Functional heterogeneity of oxygen supply-consumption ratio in the heart

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1929 • 853 citations

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1987 • 592 citations

Microcirculatory oxygenation and shunting in sepsis and shock

1999 • 536 citations

Longitudinal Gradients in Periarteriolar Oxygen Tension

1970 • 460 citations

Morphometry of pig coronary arterial trees

1993 • 400 citations

Defining hypoxia: a systems view of VO2, glycolysis, energetics, and intracellular PO2

1990 • 390 citations

Fractal nature of regional myocardial blood flow heterogeneity.

1989 • 363 citations

Quantification of regional myocardial blood flow in vivo with H215O.

1984 • 361 citations

Localization and Kinetics of Reduced Pyridine Nucleotide in Living Cells by Microfluorometry

1959 • 251 citations

Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart.

1988 • 219 citations

Regional Distribution of Diffusible Tracers and Carbonized Microspheres in the Left Ventricle of Isolated Dog Hearts

1973 • 215 citations

Topology and dimensions of pig coronary capillary network

1994 • 201 citations

Ischemic Areas in Perfused Rat Hearts: Measurement by NADH Fluorescence Photography

1976 • 193 citations

Branching patterns in the porcine coronary arterial tree. Estimation of flow heterogeneity.

1992 • 168 citations

Regional myocardial flow heterogeneity explained with fractal networks

1989 • 164 citations

Heterogeneity of the hypoxic state in perfused rat heart.

1977 • 160 citations

Quantitative determination of regional oxygen consumption in the dog heart.

1978 • 159 citations

Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria.

1976 • 156 citations

Oxygen conformance of cellular respiration in hepatocytes

1993 • 151 citations

Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets

1991 • 134 citations

The Anatomy and Physiology of Capillaries

1923 • 134 citations

The capillary and sarcolemmal barriers in the heart. An exploration of labeled water permeability.

1977 • 126 citations

Inhibition of Nitric Oxide Synthesis Causes Myocardial Ischemia in Endotoxemic Rats

1995 • 122 citations

Arterioles supply oxygen to capillaries by diffusion as well as by convection

1990 • 122 citations

Regional oxygen saturation of small arteries and veins in the canine myocardium.

1978 • 120 citations

Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo

1996 • 112 citations

Fluorometric Studies of Oxidative Metabolism in Isolated Papillary Muscle of the Rabbit

1972 • 105 citations

Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation

1999 • 100 citations

Molecular and particulate depositions for regional myocardial flows in sheep.

1990 • 89 citations

pO2Measurements in Arteriolar Networks

1996 • 88 citations

Circulatory Transport of Iodoantipyrine and Water in the Isolated Dog Heart

1970 • 87 citations

Effect of substrate on mitochondrial NADH, cytosolic redox state, and phosphorylated compounds in isolated hearts

1995 • 86 citations

Heterogeneity of myocardial blood flow

1995 • 83 citations

Two and three dimensional display of myocardial ischemic “border zone” in dogs

1978 • 81 citations

Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes

1996 • 79 citations

Heterogeneity of the hypoxic state in rat heart is determined at capillary level

1993 • 74 citations

Role of Microvessels in Oxygen Supply to Tissue

1994 • 71 citations

Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study

1997 • 71 citations

Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone"

1994 • 70 citations

Influence of cardiac contraction and coronary vasomotor tone on regional myocardial blood flow

1994 • 68 citations

Water, sodium, and thiourea transcapillary diffusion in the dog heart

1967 • 59 citations

Spatial heterogeneity of blood flow in the dog heart. I. Glucose uptake, free adenosine and oxidative/glycolytic enzyme activity

1996 • 58 citations

Coronary Reserve of High- and Low-Flow Regions in the Dog Heart Left Ventricle

1998 • 49 citations

(Semi-)quantitative analysis of reduced nicotinamide adenine dinucleotide fluorescence images of blood-perfused rat heart

1997 • 47 citations

P<scp>o</scp>₂measurements in the rat intestinal microcirculation

1999 • 47 citations

Limitations of tracer oxygen uptake in the canine coronary circulation.

1985 • 44 citations

Visualization of the distance between perfusion and anoxia along an ischemic border.

1979 • 43 citations

Heterogeneity of oxygen delivery in normoxic and hypoxic states: a fluorometer study

1978 • 43 citations

Microheterogeneity of myocardial blood flow in rabbit hearts during normoxic and hypoxic states

1996 • 41 citations

Low-volume resuscitation with a hemoglobin-based oxygen carrier after hemorrhage improves gut microvascular oxygenation in swine

1998 • 35 citations

In vivo visualization of oxygen transport in microvascular network

1994 • 34 citations

Diffusional shunting in the canine myocardium.

1981 • 33 citations

Diffusional arteriovenous shunting in the heart

1984 • 27 citations

Precapillary O2 Loss and Arteriovenous O2 Diffusion Shunt are Below Limit of Detection in Myocardium

1989 • 24 citations

Capillary perfusion pattern and microvascular geometry in heterogeneous hypoxic areas of hypoperfused rat myocardium

1995 • 24 citations

Low- and high-blood flow regions in the normal pig heart are equally vulnerable to ischaemia during partial coronary stenosis

1997 • 22 citations

Heterogeneity of myocardial blood flow under normal conditions and its dependence on arterial PO2

1990 • 22 citations

Characterization of energy metabolism and blood flow distribution in myocardial ischemia in hemorrhagic shock

1997 • 21 citations

Discrepancy between microsphere and diffusible tracer estimates of perfusion to ischemic myocardium

1985 • 18 citations

Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis

1997 • 18 citations

Oxygen diffusion in a network model of the myocardial microcirculation.

1993 • 17 citations

Diffusional shunting of oxygen in saline-perfused isolated rabbit heart is negligible

1987 • 16 citations

Myocardial tissue perfusion determined by particulate and diffusible tracers during ischaemia: what is measured?

1996 • 13 citations

Myocardial surface Po2 - an indicator of myocardial tissue oxygenation?

1989 • 12 citations

Imminent ischemia in normal and hypertrophic Langendorff rat hearts; effects of fatty acids and superoxyde dismutase monitored by NADH suraface fluorescence

1993 • 12 citations

Heterogeneity of the coronary microcirculation during low-flow ischemia: a model for the heart in shock.

1980 • 9 citations

Ischemic Areas in Hypertrophic Langendorff Rat Hearts Visualized by NADH Videofluorimetry

1994 • 8 citations

Effect of Flow Reduction on Coronary Blood Flow Heterogeneity

1993 • 8 citations

Transport of inert gases in mammalian myocardium: comparison with a convection-diffusion model

1990 • 6 citations

Mitochondrial redox state as a “Gold Standard” of tissue hypoxia

1994 • 5 citations

Weak Spots Inside the Myocardium of a Langendorff Rat Heart Observed by Nadh Videofluorometry

1997 • 5 citations

Regional heterogeneity of myocardial blood flow within the rabbit left ventricle during haemorrhagic hypotension.

1992 • 3 citations