Splanchnic Blood Flow in Low-Flow States

Renin-angiotensin system: biochemistry and mechanisms of action.

1977 • 1,373 citations

Perioperative Plasma Volume Expansion Reduces the Incidence of Gut Mucosal Hypoperfusion During Cardiac Surgery

1995 • 652 citations

Effects of perfusion pressure on tissue perfusion in septic shock

2000 • 567 citations

Role of the Gut in Multiple Organ Failure: Bacterial Translocation and Permeability Changes

1996 • 561 citations

Systemic inflammatory response syndrome after cardiac operations

1996 • 526 citations

Evolving Concepts in the Pathogenesis of Postinjury Multiple Organ Failure

1995 • 525 citations

Postinjury Multiple Organ Failure

1996 • 490 citations

Gastric mucosal pH as a prognostic index of mortality in critically ill patients

1991 • 486 citations

Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)

1992 • 479 citations

Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response

1985 • 476 citations

Assessment of Splanchnic Oxygenation by Gastric Tonometry in Patients With Acute Circulatory Failure

1993 • 457 citations

The Effects of Balanced Versus Saline-Based Hetastarch and Crystalloid Solutions on Acid-Base and Electrolyte Status and Gastric Mucosal Perfusion in Elderly Surgical Patients

2001 • 454 citations

Intestinal blood flow

1980 • 426 citations

Hemorrhagic Shock Induces Bacterial Translocation from the Gut

1988 • 390 citations

Regional blood flow and oxygen transport in septic shock

1993 • 358 citations

Ischemic hepatitis: clinical presentation and pathogenesis

2000 • 347 citations

Acute Renal Failure Associated with Increased Intra-abdominal Pressure

1983 • 326 citations

Dopamine Neurotoxicity: Inhibition of Mitochondrial Respiration

1995 • 288 citations

Intestinal Permeability, Gastric Intramucosal pH, and Systemic Endotoxemia in Patients Undergoing Cardiopulmonary Bypass

1996 • 261 citations

The effects of dopamine and adrenaline infusions on acid-base balance and systemic haemodynamics in severe infection

1996 • 231 citations

Splanchnic and total body oxygen consumption differences in septic and injured patients.

1987 • 229 citations

THE MESENTERIC HEMODYNAMIC RESPONSE TO CIRCULATORY SHOCK: AN OVERVIEW

2001 • 218 citations

Repeated Administration of Vasopressin but Not Epinephrine Maintains Coronary Perfusion Pressure After Early and Late Administration During Prolonged Cardiopulmonary Resuscitation in Pigs

1999 • 192 citations

Effects of Hemorrhage on Regional Blood Flow Distribution in Dogs and Primates

1974 • 186 citations

Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin

1970 • 162 citations

Protection of the small intestine from nonocclusive mesenteric ischemic injury due to cardiogenic shock

1987 • 157 citations

Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery

1995 • 154 citations

Hemodynamic, metabolic, and hematologic effects of pulsatile cardiopulmonary bypass

1974 • 150 citations

Effect of Hemorrhage on the Cardiac Output and Distribution in the Rat

1960 • 146 citations

Quantitation of the hepatic arterial buffer response to graded changes in portal blood flow

1990 • 145 citations

The Effect of Cardiopulmonary Bypass on Intestinal and Pulmonary Endothelial Permeability

1995 • 141 citations

Effect of Vasopressin on Hemodynamic Variables, Organ Blood Flow, and Acid-Base Status in a Pig Model of Cardiopulmonary Resuscitation

1993 • 141 citations

Heterogeneous regional vascular responses to simulated transient hypovolemia in man

1994 • 135 citations

Early metabolic and splanchnic responses to enteral nutrition in postoperative cardiac surgery patients with circulatory compromise

2001 • 131 citations

Dynamic study of the distribution of microcirculatory blood flow in multiple splanchnic organs in septic shock

2000 • 126 citations

Effects of a Dobutamine-induced Increase in Splanchnic Blood Flow on Hepatic Metabolic Activity in Patients with Septic Shock

1997 • 126 citations

Hypoxic hepatitis in patients with cardiac failure: incidence in a coronary care unit and measurement of hepatic blood flow

1994 • 125 citations

Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock

1999 • 125 citations

Hepatic metabolic response to injury and sepsis

1995 • 123 citations

Effects of cardiopulmonary bypass on gut blood flow, oxygen utilization, and intramucosal pH

