Modeling and active site refinement for G protein-coupled receptors: application to the β-2 adrenergic receptor

The Protein Data Bank

2000 • 35,287 citations

Scalable molecular dynamics with NAMD

2005 • 16,463 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Protein secondary structure prediction based on position-specific scoring matrices 1 1Edited by G. Von Heijne

1999 • 5,382 citations

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

2003 • 3,670 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects

2005 • 1,799 citations

GPCRdb: an information system for G protein-coupled receptors

2015 • 1,057 citations

Improving the prediction of protein secondary structure in three and eight classes using recurrent neural networks and profiles

2002 • 753 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

GCRDb: a G-protein-coupled receptor database.

1994 • 517 citations

Modeling of G-protein-coupled receptors: application to dopamine, adrenaline, serotonin, acetylcholine, and mammalian opsin receptors

1992 • 415 citations

Three-dimensional models of neurotransmitter G-binding protein-coupled receptors.

1991 • 330 citations

Protein‐based virtual screening of chemical databases. II. Are homology models of g‐protein coupled receptors suitable targets?

2002 • 295 citations

The G-Protein Linked Receptor Facts Book

1994 • 292 citations

Prediction of structure and function of G protein-coupled receptors

2002 • 286 citations

Over One Hundred Peptide-Activated G Protein-Coupled Receptors Recognize Ligands with Turn Structure

2005 • 217 citations

The G-protein linked receptor facts book

1994 • 181 citations

Molecular architecture of G protein-coupled receptors

1996 • 178 citations

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

1988 • 174 citations

Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors

2005 • 170 citations

Structure-Function Analysis of the -Adrenergic Receptor

1988 • 145 citations

Three-dimensional modelling of G protein-linked receptors

1990 • 133 citations

Predicted 3D structure for the human β2 adrenergic receptor and its binding site for agonists and antagonists

2004 • 123 citations

Modeling the 3D structure of GPCRs: advances and application to drug discovery.

2003 • 77 citations

Toward the active conformations of rhodopsin and the β₂‐adrenergic receptor

2004 • 75 citations

A New Approach to Docking in the β₂-Adrenergic Receptor That Exploits the Domain Structure of G-Protein-Coupled Receptors

1997 • 73 citations

Three-Dimensional Models for β-Adrenergic Receptor Complexes with Agonists and Antagonists

2003 • 53 citations

Novel approach to computer modeling of seven-helical transmembrane proteins: current progress in the test case of bacteriorhodopsin.

2001 • 36 citations

Mutational Analysis of the Endothelin Type A Receptor (ET_A): Interactions and Model of the Selective ET_A Antagonist BMS-182874 with the Putative ET_A Receptor Binding Cavity

1996 • 21 citations

The Discovery and Development of Angiotensin II Antagonists

2006 • 19 citations