The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)–like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines

2008 • 3,127 citations

Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia

1999 • 2,674 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

2007 • 1,060 citations

Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia

2008 • 588 citations

Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations

2006 • 507 citations

Diagnostic criteria for monoclonal B‐cell lymphocytosis

2005 • 395 citations

Monoclonal B lymphocytes with the characteristics of “indolent” chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts

2002 • 341 citations

Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis

2007 • 328 citations

IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis

2004 • 307 citations

Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy

2001 • 270 citations

Association between the Gene Encoding 5-Lipoxygenase–Activating Protein and Stroke Replicated in a Scottish Population

2005 • 237 citations

Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly

2003 • 235 citations

Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus–associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor–producing cells that occur mainly in type II cryoglobulinemia

2000 • 227 citations

Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion

2002 • 227 citations

Effect of age on humoral immunity, selection of the B‐cell repertoire and B‐cell development

1997 • 186 citations

Novel Case-Control Test in a Founder Population Identifies P-Selectin as an Atopy-Susceptibility Locus

2003 • 158 citations

Isolates and their potential use in complex gene mapping efforts

2004 • 126 citations

Software for Constructing and Verifying Pedigrees within Large Genealogies and an Application to the Old Order Amish of Lancaster County

1998 • 108 citations

The B‐cell biology of aging

1997 • 95 citations

Benign monoclonal B cell lymphocytosis--a benign variant of CLL: clinical, immunologic, phenotypic, and cytogenetic studies in 20 patients

1984 • 87 citations

Evidence for the overexpression of the VH4-34 (VH4.21) Ig gene segment in the normal adult human peripheral blood B cell repertoire.

1995 • 75 citations

Prevalence and natural history of monoclonal and polyclonal B‐cell lymphocytosis in a residential adult population

2007 • 73 citations

Monoclonal B‐cell lymphocytosis in blood donors

2007 • 65 citations

Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ‐line gene usage

1997 • 63 citations

MBL or CLL: Which classification best categorizes the clinical course of patients with an absolute lymphocyte count ≥5×109L−1 but a B-cell lymphocyte count <5×109L−1?

2008 • 42 citations

Clonal cell surface structures related to differentiation, activation and homing in B‐cell chronic lymphocytic leukemia and monoclonal lymphocytosis of undetermined significance

1989 • 35 citations

CD5-positive B cells in healthy elderly humans are a polyclonal B cell population

2000 • 33 citations

Monoclonal B‐cell lymphocytosis as a biomarker in environmental health studies

2007 • 30 citations

Variation of hemoglobin levels in normal Italian populations from genetic isolates

2008 • 30 citations

Benign monoclonal B cell lymphocytosis--a benign variant of CLL: clinical, immunologic, phenotypic, and cytogenetic studies in 20 patients

1984 • 6 citations