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Hepatic encephalopathy is associated with decreased cerebral oxygen metabolism and blood flow, not increased ammonia uptake

Data up to Jan 2025

Published2012
Citations70
References31

Total Citations Per Year

Abstract

References (31)

Co-Planar Stereotaxic Atlas of the Human Brain

1988 • 11,912 citations

Hepatic encephalopathy-Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998

2002 • 1,925 citations

The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia.

1979 • 406 citations

Brain α‐Ketoglutarate Dehydrogenase Complex: Kinetic Properties, Regional Distribution, and Effects of Inhibitors

1986 • 308 citations

Evidence of the Limitations of Water as a Freely Diffusible Tracer in Brain of the Rhesus Monkey

1974 • 277 citations

Hyponatremia Is a Risk Factor of Hepatic Encephalopathy in Patients With Cirrhosis: A Prospective Study With Time-Dependent Analysis

2009 • 228 citations

Selective increase of brain lactate synthesis in experimental acute liver failure: Results of a [1H-13C] nuclear magnetic resonance study

2003 • 193 citations

Signaling factors in the mechanism of ammonia neurotoxicity

2008 • 131 citations

A kinetic determination of ammonia in plasma

1974 • 128 citations

Brain metabolism of13N-ammonia during acute hepatic encephalopathy in cirrhosis measured by positron emission tomography

2005 • 121 citations

α-Ketoglutaramate: Increased Concentrations in the Cerebrospinal Fluid of Patients in Hepatic Coma

1974 • 117 citations

Successful use of bromocriptine in the treatment of chronic hepatic encephalopathy

1980 • 114 citations

Risk factors for hepatic encephalopathy in patients with cirrhosis and refractory ascites: relevance of serum sodium concentration

2010 • 107 citations

Low Cerebral Oxygen Consumption and Blood Flow in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy

2008 • 103 citations

Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence

2010 • 98 citations

Effects of Acute Hyperammonemia on Cerebral Amino Acid Metabolism and pHi In Vivo, Measured by 1H and 31P Nuclear Magnetic Resonance

1989 • 92 citations

Brain energy metabolism and mitochondrial dysfunction in acute and chronic hepatic encephalopathy

2011 • 91 citations

Correlations between magnetic resonance spectroscopy alterations and cerebral ammonia and glucose metabolism in cirrhotic patients with and without hepatic encephalopathy

2007 • 80 citations

Cerebral Blood Flow and Liver Function in Patients with Encephalopathy due to Acute and Chronic Liver Diseases

1989 • 75 citations

The metabolic role of isoleucine in detoxification of ammonia in cultured mouse neurons and astrocytes

2007 • 61 citations

Ammonia triggers exocytotic release of <scp>L</scp>‐glutamate from cultured rat astrocytes

2009 • 57 citations

Cerebral blood flow and metabolism in patients with chronic liver disease undergoing orthotopic liver transplantation

1998 • 53 citations

Cerebrospinal Fluid Lactate in Patients with Hepatic Encephalopathy

1987 • 46 citations

Reaction time and brain disease: relations to location, etiology and progression of cerebral dysfunction

2009 • 41 citations

A method to estimate dispersion in sampling catheters and to calculate dispersion-free blood time-activity curves

2008 • 35 citations

Metabolic fate of isoleucine in a rat model of hepatic encephalopathy and in cultured neural cells exposed to ammonia

2008 • 31 citations

Human 13N-ammonia PET studies: the importance of measuring 13N-ammonia metabolites in blood

2010 • 30 citations

Increase brain lactate in hepatic encephalopathy: Cause or consequence?

2010 • 21 citations

No oxygen delivery limitation in hepatic encephalopathy

2010 • 16 citations

Further Observations on the Lack of Effect of Isoniazid on the Blood Ammonia Concentration

1965 • 4 citations

Alteration of regional cerebral metabolism in patients with cirrhosis in positron emission tomography.

2001 • 3 citations

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