Clinical Pharmacokinetics and Pharmacodynamics of Cholinesterase Inhibitors

“Mini-mental state”

1975 • 82,784 citations

Normative data on a battery of neuropsychological tests in the Han Chinese population

2010 • 20,181 citations

Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review

2013 • 20,010 citations

Older Adults' Reasons for Using Technology while Aging in Place

2015 • 19,091 citations

Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly

2014 • 18,386 citations

The Neuropsychiatric Inventory

1994 • 7,026 citations

A new rating scale for Alzheimer's disease

1984 • 3,948 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

Statins and the risk of dementia

2000 • 1,741 citations

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease

1998 • 1,575 citations

Practice guideline for the treatment of patients with schizophrenia. American Psychiatric Association

1997 • 1,357 citations

Patterns of Brain Activation in People at Risk for Alzheimer's Disease

2000 • 1,282 citations

Physician's desk reference

1987 • 1,036 citations

A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease

1994 • 953 citations

Diagnosis and Treatment of Alzheimer Disease and Related Disorders

1997 • 925 citations

A 5-month, randomized, placebo-controlled trial of galantamine in AD

2000 • 911 citations

Galantamine in AD

2000 • 864 citations

Donepezil Improves Cognition and Global Function in Alzheimer Disease<subtitle>A 15-Week, Double-blind, Placebo-Controlled Study</subtitle>

1998 • 753 citations

Hepatotoxic Effects of Tacrine Administration in Patients With Alzheimer's Disease

1994 • 736 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Validity and Reliability of the Alzheimerʼs Disease Cooperative Study-Clinical Global Impression of Change

1997 • 620 citations

The Effects of Donepezil in Alzheimer’s Disease – Results from a Multinational Trial<sup>1</sup>

1999 • 581 citations

A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study Group

1992 • 539 citations

Commentary: Another piece of the Alzheimer's jigsaw

1999 • 502 citations

A randomized trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderately severe Alzheimer's disease

1998 • 473 citations

Molecular Basis of the Neurodegenerative Disorders

1999 • 393 citations

Cholinesterase Inhibitors: A New Class of Psychotropic Compounds

2000 • 384 citations

A Controlled Trial of Tacrine in Alzheimer's Disease

1992 • 382 citations

Oxidative injury in diseases of the central nervous system: focus on alzheimer’s disease

2000 • 378 citations

Cholinesterase Inhibitors in the Treatment of Alzheimer??s Disease

1998 • 369 citations

Galantamine

2000 • 348 citations

Acetylcholinesterase inhibitors in Alzheimer’s disease

1999 • 328 citations

Validity and Reliability of the Alzheimer’s Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC)

1997 • 310 citations

Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer’s disease

2001 • 299 citations

Butyrylcholinesterase in the life cycle of amyloid plaques

1997 • 294 citations

Rivastigmine, a New‐Generation Cholinesterase Inhibitor for the Treatment of Alzheimer's Disease

2000 • 213 citations

Effect of Tacrine on Behavioral Symptoms in Alzheimer's Disease: An Open-Label Study

1996 • 209 citations

Invited Review Cholinesterase inhibitors for Alzheimer’s disease therapy: from tacrine to future applications

1998 • 202 citations

Tacrine: First Drug Approved for Alzheimer's Disease

1994 • 187 citations

Measurement of quality-of-life changes in patients with Alzheimer's disease.

1989 • 186 citations

Cholinesterase Inhibitors: A Therapeutic Strategy for Alzheimer Disease

1999 • 183 citations

Rivastigmine

1998 • 179 citations

Donepezil

2000 • 175 citations

Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses

1998 • 166 citations

Tacrine

1994 • 139 citations

Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses

1998 • 133 citations

Donepezil Use in Alzheimer Disease

1998 • 126 citations

Combined glutathione-S -transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity

2000 • 121 citations

Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease

2009 • 120 citations

Pharmacodynamic-Tolerability Relationships of Cholinesterase Inhibitors for Alzheimer??s Disease

2001 • 116 citations

Cognitive Enhancement Therapy for Alzheimerʼs Disease

1997 • 113 citations

Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease

2001 • 111 citations

Metabolism and elimination of ¹⁴C‐donepezil in healthy volunteers: a single‐dose study

