Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial

Generalized Linear Models

2005 • 21,170 citations

Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial

1997 • 511 citations

A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer

1997 • 477 citations

Time-dose factors in radiotherapy: a review of the human data

1990 • 406 citations

Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer – report on 3-year tumour control and normal tissue toxicity

2000 • 162 citations

Dose and volume effects on fibrosis after breast conservation therapy

1994 • 162 citations

The recording of morbidity related to radiotherapy

1989 • 153 citations

Do acute mucosal reactions lead to consequential late reactions in patients with head and neck cancer?

1999 • 150 citations

A modelled comparison of the effects of using different ways to compensate for missed treatment days in radiotherapy

1996 • 134 citations

Randomized clinical trial on accelerated 7 days per week fractionation in radiotherapy for head and neck cancer. Preliminary report on acute toxicity

1996 • 126 citations

Repair halftimes estimated from observations of treatment-related morbidity after CHART or conventional radiotherapy in head and neck cancer

1999 • 123 citations

Three A's of repopulation during fractionated irradiation of squamous epithelia: Asymmetry loss, Acceleration of stem-cell divisions and Abortive divisions

1997 • 114 citations

Current radiation oncology

1996 • 112 citations

The effect of irradiation on function in self-renewing normal tissues with differing proliferative organisation

1982 • 110 citations

Morbidity Related to Axillary Irradiation in the Treatment of Breast Cancer

2000 • 105 citations

Radiation therapy in the management of cancers of the oral cavity and oropharynx

1962 • 79 citations

Altered fractionation: limited by mucosal reactions?

1999 • 73 citations

Repair capacity and kinetics for human mucosa and epithelial tumors in the head and neck: clinical data on the effect of changing the time interval between multiple fractions per day in radiotherapy

1996 • 68 citations

Accelerated fractionation radiotherapy for laryngeal cancer, acute, and late toxicity

1992 • 64 citations

Mucosal regeneration during radiotherapy

1996 • 63 citations

Steepness of the Clinical Dose–control Curve and Variation in thein VitroRadiosensitivity of Head and Neck Squamous Cell Carcinoma

1992 • 60 citations

Characteristics of dose-response relationships for late radiation effects: an analysis of skin telangiectasia and of head and neck morbidity

1991 • 41 citations

Repopulation in mouse oral mucosa: changes in the effect of dose fractionation

2000 • 38 citations

Acute reaction parameters for human oropharyngeal mucosa

1995 • 32 citations

Apparent rates of proliferation of acutely responding normal tissues during radiotherapy of head and neck cancer

1991 • 31 citations

Radiotherapy in the elderly

1998 • 26 citations

The clinical significance of ratios of radiobiological parameters

1996 • 25 citations

Repopulation in mouse oral mucosa: treatment splits

1994 • 19 citations

Effect of Changing Weekly Dose on Accelerated Repopulation during Fractionated Irradiation of Mouse Tongue Mucosa

1995 • 18 citations

Conventional vs accelerated fractionation in head and neck cancer.

1996 • 12 citations

Properties of maximum likelihood estimates of the ratio of parameters in ordinal response regression models

1990 • 7 citations