Furosemide pharmacokinetics and pharmacodynamics in health and disease—An update

Furosemide Absorption Altered in Decompensated Congestive Heart Failure

1985 • 220 citations

Evaluation of potential causes for the incomplete bioavailability of furosemide: Gastric first-pass metabolism

1983 • 173 citations

Bumetanide and furosemide in heart failure

1984 • 167 citations

Pharmacokinetics/pharmacodynamics of furosemide in man: A review

1979 • 154 citations

Furosemide in patients with heart failure: Shift in dose-response curves

1980 • 126 citations

Pharmacodynamic analysis of the furosemide-probenecid interaction in man

1979 • 126 citations

Renal tubular secretion and effects of furosemide

1980 • 123 citations

Plasma binding and disposition of furosemide in the nephrotic syndrome and in uremia

1978 • 123 citations

Pharmacokinetics of furosemide in man after intravenous and oral administration. Application of moment analysis

1984 • 121 citations

The time course of delivery of furosemide into urine: An independent determinant of overall response

1982 • 109 citations

Pharmacokinetics of orally administered furosemide

1974 • 108 citations

Acute tolerance to furosemide diuresis in humans. Pharmacokinetic-pharmacodynamic modeling.

1985 • 107 citations

Pharmacology of furosemide in the premature newborn infant

1980 • 105 citations

Pharmacokinetics of furosemide in normal subjects and functionally anephric patients

1974 • 100 citations

Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay.

1980 • 96 citations

Elimination of furosemide in healthy subjects and in those with renal failure

1977 • 89 citations

Pharmacokinetic-dynamic analysis of the indomethacin-furosemide interaction in man.

1980 • 89 citations

Clinical Pharmacokinetics of Frusemide

1979 • 86 citations

Determinants of response to frusemide in normal subjects.

1977 • 85 citations

Influence of hepatic cirrhosis and end-stage renal disease on pharmacokinetics and pharmacodynamics of furosemide

1981 • 85 citations

On the fate of furosemide in man

1975 • 80 citations

Diuresis with continuous infusion of furosemide after cardiac surgery

1983 • 79 citations

Pharmacokinetic disposition and protein binding of furosemide in newborn infants

1978 • 74 citations

Implications of intraindividual variability in bioavailability studies of furosemide

1984 • 73 citations

Distribution, elimination and effect of furosemide in normal subjects and in patients with heart failure

1977 • 72 citations

Effects of probenecid on furosemide kinetics and natriuresis in man

1977 • 71 citations

Influence of probenecid and spironolactone on furosemide kinetics and dynamics in man

1977 • 71 citations

Absorption and disposition of furosemide in congestive heart failure

1982 • 71 citations

Disposition and diuretic effect of furosemide in the nephrotic syndrome

1982 • 67 citations

Furosemide pharmacokinetics in very low birth weight infants

1988 • 65 citations

Furosemide kinetics and dynamics in patients with cirrhosis

1986 • 63 citations

Gastrointestinal sites of furosemide absorption in rats

1979 • 61 citations

The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog.

1978 • 59 citations

Bumetanide and furosemide

1983 • 59 citations

Response to furosemide in chronic renal insufficiency: Rationale for limited doses

1986 • 57 citations

The pharmacokinetics of frusemide are influenced by age.

1983 • 55 citations

Furosemide Disposition in Cirrhotic Patients

1981 • 53 citations

Pharmacokinetics of furosemide in anephric patients and in normal subjects

1978 • 51 citations

Pharmacokinetics and Pharmacodynamics of Lasix

1974 • 50 citations

Pharmacokinetics of furosemide in neonates

1982 • 48 citations

Influence of Sodium Balance on the Ability of Diuretics to Inhibit Tubular Reabsorption

1970 • 48 citations

Disposition and Absolute Bioavailability of Furosemide in Healthy Males

1982 • 47 citations

Kinetics and dynamics of furosemide and slow-acting furosemide

1982 • 46 citations

Pharmacokinetics of Furosemide in Patients with Congestive Heart Failure

1979 • 46 citations

Preliminary evaluation of furosemide–probenecid interaction in humans

1980 • 44 citations

Analysis of the effect of indomethacin on the response to furosemide in man: effect of dose of furosemide.

1979 • 44 citations

Furosemide kinetics and dynamics in aged patients

1983 • 43 citations

Furosemide 1-O-acyl glucuronide. In vitro biosynthesis and pH-dependent isomerization to beta-glucuronidase-resistant forms.

1985 • 42 citations

Altered furosemide pharmacokinetics in chronic alcoholic liver disease with ascites contributes to diuretic resistance

1987 • 42 citations

Plasma and urinary kinetics of furosemide in newborn infants

1983 • 40 citations

The influence of age on renal and extrarenal effects of frusemide.