1994 • 113 citations

The 1995 Ciba-Geigy Award Lecture. Intrinsic regulation of hepatic blood flow

1996 • 105 citations

Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand

1995 • 105 citations

Pathogenesis of Nonocclusive Ischemic Colitis

1986 • 104 citations

Central and regional hemodynamics during acute hypovolemia and volume substitution in volunteers

1997 • 104 citations

Failure of Splanchnic Resuscitation in the Acutely Injured Trauma Patient Correlates With Multiple Organ System Failure and Length of Stay in the ICU

1998 • 103 citations

Dobutamine-induced dissociation between changes in splanchnic blood flow and gastric intramucosal pH after cardiac surgery

1995 • 100 citations

The 1995 Ciba-Geigy Award Lecture. Intrinsic regulation of hepatic blood flow

1996 • 98 citations

Effects of endothelin on regional blood flows in squirrel monkeys.

1989 • 95 citations

Effect of Cardiopulmonary Bypass Perfusion Protocols on Gut Tissue Oxygenation and Blood Flow

1997 • 93 citations

Determinants of intestinal barrier failure in critical illness

1996 • 93 citations

Regional blood flow and oxygen transport in patients with the low cardiac output syndrome after cardiac surgery

1993 • 91 citations

Comparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock.

1995 • 87 citations

MESENTERIC VASOCONSTRICTION IN RESPONSE TO HEMORRHAGIC SHOCK

2000 • 86 citations

Intestinal and Hemodynamic Impairment Following Mesenteric Ischemia/Reperfusion

2001 • 80 citations

Hepatic blood flow and splanchnic oxygen consumption measurements in clinical sepsis.

1990 • 79 citations

Effects of Dopamine on Systemic and Regional Blood Flow and Metabolism in Septic and Cardiac Surgery Patients

2002 • 76 citations

Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients

2001 • 74 citations

Effective Hepatic Blood Flow During Cardiopulmonary Bypass

1989 • 73 citations

Loss of Physiologic Hepatic Blood Flow Control (“Hepatic Arterial Buffer Response”) During CO2-Pneumoperitoneum in the Rat

2001 • 70 citations

Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock*

2002 • 69 citations

Splanchnic perfusion during hemodialysis: Evidence for marginal tissue perfusion

2001 • 67 citations

Role of nitric oxide in porcine liver circulation under normal and endotoxemic conditions

1995 • 67 citations

A Dobutamine Test Can Disclose Hepatosplanchnic Hypoperfusion in Septic Patients

1999 • 65 citations

Splanchnic and renal blood flow after cardiopulmonary resuscitation with epinephrine and vasopressin in pigs

1998 • 63 citations

Pathophysiology of hepatic ischemia in cardiogenic shock

1986 • 62 citations

Monitoring of tissue oxygenation in shock

1995 • 61 citations

Bacterial Translocation in Experimental Shock Is Dependent on the Strains in the Intestinal Flora

2000 • 60 citations

Sequential changes in the splanchnic circulation during continuous endotoxin infusion in sedated sheep: evidence for a selective increase of hepatic artery blood flow and loss of the hepatic arterial buffer response

1993 • 60 citations

The hepatic haemodynamic response to acute portal venous blood flow reductions in the dog

1983 • 59 citations

Splanchnic vasomotor and metabolic adjustments to hypoxia and exercise in humans

1984 • 56 citations

Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage

2000 • 55 citations

Effects of systemic arterial hypoperfusion on splanchnic hemodynamics and hepatic arterial buffer response in pigs

2001 • 52 citations

The role of angiotensin II in the development of peripheral vasoconstriction during open-heart surgery

1980 • 50 citations

The Fundamental Hemodynamic Mechanism Underlying Gastric “Stress Ulceration” in Cardiogenic Shock

1987 • 50 citations

Pressure-flow analysis of portal vein and hepatic artery interactions in porcine liver

1994 • 49 citations

Alternations in liver hemodynamics in an intact porcine model of endotoxin shock

1995 • 48 citations

Ischemically sensitive abdominal visceral afferents: response to cyclooxygenase blockade

1991 • 48 citations

SYMPATHETIC AND RENIN-ANGIOTENSIN ACTIVATION DURING GRADED HYPOVOLEMIA IN PIGS

1997 • 45 citations

Regional blood flow during cardiopulmonary resuscitation in dogs

1984 • 43 citations

ENALAPRILAT IMPROVES GUT PERFUSION IN CRITICALLY INJURED PATIENTS

1998 • 43 citations

Systemic and regional pCO2 gradients as markers of intestinal ischaemia

1998 • 42 citations

Hepato-splanchnic metabolic effects of the stable prostacyclin analogue iloprost in patients with septic shock