1998 • 110 citations

Donepezil: an anticholinesterase inhibitor for Alzheimer’s disease

1997 • 104 citations

Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition

1991 • 91 citations

Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications

2000 • 91 citations

Comparison of the Pharmacokinetics of E2020, A New Compound for Alzheimer's Disease, in Healthy Young and Elderly Subjects

1993 • 87 citations

Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses

1998 • 76 citations

Safety/tolerability trial of SDZ ENA 713 in patients with probable Alzheimer's disease

1996 • 74 citations

Recent Developments in the Drug Treatment of Alzheimer??s Disease

1999 • 74 citations

Preferential Cerebrospinal Fluid Acetylcholinesterase Inhibition by Rivastigmine in Humans

1999 • 72 citations

Do Cholinesterase Inhibitors Have Disease-Modifying Effects in Alzheimer??s Disease?

2001 • 72 citations

Effects of Donepezil on Emotional/Behavioral Symptoms in Alzheimer's Disease Patients

2000 • 71 citations

Serum concentrations of tacrine hydrochloride predict its adverse effects in Alzheimer's disease

1993 • 65 citations

Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association [published erratum appears in Am J Psychiatry 1997 Aug;154(8):1180]

1997 • 64 citations

Clinical Pharmacokinetics of Tacrine

1995 • 57 citations

Preclinical Pharmacology of Metrifonate

1998 • 56 citations

Pharmacokinetics of tacrine hydrochloride in Alzheimer's disease

1989 • 56 citations

Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses

1998 • 56 citations

Clinical pharmacokinetics of intravenous and oral 9-amino-1,2,3,4-tetrahydroacridine, tacrine

1990 • 55 citations

Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans*

1997 • 54 citations

Pharmacologic treatment of cognition in Alzheimer's dementia

1998 • 53 citations

An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function

1998 • 50 citations

Evaluation of HP 029 (Velnacrine Maleate) in Alzheimer's Diseasea

1991 • 50 citations

The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6

1999 • 49 citations

CNS Nicotinic Receptors

1994 • 48 citations

Cerebral Pharmacodynamics of Physostigmine in Alzheimer's Disease Investigated Using Single-Photon Computerised Tomography

1991 • 48 citations

The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin

1998 • 47 citations

Pharmacokinetics of Galanthamine Hydrobromide after Single Subcutaneous and Oral Dosage in Humans

1989 • 47 citations

Glutathione S‐transferase mu genotype (GSTM1*0) in Alzheimer's patients with tacrine transaminitis.

1995 • 46 citations

Clinical Pharmacokinetics of Drugs for Alzheimer's Disease

1995 • 43 citations

An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function

1998 • 39 citations

Fulminant Chemical Hepatitis Possibly Associated with Donepezil and Sertraline Therapy

2000 • 38 citations

Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple‐dose administration in healthy volunteers

1998 • 37 citations

Concurrent administration of donepezil HCl and digoxin: assessment of pharmacokinetic changes

1998 • 36 citations

Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

1998 • 34 citations

Cholinesterase Inhibitors for the Treatment of Alzheimer??s Disease in the Elderly

2000 • 34 citations

Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy

1999 • 33 citations

The use of nitrates, calcium channel blockers and ACE inhibitors in primary care in the Northern Region: a pharmacoepidemiological study.

1994 • 30 citations

Steady-state pharmacokinetics of tacrine in patients with Alzheimer's disease.

1990 • 29 citations

Differential effects of GABA on peripheral and central type benzodiazepine binding sites in brain

1982 • 27 citations

Metrifonate: Overview of Safety and Efficacy

1998 • 27 citations

Maximum Tolerated Dose and Pharmacodynamics of Eptastigmine in Elderly Healthy Volunteers

1998 • 20 citations

Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease

1998 • 20 citations

Pharmacokinetic studies of cholinesterase inhibitors

2009 • 16 citations

Inhibition of tacrine oral clearance by cimetidine

1996 • 15 citations

SPECT Brain Imaging in Alzheimer??s Disease during Treatment with Oral Tetrahydroaminoacridine and Lecithin

1992 • 12 citations

Penetration of Tacrine Into Cerebrospinal Fluid in Patients With Alzheimer's Disease

1998 • 9 citations

Is the Use of Chemotherapy Justified in Non-Small-Cell Lung Cancer?

1994 • 7 citations

Statistical Issues in the Design and Analysis of Clinical Trials in Alzheimer's Disease

1996 • 2 citations

Deleted Work

1955 • 0 citations