Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1999 • 6,580 citations

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

2002 • 1,039 citations

An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT

1991 • 994 citations

Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

1992 • 917 citations

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

1989 • 689 citations

Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 Ψ-RNA Recognition Element

1998 • 631 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replication

1998 • 383 citations

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

1990 • 380 citations

A role for surface hydrophobicity in protein‐protein recognition

1994 • 377 citations

Synthesis of Fluorinated Fluoresceins

1997 • 291 citations

The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent

1993 • 236 citations

Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS

1995 • 228 citations

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds

1993 • 198 citations

Sequence-Specific Binding of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein to Short Oligonucleotides

1998 • 172 citations

The Human Immunodeficiency Virus Type 1 Gag Polyprotein Has Nucleic Acid Chaperone Activity: Possible Role in Dimerization of Genomic RNA and Placement of tRNA on the Primer Binding Site

1999 • 150 citations

Reactivity of Zinc Finger Cores: Analysis of Protein Packing and Electrostatic Screening

2001 • 143 citations

Human immunodeficiency virus type 1 nucleocapsid protein reduces reverse transcriptase pausing at a secondary structure near the murine leukemia virus polypurine tract

1996 • 135 citations

Nucleic Acid Sequence Discrimination by the HIV-1 Nucleocapsid Protein NCp7: A Fluorescence Study

1999 • 126 citations

Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site

1996 • 126 citations

Anti-HIV Agents That Selectively Target Retroviral Nucleocapsid Protein Zinc Fingers without Affecting Cellular Zinc Finger Proteins

1998 • 123 citations

Inhibition of the red blood cell calcium pump by eosin and other fluorescein analogues

1993 • 118 citations

A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design

1995 • 117 citations

Synthesis and Biological Properties of Novel Pyridinioalkanoyl Thiolesters (PATE) as Anti-HIV-1 Agents That Target the Viral Nucleocapsid Protein Zinc Fingers

1998 • 106 citations

Formation of Stable and Functional HIV-1 Nucleoprotein Complexesin Vitro

1995 • 104 citations

The interaction of tetra-iodofluorescein with dogfish muscle lactate dehydrogenase: A chemical and X-ray crystallographic study

1971 • 86 citations

Inhibitors of Kinesin Activity from Structure-Based Computer Screening

2000 • 78 citations

The Role of Pr55 ^gag in the Annealing of tRNA ₃ ^Lys to Human Immunodeficiency Virus Type 1 Genomic RNA

1999 • 63 citations

Effect of Solvent–Water Mixtures on the Prototropic Equilibria of Fluorescein and on the Spectral Properties of the Monoanion¶

2000 • 61 citations

Docking enzyme‐inhibitor complexes using a preference‐based free‐energy surface

1996 • 51 citations

Interaction of tetraiodofluorescein with aspartate transcarbamylase and its isolated catalytic and regulatory subunits.

1975 • 50 citations

Identification of a Key Target Sequence To Block Human Immunodeficiency Virus Type 1 Replication within the gag-pol Transframe Domain

2000 • 50 citations

Binding of the Fluorescein Derivative Eosin Y to the Mitochondrial ADP/ATP Carrier: Characterization of the Adenine Nucleotide Binding Site

1998 • 42 citations

A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity

1999 • 40 citations

Properties of Small Molecules Affecting Insulin Receptor Function

2001 • 29 citations

The interaction of tetraiodofluorescein with creatine kinase

1977 • 25 citations

HIV‐1ヌクレオカプシド蛋白質模倣体は逆転写を阻害し,抗ウイルス活性を示す

1999 • 19 citations

Replacement of His²³ by Cys in a zinc finger of HIV‐1 NC_p7 led to a change in ¹H NMR‐derived 3D structure and to a loss of biological activity

1993 • 17 citations

HIV-1 NCp7 as a target for the design of novel antiviral agents.

2000 • 12 citations

Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities

1999 • 12 citations

Evidence and Prevention of HIV-1 Nucleocapsid Protein Adsorption onto Fluorescence Quartz Cells

1997 • 10 citations

Structural analysis of inhibitor binding to HIV-1 protease: identification of a common binding motif

1998 • 7 citations

Deleted Work

1955 • 0 citations