Endotoxin tolerance: In vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

1981 • 438 citations

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

1990 • 335 citations

Differential regulation of lipopolysaccharide‐induced interleukin 1 and tumor necrosis factor synthesis: effects of endogenous and exogenous glucocorticoids and the role of the pituitary‐adrenal axis

1989 • 328 citations

Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.

1986 • 267 citations

TOLERANCE TO BACTERIAL PYROGENS

1947 • 262 citations

Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice.

1990 • 216 citations

Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways.

1988 • 206 citations

Lipopolysaccharide Induces Hyporesponsiveness to Its Own Action in RAW 264.7 Cells

1989 • 162 citations

Differential cytokine induction by doses of lipopolysaccharide and monophosphoryl lipid A that result in equivalent early endotoxin tolerance

1990 • 123 citations

MODIFICATION OF HOST RESPONSES TO BACTERIAL ENDOTOXINS

1963 • 122 citations

Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression.

1989 • 116 citations

Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression

1991 • 107 citations

Glucocorticoid‐dependent and ‐independent mechanisms involved in lipopolysaccharide tolerance

1991 • 92 citations

Tolerance to the granulocyte-releasing and colony-stimulating factor elevating effects of endotoxin

1975 • 71 citations

Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.

1987 • 71 citations

Regulation of serum tumor necrosis factor in glucocorticoid-sensitive and -resistant rodent endotoxin shock models

1989 • 61 citations

Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance

1990 • 30 citations

Homologous and heterologous desensitization of proto‐oncogene cfos expression in murine peritoneal macrophages

1987 • 30 citations

Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance

1986 • 29 citations

Use of mice tolerant to lipopolysaccharide to demonstrate requirement of cooperation between macrophages and lymphocytes to generate lipopolysaccharide-induced colony-stimulating factor in vivo

1983 • 21 citations

Beneficial effects of endotoxins

1984 • 9 citations

Cited By (0)

Loading...