1984 • 40 citations

Furosemide kinetics in patients with hepatic cirrhosis with ascites

1981 • 40 citations

Furosemide disposition in cirrhosis

1982 • 39 citations

Reduced bioavailability and effect of furosemide given with food

1986 • 38 citations

Delayed Tolerance to Furosemide Diuresis

1988 • 37 citations

Urinary Protein Binding, Kinetics, and Dynamics of Furosemide in Nephrotic Patients

1985 • 37 citations

Effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of furosemide

1986 • 36 citations

Metabolism and renal elimination of furosemide in the newborn infant

1982 • 35 citations

Influence of tablet dissolution on furosemide bioavailability: a bioequivalence study.

1987 • 34 citations

Effect of intravenous infusion time on the pharmacokinetics and pharmacodynamics of the same total dose of bumetanide

1993 • 33 citations

On the Mechanism of Acute Tolerance to Furosemide Diuresis

1988 • 31 citations

The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects

1982 • 29 citations

Inhibition of renal clearance of furosemide by pentopril, an angiotensin—converting enzyme inhibitor

1987 • 29 citations

Effects of the rate and composition of fluid replacement on the pharmacokinetics and pharmacodynamics of intravenous furosemide

1986 • 29 citations

Furosemide kinetics and dynamics after kidney transplant

1981 • 29 citations

Placental transfer of furosemide

1978 • 29 citations

Distribution, elimination and natriuretic effect of furosemide in patients with severe arterial hypertension

1978 • 28 citations

Comparative Bioavailability of Two Furosemide Formulations in Humans

1984 • 28 citations

The Use of HPLC to Elucidate the Metabolism and Urinary Excretion of Furosemide and its Metabolic Products

1981 • 28 citations

Frusemide Pharmacokinetics in Patients with Liver Disease

1980 • 27 citations

Pharmacokinetics of furosemide in patients with hepatic cirrhosis

1982 • 27 citations

Biotransformation of furosemide in patients with acute pulmonary edema.

1979 • 25 citations

Disposition of furosemide in functionally hepatectomized dogs.

1981 • 23 citations

Effect of dosage regimen on natriuretic response to furosemide

1975 • 22 citations

�ber die harnausscheidung von furosemid bei gesunden und kranken mit lebercirrhose

1970 • 21 citations

Kinetic disposition and diuretic effect of frusemide in acute pulmonary oedema.

1980 • 21 citations

Pharmacokinetics of Furosemide Urinary Elimination by Nephrotic Children

1983 • 21 citations

Biotransformation of furosemide in kidney transplant patients

1983 • 20 citations

The effect of ageing on the response to frusemide in normal subjects

1984 • 19 citations

Acute tolerance development to the diuretic effect of furosemide in the rat

1985 • 17 citations

Pharmacokinetics and pharmacodynamics of furosemide in geriatric patients

1986 • 17 citations

Pharmacodynamic and pharmacokinetic study of a slow-release formulation of furosemide in man.

1983 • 16 citations

Steady state absorption kinetics and pharmacodynamics of furosemide in congestive heart failure.

1987 • 16 citations

Bioavailability of seven furosemide tablets in man

1986 • 15 citations

Furosemide pharmacokinetics and pharmacodynamics in renal transplantation

1988 • 14 citations

Clinical pharmacokinetics and diuretic effect of furosemide in plain tablet and retard capsule with normal subjects and cirrhotic patients.

1983 • 14 citations

Clearance of furosemide by the gastrointestinal tract.

1986 • 13 citations

Determinants of the diuretic response to furosemide in infants with congestive heart failure

1982 • 13 citations

Hydralazine and furosemide kinetics

1982 • 13 citations

A comparison of the diuretic response to oral and intravenous furosemide in "duretic-resistant" patients.

1977 • 12 citations

Kinetics of furosemide in children with chronic renal failure undergoing regular haemodialysis

1982 • 12 citations

Pharmacokinetics of furosemide after three different single oral doses

1985 • 12 citations

Effects of phenobarbital and tobacco smoking on furosemide kinetics and dynamics in normal subjects

1983 • 11 citations

Clinical pharmacokinetics of furosemide in children with nephrotic syndrome.

1983 • 10 citations

Bioavailability and diuretic effect of furosemide during long-term treatment of chronic respiratory failure

1985 • 10 citations

The diuretic effect of furosemide in relation to its disposition in man.

1987 • 10 citations

Furosemide assays and disposition in healthy volunteers and renal transplant patients.

1983 • 9 citations

Pharmacokinetic and pharmacodynamic effects of furosemide in patients with impaired renal function.

1984 • 9 citations

A study on furosemide disposition in man.

1987 • 9 citations

Effect of cimetidine on the absorption and efficacy of orally administered furosemide.

1982 • 8 citations

Plasma protein binding of furosemide in the elderly

1987 • 8 citations

Urinary Elimination Kinetics and Diuretic Effect of Intravenous Furosemide in Nephrotic Children

1982 • 6 citations

The urinary excretion of frusemide and its metabolites by kidney transplant patients

1987 • 5 citations