Anabolic or Catabolic Responses of MC3T3-E1 Osteoblastic Cells to Parathyroid Hormone Depend on Time and Duration of Treatment

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

1992 • 1,009 citations

Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development

1992 • 949 citations

Anabolic Actions of Parathyroid Hormone on Bone*

1993 • 721 citations

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells.

1995 • 580 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

Establishment of a clonal osteogenic cell line from newborn mouse calvaria

1981 • 501 citations

Rapidly Forming Apatitic Mineral in an Osteoblastic Cell Line (UMR 106—01 BSP)

1995 • 429 citations

STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM

1929 • 384 citations

Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone

1992 • 364 citations

Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*

1989 • 337 citations

Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.

1997 • 335 citations

Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats.

1993 • 276 citations

ON THE STIMULATION OF NEW BONE-FORMATION WITH PARATHYROID EXTRACT AND IRRADIATED ERGOSTEROL

1932 • 263 citations

Increased bone formation by intermittent parathyroid hormone administration is due to the stimulation of proliferation and differentiation of osteoprogenitor cells in bone marrow

1994 • 248 citations

Human Parathyroid Hormone-(l–34) Increases Bone Mass in Ovariectomized and Orchidectomized Rats*

1988 • 243 citations

Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells.

1994 • 240 citations

Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.

1981 • 233 citations

Connexin43 mediates direct intercellular communication in human osteoblastic cell networks.

1993 • 227 citations

ANABOLIC EFFECT OF LOW DOSES OF A FRAGMENT OF HUMAN PARATHYROID HORMONE ON THE SKELETON IN POSTMENOPAUSAL OSTEOPOROSIS

1976 • 209 citations

1,25-Dihydroxyvitamin D3 stimulates the alkaline phosphatase activity of osteoblast-like cells.

1981 • 195 citations

Parathyroid hormone induces sequential c-fos expression in bone cells in vivo: in situ localization of its receptor and c-fos messenger ribonucleic acids

1994 • 183 citations

The Anabolic Effects of Human Parathyroid Hormone (hPTH) on Rat Vertebral Body Mass Are also Reflected in the Quality of Bone, Assessed by Biomechanical Testing: A Comparison Study between hPTH-(1–34) and hPTH-(1–84)*

1991 • 179 citations

Cell-to-cell communication in osteoblastic networks: Cell line–dependent hormonal regulation of gap junction function

1995 • 170 citations

Glucocorticoid Regulation of Alkaline Phosphatase in the Osteoblastic Osteosarcoma Cell Line ROS 17/2.8*

1985 • 162 citations

Parathyroid Hormone Stimulates the Proliferation of Cells Derived from Human Bone*

1986 • 161 citations

Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages

1996 • 138 citations

The incidence and size of gap junctions between the bone cells in rat calvaria

1993 • 127 citations

Signal transduction pathways mediating parathyroid hormone regulation of osteoblastic gene expression

1994 • 126 citations

Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells.

1992 • 124 citations

Contrasting effects of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis

1992 • 120 citations

Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats.

1995 • 117 citations

Gap Junctional Intercellular Communication Contributes to Hormonal Responsiveness in Osteoblastic Networks

1996 • 112 citations

Characterization of gap junctions between osteoblast-like cells in culture

1992 • 112 citations

Characterization of the major parathyroid hormone target cell in the endosteal metaphysis of rat long bones

1990 • 112 citations

Identification of hydroxyapatite crystals in synovial fluid

1979 • 102 citations

A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats

1995 • 99 citations

Parathyroid hormone monotherapy and cotherapy with antiresorptive agents restore vertebral bone mass and strength in aged ovariectomized rats

1995 • 90 citations

PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis

1996 • 81 citations

Tissue-Specific Transcription Start Sites and Alternative Splicing of the Parathyroid Hormone (PTH)/PTH-Related Peptide (PTHrP) Receptor Gene: A New PTH/PTHrP Receptor Splice Variant that Lacks the Signal Peptide*

1997 • 77 citations

Fas/APO-1(CD95)-Induced Apoptosis of Primary Hepatocytes Is Inhibited by cAMP

1997 • 63 citations

Parathyroid Hormone Up-Regulation of Connexin 43 Gene Expression in Osteoblasts Depends on Cell Phenotype

1997 • 62 citations

Hormonal regulation of intercellular communication: parathyroid hormone increases connexin 43 gene expression and gap-junctional communication in osteoblastic cells

1992 • 58 citations

Gap junction proteins exhibit early and specific expression during intramembranous bone formation in the developing chick mandible

1994 • 57 citations

Isolation and characterization of gap junctions in the osteoblastic MC3T3-E1 cell line

1994 • 55 citations

Parathyroid Hormone Enhances Early and Suppresses Late Stages of Osteogenic and Chondrogenic Development in a BMP-Dependent Mesenchymal Differentiation System (C3H10T½)

1997 • 52 citations

Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo

1996 • 50 citations

Temporal Changes of mRNA Expression of Matrix Proteins and Parathyroid Hormone and Parathyroid Hormone–Related Protein (PTH/PTHrP) Receptor in Bone Development

1997 • 48 citations

Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation

1996 • 42 citations

Expression of the parathyroid hormone receptor and correlation with other osteoblastic parameters in fetal rat osteoblasts

1996 • 39 citations

Phenotypic Heterogeneity of Osteoblast-like MC3T3-E1 Cells: Changes of Bradykinin-Induced Prostaglandin E2 Production During Osteoblast Maturation

1997 • 36 citations

Human parathyroid peptide treatment of vertebral osteoporosis

1993 • 36 citations