • 1,089 citations

Three-dimensional reconstruction of F-actin, thin filaments and decorated thin filaments

1970 • 552 citations

Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay

1990 • 525 citations

Induced Changes in Orientation of the Cross-Bridges of Glycerinated Insect Flight Muscle

1965 • 471 citations

Molecular structure of F-actin and location of surface binding sites

1990 • 382 citations

X-ray evidence for conformational changes in the myosin filaments of vertebrate striated muscle

1975 • 283 citations

Structural changes during activation of frog muscle studied by time-resolved X-ray diffraction

1986 • 283 citations

Relaxation of rabbit psoas muscle fibres from rigor by photochemical generation of adenosine‐5'‐triphosphate.

1984 • 256 citations

Structural relationships of actin, myosin, and tropomyosin revealed by cryo-electron microscopy.

1987 • 248 citations

Orientation of spin labels attached to cross-bridges in contracting muscle fibres

1982 • 248 citations

Ultrastructure of insect flight muscle

1968 • 233 citations

Myosin head movements are synchronous with the elementary force-generating process in muscle

1992 • 203 citations

Kinetics of the Actomyosin ATPase in Muscle Fibers

1987 • 190 citations

A new model for the geometry of the binding of myosin crossbridges to muscle thin filaments

1981 • 152 citations

Control of sarcomere length in skinned muscle fibres of Rana temporaria during mechanical transients.

1984 • 149 citations

Initiation of active contraction by photogeneration of adenosine‐5'‐triphosphate in rabbit psoas muscle fibres.

1984 • 148 citations

The kinetics of magnesium adenosine triphosphate cleavage in skinned muscle fibres of the rabbit.

1984 • 136 citations

The structure of cytoplasm in directly frozen cultured cells. I. Filamentous meshworks and the cytoplasmic ground substance.

1984 • 126 citations

Tension transients during the rise of tetanic tension in frog muscle fibres.

1986 • 119 citations

Rigor crossbridge structure in tilted single filament layers and flared-X formations from insect flight muscle

1985 • 105 citations

Effects of AMPPNP on the orientation and rotational dynamics of spin-labeled muscle cross-bridges

1988 • 83 citations

Structure of the actin-myosin complex in the presence of ATP.

1985 • 81 citations

Actomyosin structure in contracting muscle detected by rapid freezing

1985 • 76 citations

Transients in orientation of a fluorescent cross-bridge probe following photolysis of caged nucleotides in skeletal muscle fibres

1992 • 63 citations

Direct visualization by electron microscopy of the weakly bound intermediates in the actomyosin adenosine triphosphatase cycle

1993 • 60 citations

Photolysis of a photolabile precursor of ATP (caged ATP) induces microsecond ratational motions of myosin heads bound to actin.

1989 • 57 citations

The Effects of Various Nucleotides on the Structure of Actin-Attached Myosin Subfragment-1 Studied by Quick-Freeze Deep-Etch Electron Microscopy1

1989 • 55 citations

Myosin heads have a broad orientational distribution during isometric muscle contraction: time-resolved EPR studies using caged ATP.

1990 • 53 citations

Three-Dimensional Image Analysis of the Complex of Thin Filaments and Myosin Molecules from Skeletal Muscle. IV.1 Reconstitution from Minimal- and High-Dose Images of the Actin-Tropomyosin-Myosin Subfragment-1 Complex2

1985 • 53 citations

Rotational dynamics of actin-bound myosin heads in active myofibrils

1993 • 51 citations

Electron microscopy of the actin-myosin head complex in the presence of ATP

1992 • 51 citations

Structure of the myosin filaments of relaxed and rigor vertebrate striated muscle studied by rapid freezing electron microscopy

1992 • 48 citations

New states of actomyosin.

1987 • 45 citations

A method for quick‐freezing live muscles at known instants during contraction with simultaneous recording of mechanical tension

1988 • 43 citations

The effect of the ATP analogue AMPPNP on the structure of crossbridges in vertebrate skeletal muscles: X-ray diffraction and mechanical studies

1984 • 41 citations

Three-dimensional image reconstruction of insect flight muscle. II. The rigor actin layer.

1989 • 41 citations

Time-resolved rotational dynamics of phosphorescent-labeled myosin heads in contracting muscle fibers

1990 • 40 citations

The structure and disposition of crossbridges in deep-etched fish muscle

1984 • 39 citations

Modeling rigor cross-bridge patterns in muscle I. Initial studies of the rigor lattice of insect flight muscle

1978 • 37 citations

Structure of the myosin crossbridge lattice in insect flight muscle

1983 • 36 citations

The structure of insect flight muscle in the presence of AMPPNP

1987 • 30 citations

Time‐resolved cryo‐electron microscopy of vitrified muscular components

1991 • 26 citations

Dynamic X-ray diffraction of skeletal muscle contraction: Structural change of actin filaments

1991 • 23 citations

Two-dimensional time resolved X-ray diffraction of muscle: Recent results

1991 • 22 citations

Dynamic X-ray diffraction measurements following photolytic relaxation and activation of skinned rabbit psoas fibres

1991 • 18 citations

Intensification of the first actin layer-line during contraction of frog skeletal muscle

1991 • 17 citations

Rigor crossbridges are double-headed in fast muscle from crayfish.

1987 • 15 citations

Conformations of crossbridges in contracting skeletal muscle

1991 • 6 citations