Transgenic Mouse Expressing a Full‐length Hepatitis C Virus cDNA

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Genetic transformation of mouse embryos by microinjection of purified DNA.

1980 • 1,428 citations

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

1990 • 1,208 citations

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

1990 • 1,108 citations

Structure and organization of the hepatitis C virus genome isolated from human carriers

1991 • 970 citations

Expression and identification of hepatitis C virus polyprotein cleavage products

1993 • 890 citations

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets

1997 • 649 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

Hepatitis C virus core protein induces hepatic steatosis in transgenic mice.

1997 • 628 citations

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites

1993 • 601 citations

Long-term clinical and histopathological follow-up of chronic posttransfusion hepatitis

1991 • 542 citations

Demonstration of in Vitro Infection of Chimpanzee Hepatocytes with Hepatitis C Virus Using Strand-Specific RT/PCR

1994 • 308 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

Antibodies in Human Sera Specific to Hypervariable Region 1 of Hepatitis C Virus Can Block Viral Attachment

1995 • 227 citations

Sialadenitis histologically resembling Sjögren syndrome in mice transgenic for hepatitis C virus envelope genes

1997 • 227 citations

Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome

1993 • 219 citations

Expression and replication of hepatitis B virus genome in transgenic mice.

1989 • 196 citations

Hepatitis C virus: Detection of intracellular virus particles by electron microscop

1996 • 195 citations

The Hepatitis C Virus Encodes a Serine Protease Involved in Processing of the Putative Nonstructural Proteins from the Viral Polyprotein Precursor

1993 • 183 citations

Correlation between the infectivity of hepatitis C virus in vivo and its infectivity in vitro.

1993 • 160 citations

Hepatitis C virus core and E2 protein expression in transgenic mice

1997 • 138 citations

Transgenic expression of hepatitis C virus structural proteins in the mouse

1997 • 130 citations

Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells

1992 • 124 citations

Regulated processing of hepatitis C virus core protein is linked to subcellular localization

1997 • 124 citations

In vitro infection of peripheral blood mononuclear cells by hepatitis C virus

1995 • 123 citations

Detection of genomic and intermediate replicative strands of hepatitis C virus in liver tissue by in situ hybridization.

1993 • 114 citations

Susceptibility of Human T-Lymphotropic Virus Type I-Infected Cell Line MT-2 to Hepatitis C Virus Infection

1995 • 110 citations

Characterization of the nuclear localization signal and subcellular distribution of hepatitis C virus nonstructural protein NS5A

1996 • 99 citations

Expression of hepatitis C virus envelope proteins in transgenic mice

1995 • 93 citations

Transfection of HepG2 cells with infectious hepatitis C virus genome.

1997 • 81 citations

Replication of Hepatitis C Virus in Cultured Non‐neoplastic Human Hepatocytes

1996 • 73 citations

Inhibition of Hepatitis C Virus Replication by Antisense Oligonucleotide in Culture Cells

1995 • 62 citations

Hepatitis C Virus Viremia in SCID -> BNX Mouse Chimera

1995 • 62 citations

Molecular cloning and heterogeneity of the human hepatitis C virus (HCV) genome

1993 • 59 citations

Isolation and Characterization of the Complete Complementary and Genomic DNA Sequences of Human Serum Amyloid P Component1

1986 • 53 citations

Genetic analysis of the hepatitis C virus (HCV) genome from HCV-infected human T cells.

1997 • 52 citations

Introduction of Human γ1 Immunoglobulin Genes into Fertilized Mouse Eggs1

1984 • 50 citations

Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes

1997 • 47 citations

Long-Term Human T-Cell Culture System Supporting Hepatitis C Virus Replication

1996 • 42 citations

Selective transmission of hepatitis C virus in vivo and in vitro

1995 • 33 citations

Expression of the hepatitis c virus genome in rat liver after cationic liposome-mediated in vivo gene transfer*1

1995 • 32 citations

Localization of hepatitis C viral RNA and capsid protein in human liver

1993 • 30 citations

Developmental and Liver-Specific Expression Directed by the Serum Amyloid P Component Promoter in Transgenic Mice1

1992 • 29 citations

Ultrastructural observations of viral particles within hepatitis C virus-infected human B lymphoblastoid cell line

1997 • 26 citations

Characterization of T-cell tolerance to hepatitis B virus (HBV) antigen in transgenic mice.

1992 • 16 citations

Inactivation of hepatitis C virus cDNA transgene by hypermethylation in transgenic mice

1996 • 15 citations

Development of two types of hepatocellular carcinoma in transgenic mice carrying the SV40 large T-antigen gene

1991 • 15 citations

Correlation of Tissue‐specific Methylation with Gene Inactivity in Hepatitis B Virus Transgenic Mice

1990 • 9 citations

In vivo transfection of hepatitis C virus complementary DNA into rodent liver by asialoglycoprotein receptor mediated gene delivery

1995 • 8 citations

Expression of the hepatitis C virus genome in rat liver after cationic liposome-mediatedin vivo gene transfer

1995 • 6 citations