Cyclization of Geranylgeranyl Diphosphate to Taxa-4(5),11(12)-diene Is the Committed Step of Taxol Biosynthesis in Pacific Yew

Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1971 • 3,891 citations

Proton and carbon-13 assignments from sensitivity-enhanced detection of heteronuclear multiple-bond connectivity by 2D multiple quantum NMR

1986 • 2,445 citations

Multiple quantum filters for elucidating NMR coupling networks

1982 • 1,780 citations

Correlation of proton and nitrogen-15 chemical shifts by multiple quantum NMR

1983 • 1,262 citations

Clean TOCSY for proton spin system identification in macromolecules

1988 • 1,128 citations

An improved method for heteronuclear chemical shift correlation by two-dimensional NMR

1981 • 774 citations

Chemistry and Biology of Taxol

1994 • 614 citations

Taxol and taxotere: discovery, chemistry, and structure-activity relationships

1993 • 435 citations

Biosynthesis of isoprenoid compounds

1982 • 362 citations

The Taxol Supply Crisis. New NCI Policies for Handling the Large-Scale Production of Novel Natural Product Anticancer and Anti-HIV Agents

1993 • 306 citations

The chemistry of taxol

1991 • 250 citations

Taxus spp. Needles Contain Amounts of Taxol Comparable to the Bark of Taxus brevifolia: Analysis and Isolation

1990 • 237 citations

Taxol Content in Bark, Wood, Root, Leaf, Twig, and Seedling from Several Taxus Species

1990 • 168 citations

Defense Mechanisms of Conifers

1991 • 158 citations

Effects of Genetic, Epigenetic, and Environmental Factors on Taxol Content in Taxus brevifolia and Related Species

1992 • 153 citations

Cell Culture of Taxus as a Source of the Antineoplastic Drug Taxol and Related Taxanes

1992 • 136 citations

Taxane anticancer agents. Basic science and current status

1995 • 133 citations

Taxol and Derivatives: A Biogenetic Hypothesis

1987 • 100 citations

Initiation and growth of cell lines of Taxus brevifolia (Pacific yew)

1993 • 97 citations

Diterpenoid Resin Acid Biosynthesis in Conifers: Enzymatic Cyclization of Geranylgeranyl Pyrophosphate to Abietadiene, the Precursor of Abietic Acid

1994 • 81 citations

Biosynthesis of taxoids. Mode of formation of the taxol side chain

1993 • 67 citations

Taxol and Cephalomannine Concentrations in the Foliage and Bark of Shade-Grown and Sun-Exposed Taxus brevifolia Trees

1992 • 55 citations

Biosynthetic building blocks of taxanes

1992 • 51 citations

Biosynthesis of Taxoids. Mode of Attachment of the Taxol Side Chain

1994 • 46 citations

Factors influencing the in vitro production of radiolabeled taxol by Pacific yew, Taxus brevifolia

1992 • 44 citations

Seasonal and tissue variation in taxane concentrations of Taxus brevifolia

1994 • 44 citations

Distribution and Amounts of Taxol in Different Shoot Parts ofTaxus cuspidata

1992 • 43 citations

Taxol: the supply issue.

1991 • 42 citations

Total synthesis of verticillene. A biomimetic approach to the taxane family of alkaloids

1990 • 39 citations

Overview Oncologic, Metabolic & Endocrine: Taxol: a novel antitumour agent

1994 • 38 citations

Taxine. Part IV. The constitution of taxine-I

1966 • 37 citations

The isolation of seven new taxane derivatives from the heartwood of yew (Taxus baccata L.)

1969 • 36 citations

Taxol formation in yew — Taxus

1993 • 34 citations

Applications of gas chromatography to the study of terpenoid metabolism

1988 • 28 citations

Total Synthesis of Anticancer Agent Taxol Achieved by Two Different Routes

1994 • 23 citations

Meeting Demands for Breadth and Depth: A Two-Tiered Approach

1993 • 8 citations