Human tumor extracellular pH as a function of blood glucose concentration

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Effect of local hyperthermia on blood flow and microenvironment: a review.

1984 • 610 citations

Are cancer cells acidic?

1991 • 576 citations

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

1981 • 339 citations

Differential response of normal and tumor microcirculation to hyperthermia.

1984 • 308 citations

Metabolic aspects of the role of hyperthermia im mammalian cell inactivation and their possible relevance to cancer treatment.

1974 • 305 citations

Modification of Cell Lethality at Elevated TemperaturesThe pH Effect¹

2012 • 267 citations

Modification of Cell Lethality at Elevated Temperatures The pH Effect

1977 • 243 citations

The effect of hyperthermia on vascular function, pH, and cell survival.

1980 • 208 citations

pH distribution in human tumors

1985 • 168 citations

pH STUDIES IN HUMAN MALIGNANT TUMOURS

1966 • 157 citations

RTOG quality assurance guidelines for clinical trials using hyperthermia

1990 • 135 citations

Tumor temperature distributions predict hyperthermia effect

1989 • 125 citations

Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

1982 • 120 citations

Hydralazine-enhanced selective heating of transmissible venereal tumor implants in dogs

1982 • 114 citations

Effects of Hyperglycemia and Hyperthermia on the pH, Glycolysis, and Respiration of the Yoshida Sarcoma In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1979 • 90 citations

Adaptation to low pH modifies thermal and thermo-chemical responses of mammalian cells

1986 • 87 citations

Effect of extracellular pH on thermotolerance and recovery of hyperthermic damage in vitro.

1979 • 79 citations

The effect of low pH on thermotolerance induction using fractionated 45 degrees C hyperthermia.

1981 • 71 citations

Hyperthermic Killing and Hyperthermic Radiosensitization in Chinese Hamster Ovary Cells: Effects of pH and Thermal Tolerance

1984 • 69 citations

Invited review: Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia

1988 • 67 citations

Influence of Extracellular pH on Intracellular pH and Cell Energy Status: Relationship to Hyperthermic Sensitivity

1988 • 66 citations

Modification of human tumor pH by elevation of blood glucose

1987 • 63 citations

Investigations on the pH of Malignant Tumours in Mice and Humans after the Administration of Glucose

1953 • 62 citations

Tumour pH in human mammary carcinoma

1982 • 61 citations

Tumor extracellular pH as a prognostic factor in thermoradiotherapy

1994 • 60 citations

Modification of intracellular pH and thermosensitivity.

1992 • 59 citations

Effect of hyperglycemia on the thermal response of murine normal and tumor tissues.

1983 • 57 citations

Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses.

1983 • 56 citations

Modification of Intracellular pH and Thermosensitivity

1992 • 47 citations

The Effect of Low pH on Thermotolerance Induction Using Fractionated 45°C Hyperthermia

1981 • 44 citations

Effect of hyperglycemia on thermochemotherapy of a spontaneous murine fibrosarcoma.

1983 • 43 citations

Effect of thermochemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration on a murine fibrosarcoma.

1985 • 41 citations

Effects of chronic pH 6.6 on growth, intracellular pH, and response to 42.0 degrees C hyperthermia of Chinese hamster ovary cells.

1988 • 37 citations

Enhancement of thermal damage to the microcirculation of ‘sandwich’ tumours by additional treatment

1981 • 35 citations

Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs

1992 • 35 citations

Comparison of the malignant potential of 10T 1/2 cells and transformants with their survival responses to hyperthermia and to amphotericin B1.

1980 • 32 citations

The Role of Intracellular pH and Its Variance in Low pH Sensitization of Killing by Hyperthermia

1990 • 31 citations

Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours

1990 • 25 citations

Temperature Gradients and Local Perfusion in a Mammary Carcinoma<xref ref-type="fn" rid="fn2">2</xref>

1982 • 25 citations

Influence of pH and Thermotolerance on the Enhancement of X-ray Induced Inactivation of Cultured Mammalian Cells by Hyperthermia

1983 • 23 citations

Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma

1983 • 23 citations

A METABOLIC CONTROL FOR THE ENHANCEMENT OF RADIATION RESPONSE

1970 • 23 citations

Insulin, Membranes, and Metabolism

1968 • 22 citations

Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia

1993 • 21 citations

Mechanisms of heat removal during local hyperthermia

1989 • 16 citations

7th International congress of radiation research

1982 • 12 citations

PROGNOSTIC VALUE OF TUMOR TISSUE pH FOR TUMOR RESPONSE TO HYPERTHERMIA

1992 • 6 citations

MRI AND MRS FOR PROGNOSTIC EVALUATION AND THERAPY MONITORING IN SOFT TISSUE SARCOMAS TREATED WITH HYPERTHERMIA AND RADIOTHERAPY

1992 • 4 citations

PROGNOSTIC VALUE OF TUMOR TISSUE pH FOR TUMOR RESPONSE TO HYPERTHERMIA

1991 • 3 citations