2001 • 42 citations

PLASMA ACTIVATION DURING SPLANCHNIC ARTERIAL OCCLUSION SHOCK

2000 • 41 citations

Assessment of the adequacy of systemic and regional perfusion after cardiac surgery

2000 • 40 citations

Pre-operative tonometry is predictive for mortality and morbidity in high-risk surgical patients

2000 • 39 citations

Impairment of Hepatosplanchnic Oxygenation and Increase of Serum Hyaluronate During Normothermic and Mild Hypothermic Cardiopulmonary Bypass

2002 • 37 citations

Impairment of Hepatosplanchnic Oxygenation and Increase of Serum Hyaluronate During Normothermic and Mild Hypothermic Cardiopulmonary Bypass

2002 • 36 citations

Effects of cardiac tamponade on colonic hemodynamics and oxygen uptake

1983 • 35 citations

Preserved arterial flow secures hepatic oxygenation during haemorrhage in the pig

1999 • 34 citations

The Effect of Increasing Blood Pressure with Dopamine on Systemic, Splanchnic, and Lower Extremity Hemodynamics in Patients with Acute Liver Failure

1999 • 33 citations

Effects of hemodilution on splanchnic perfusion and hepatorenal function. I. Splanchnic perfusion.

1997 • 31 citations

Evidence of cardiac inflammation after open heart operations

1994 • 31 citations

Maintenance of hepatic arterial blood flow during hemorrhage is mediated by adenosine

1989 • 31 citations

Splanchnic Vasoregulation During Mesenteric Ischemia and Reperfusion in Pigs

2002 • 30 citations

Effects of hemodilution on splanchnic perfusion and hepatorenal function. II. Renal perfusion and hepatorenal function.

1997 • 29 citations

Cardiovascular reflex responses to ischemia during occlusion of celiac and/or superior mesenteric arteries

1997 • 27 citations

HEMODYNAMIC PATHOGENESIS OF ISCHEMIC HEPATIC INJURY FOLLOWING CARDIOGENIC SHOCK/RESUSCITATION

2000 • 26 citations

Do fluid administration and reduction in norepinephrine dose improve global and splanchnic haemodynamics?

2000 • 25 citations

Intraoperative and Early Postoperative Gastric Intramucosal pH Predicts Morbidity and Mortality after Major Abdominal Surgery

2001 • 25 citations

Hepato-splanchnic Blood Flow and Oxygen Extraction Capabilities during Experimental Tamponade: Effects of Endotoxin

1999 • 25 citations

Endothelin-1 blockade corrects mesenteric hypoperfusion in a porcine low cardiac output model

2001 • 23 citations

Effects of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery

1999 • 23 citations

Cardiovascular dysfunction in sepsis and septic shock

2000 • 22 citations

The Effects of Vasoactive Drugs on Hepatic Blood Flow Changes Induced by CO2 Laparoscopy: An Animal Study

2001 • 20 citations

Dopamine-1 receptor stimulation attenuates the vasoconstrictive response to gut ischemia

2001 • 20 citations

Impact of the hepatic arterial buffer response on splanchnic vascular responses to intravenous adenosine, isoproterenol, and glucagon

1988 • 19 citations

Splanchnic haemodynamics after intravenous terlipressin in anaesthetised healthy pigs

1999 • 19 citations

Beta-adrenergic-dependent and -independent actions of naloxone on perfusion during endotoxin shock.

1993 • 14 citations

The effect of a pre‐operative infusion of Ringer's solution on splanchnic perfusion in patients undergoing coronary artery bypass grafting

2002 • 13 citations

Hemodynamic effects of a combination of prazosin and terlipressin in patients with viral cirrhosis

2001 • 12 citations

Hemodynamic Effects of A Combination of Prazosin and Terlipressin in Patients With Viral Cirrhosis

2001 • 11 citations

Liver hemodynamics during portal venous endotoxemia in swine.

1993 • 11 citations

Cardiovascular reflexes during abdominal ischemia in cats

1994 • 11 citations

7 DIRECT INJURY OF THE LUNG

1995 • 10 citations

Angiotensin II mesenteric and renal vasoregulation: Dissimilar modulatory effects with nitroprusside

2000 • 6 citations