TNF-α and IFN-γ reverse IL-4 inhibition of lymphokine-activated killer cell function

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activity

1981 • 703 citations

In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2.

1985 • 600 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.

1988 • 280 citations

Recombinant interleukin 4 promotes the growth of human T cells.

1987 • 252 citations

Tumor necrosis factor-alpha enhances cytolytic activity of human natural killer cells.

1987 • 235 citations

B cell growth-promoting activity of recombinant human interleukin 4.

1987 • 211 citations

Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: effect of tumor necrosis factor alpha and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity.

1988 • 172 citations

Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

1988 • 168 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid alpha-interferon in the treatment of established murine hepatic metastases.

1988 • 153 citations

Mode of action of interferon-mediated modulation of natural killer cytotoxic activity: recruitment of pre-NK cells and enhanced kinetics of lysis.

1980 • 151 citations

Suppression of lymphokine-activated killer induction by neutrophils.

1988 • 150 citations

Analysis by a single cell cytotoxicity assay of natural killer (NK) cells frequencies among human large granular lymphocytes and of the effects of interferon on their activity.

1982 • 142 citations

Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).

1987 • 137 citations

Recombinant interferon-gamma induces interleukin 2 receptors on human peripheral blood monocytes.

1986 • 126 citations

The effects of IL-4 on human natural killer cells. A potent regulator of IL-2 activation and proliferation.

1988 • 118 citations

IL-2 stimulates the production of IL-1 alpha and IL-1 beta by human peripheral blood mononuclear cells.

1988 • 107 citations

IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes.

1989 • 106 citations

Tumor necrosis factor-alpha activation of the IL-2 receptor-alpha gene involves the induction of kappa B-specific DNA binding proteins.

1989 • 98 citations

Tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin) stimulate the production of granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, and IL-1 in vivo.

1988 • 97 citations

Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients.

1989 • 93 citations

Generation of lymphokine-activated killer cells: synergy between tumor necrosis factor and interleukin 2.

1988 • 93 citations

Synergistic effects of combination therapy with human recombinant interleukin-2 and tumor necrosis factor in murine tumor models.

1987 • 82 citations

Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.

1989 • 74 citations

Obligatory role of IFN-gamma in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxicity.

1988 • 70 citations

Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.

1987 • 69 citations

Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo.

1989 • 58 citations

Interferon-gamma enhances induction of lymphotoxin in recombinant interleukin 2-stimulated peripheral blood mononuclear cells.

1985 • 56 citations

IL-4 regulation of murine lymphokine-activated killer activity in vitro. Effects on the IL-2-induced expansion, cytotoxicity, and phenotype of lymphokine-activated killer effectors.

1989 • 49 citations

Successful therapy of natural killer-resistant pulmonary metastases by the synergism of gamma-interferon with tumor necrosis factor and interleukin-2 in mice.

1988 • 45 citations

Cytokine gene expression during the generation of human lymphokine-activated killer cells: early induction of interleukin 1 beta by interleukin 2.

1989 • 45 citations

The inhibitory effect of human interferon α on the generation of lymphokine-activated killer activity

1989 • 25 citations

Initial characterization of a lymphokine pathway for the immunologic induction of tumor necrosis factor-alpha release from human peripheral blood mononuclear cells.

1988 • 19 citations

Enhancement of suppressor T cell activity by injection of anti-IFN-gamma monoclonal antibody.

1988 • 12 citations