Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

1975 • 1,358 citations

Relationship of cell growth to the regulation of tissue‐specific gene expression during osteoblast differentiation

1990 • 934 citations

Marrow stromal stem cells

1988 • 835 citations

Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures

1992 • 829 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Osteoporosis and the Replacement of Cell Populations of the Marrow by Adipose Tissue

1971 • 743 citations

Human bone cellsin vitro

1985 • 696 citations

Cellular and Molecular Aspects of Adipose Tissue Development

1992 • 671 citations

Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone.

1988 • 656 citations

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

1989 • 641 citations

Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes.

1980 • 593 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids

1984 • 500 citations

Transforming Growth Factor-β Gene Family Members and Bone*

1994 • 493 citations

Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells.

1979 • 481 citations

Characterization of New Oral Antidiabetic Agent CS-045: Studies in KK and ob/ob Mice and Zucker Fatty Rats

1988 • 459 citations

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

1994 • 450 citations

Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study

1987 • 450 citations

Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization

1990 • 436 citations

Quantitative histological data on disuse osteoporosis

1974 • 435 citations

CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

1994 • 433 citations

Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

1995 • 397 citations

Isolation and characterization of osteoblast precursor cells from human bone marrow

1996 • 397 citations

Osteogenic Stem Cells and the Stromal System of Bone and Marrow

1989 • 394 citations

Role of Cytokines in Inducing Hyperlipidemia

1992 • 385 citations

Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.

1985 • 364 citations

Adipocytic cells cultured from marrow have osteogenic potential

1991 • 363 citations

Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence.

1996 • 345 citations

Fat-cell changes as a mechanism of avascular necrosis of the femoral head in cortisone-treated rabbits

1977 • 338 citations

Histologic evidence for osteopenia and increased bone turnover in ovariectomized rats

1986 • 319 citations

Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 Adipocytes

1982 • 304 citations

1,25-Dihydroxyvitamin D₃and Human Bone-Derived Cells in Vitro: Effects on Alkaline Phosphatase, Type I Collagen and Proliferation*

1986 • 280 citations

Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators

1994 • 273 citations

Osteogenic stem cells in the bone marrow

1990 • 239 citations

Human Osteogenic Protein-1 Induces Chondroblastic, Osteoblastic, and/or Adipocytic Differentiation of Clonal Murine Target Cells

1996 • 238 citations

Sensitivity of corticosteroid-dependent insulin-resistant lipogenesis in marrow preadipocytes of obese-diabetic (db/db) mice

1978 • 231 citations

Peroxisome proliferator and retinoid signalingpathways co-regulate preadipocyte phenotype and survival.

1994 • 227 citations

Control of specific protein biosynthesis during the adipose conversion of 3T3 cells.

1980 • 217 citations

Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells

1993 • 204 citations

Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.

1992 • 198 citations

Fatty acids as signal transducing molecules: involvement in the differentiation of preadipose to adipose cells.

1994 • 194 citations

Measurement of serum osteocalcin with a human-specific two-site immunoradiometric assay

1992 • 193 citations

Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine.

1976 • 192 citations

Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells

1995 • 190 citations

Human bone tissue formation in diffusion chamber culture in vivo by bone-derived cells and marrow stromal fibroblastic cells

1995 • 166 citations

Stromal cell lines which support lymphocyte growth: characterization, sensitivity to radiation and responsiveness to growth factors

1988 • 158 citations

Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members

1993 • 154 citations

Age-related variations of fat tissue fraction in normal human bone marrow depend both on size and number of adipocytes: a stereological study.

1989 • 141 citations

Chylomicron metabolism

1989 • 139 citations

Clonal osteogenic cell lines express myogenic and adipocytic developmental potential

1991 • 137 citations

Cytokines induce catabolic effects in cultured adipocytes by multiple mechanisms

1994 • 137 citations

Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells.

1994 • 135 citations

Induction of aP2 gene expression by nonmetabolized long-chain fatty acids.

1992 • 121 citations

Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation.

1987 • 120 citations

Characterization of cells with high alkaline phosphatase activity derived from human bone and marrow: Preliminary assessment of their osteogenicity

1985 • 110 citations

Troglitazone prevents the inhibitory effects of inflammatory cytokines on insulin-induced adipocyte differentiation in 3T3-L1 cells.

1994 • 109 citations

The function of adipocytes in the bone marrow stroma.

1990 • 109 citations

Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto‐oncogenes in normal human osteoblast‐like cells

1992 • 101 citations

Hormonal responsiveness of a preadipose cell line derived from newborn mouse calvaria

1982 • 89 citations

Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs

1990 • 87 citations

Corticosteroid-dependent differentiation of human marrow preadipocytes in vitro

1979 • 83 citations

Clonal preadipocyte cell lines with different phenotypes derived from murine marrow stroma: Factors influencing growth and Adipogenesis in vitro

1982 • 83 citations

Effects of bovine parathyroid hormone and 1,25‐dihydroxyvitamin D₃ on the production of prostaglandins by cells derived from human bone

1984 • 80 citations

Regulation of adipose cell differentiation. II. Kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone.

1991 • 79 citations

Bone marrow adipose tissue: Response to acute starvation

1979 • 78 citations

Marrow adipose cells and hemopoiesis: an interpretative review.

1984 • 68 citations

Long-term culture of cells from bone affected by Paget’s disease

1979 • 64 citations

The Isolation and Culture of Cells from Explants of Human Trabecular Bone

1995 • 64 citations

Preadipocyte differentiation in vitro: Identification of a highly active adipogenic agent

1988 • 60 citations

Adipogenesis in a myeloid supporting bone marrow stromal cell line

1992 • 47 citations

Microcytophotometric analysis of human osteoclast metabolism: lack of activity in certain oxidative pathways indicates inability to sustain biosynthesis during resorption.

1994 • 40 citations

Regulation of gene expression in the adipocyte: implications for obesity and proto-oncogene function

1988 • 35 citations

Practical Histochemistry

1992 • 27 citations

IL-1 beta inhibits adipocyte formation in human long-term bone marrow culture.

1993 • 17 citations

P1. Bone formation in vivo by cultured human marrow stromal and trabecular bone-derived cells

1994 • 5 citations

O4. Osteogenic and adipogenic differentiation in human bone derived cell cultures

1994 • 3 citations