Prefrontal Cortex Cognitive Deficits in Children Treated Early and Continuously for PKU

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Construction Of Reality In The Child

2013 • 4,612 citations

Attention to Action

1986 • 4,309 citations

Forest before trees: The precedence of global features in visual perception

1977 • 3,872 citations

The frontal lobes

1986 • 2,138 citations

A SIMPLE PHENYLALANINE METHOD FOR DETECTING PHENYLKETONURIA IN LARGE POPULATIONS OF NEWBORN INFANTS

1963 • 2,115 citations

Neuron Activity Related to Short-Term Memory

1971 • 2,071 citations

Fundamentals of Human Neuropsychology

1995 • 2,015 citations

The relationship between cognition and action: performance of children 312–7 years old on a stroop- like day-night test

1994 • 1,502 citations

The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm.

1990 • 1,499 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory

1991 • 1,365 citations

Word fluency and brain damage

1967 • 1,284 citations

Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man

1982 • 1,277 citations

Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus

1978 • 1,196 citations

Motor sequence learning: a study with positron emission tomography

1994 • 1,159 citations

The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour☆

1974 • 1,015 citations

Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades

1985 • 1,014 citations

Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory.

1973 • 1,007 citations

The Frontal Lobes and Voluntary Action

1993 • 984 citations

Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys

1993 • 908 citations

Functional activation of the human frontal cortex during the performance of verbal working memory tasks.

1993 • 905 citations

Cortical areas and the selection of movement: a study with positron emission tomography

1991 • 900 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Disorders of Learning and Memory after Temporal Lobe Lesions in Man

1972 • 878 citations

Visual Experience in Infants: Decreased Attention to Familiar Patterns Relative to Novel Ones

1964 • 876 citations

Response suppression, initiation and strategy use following frontal lobe lesions

1996 • 832 citations

Investigations of the functional anatomy of attention using the stroop test

1993 • 813 citations

Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment

1989 • 763 citations

An age-related dissociation between knowing rules and using them

1996 • 727 citations

Development of an aspect of executive control: Development of the abilities to remember what I said and to ?Do as I say, not as I do?

1996 • 708 citations

Prefrontal cortical unit activity and delayed alternation performance in monkeys.

1971 • 703 citations

Dissociation of human mid-dorsolateral from posterior dorsolateral frontal cortex in memory processing.

1993 • 669 citations

Comparison of human infants and rhesus monkeys on Piaget's AB task: evidence for dependence on dorsolateral prefrontal cortex

1989 • 618 citations

Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI

1994 • 581 citations

Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey

1970 • 581 citations

Dissociating executive functions of the prefrontal cortex

1996 • 574 citations

Development of the Ability to Use Recall to Guide Action, as Indicated by Infants' Performance on AB

1985 • 534 citations

Developmental Time Course in Human Infants and Infant Monkeys, and the Neural Bases of, Inhibitory Control in Reachinga

1990 • 525 citations

TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER¹

1977 • 525 citations

Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients

1990 • 508 citations

Effects of lesions of temporal-parietal junction on perceptual and attentional processing in humans

1988 • 478 citations

Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey

1995 • 461 citations

Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys

1986 • 459 citations

The development and neural bases of higher cognitive functions

1990 • 446 citations

Infant Perception: from Sensation to Cognition

1975 • 444 citations

Specialized systems for the processing of mnemonic information within the primate frontal cortex

1996 • 442 citations

Some cognitive effects of frontal-lobe lesions in man

1982 • 424 citations

Frontal lobe and frontal-striatal substrates for different forms of human cognitive flexibility

1993 • 421 citations

Memory in the infant

1970 • 414 citations

Light Stimulates Tyrosine Hydroxylase Activity and Dopamine Synthesis in Retinal Amacrine Neurons

1978 • 396 citations

The Frontal Lobes Revisited

2019 • 394 citations

The Development and Neural Bases of Memory Functions as Indexed by the AB and Delayed Response Tasks in Human Infants and Infant Monkeysa

1990 • 376 citations

Brain Catechol Synthesis: Control by Brain Tyrosine Concentration

1974 • 367 citations

Dopaminergic A10 neurones are involved in cognitive functions

1980 • 362 citations

Frontal-lobe contribution to recency judgements

1991 • 359 citations

Cloned human phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria

1983 • 334 citations

Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man

1996 • 318 citations

The Influence of Phenylalanine Intake on the Chemistry and Behaviour of a Phenylketonuria Child

1954 • 297 citations

Infant Visual Memory

1975 • 290 citations

Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients

1990 • 290 citations

VISUAL DYSFUNCTION IN PARKINSON'S DISEASE

1987 • 289 citations

Neuropsychological Insights into the Meaning of Object Concept Development

2014 • 279 citations

Neuropsychology of Early-treated Phenylketonuria: Specific Executive Function Deficits

1990 • 279 citations

Local and global processing: The role of sparsity

1979 • 277 citations

Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist

1992 • 276 citations

Delayed-matching and delayed-response deficit from cooling dorsolateral prefrontal cortex in monkeys.

1976 • 276 citations

Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography.

1995 • 274 citations

Human amnesia and animal models of amnesia: Performance of amnesic patients on tests designed for the monkey.

1988 • 259 citations

6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze

1990 • 253 citations

The performance of human infants on a measure of frontal cortex function, the delayed response task

1989 • 251 citations

Tight linkage between a splicing mutation and a specific DNA haplotype in phenylketonuria

1986 • 249 citations

DRAWING DISABILITY IN RELATION TO LATERALITY OF CEREBRAL LESION

1966 • 245 citations

Comparison of the effects of frontal and caudate lesions on delayed response and alternation in monkeys.

1960 • 241 citations

Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys

1990 • 236 citations

Mouse models of human phenylketonuria.

1993 • 233 citations

The effects of high phenylalanine concentrations on serotinin and catecholamine metabolism in the human brain

1972 • 223 citations

Do As I Say, Not As I Do

1994 • 222 citations

Infants' delayed recognition memory and forgetting

1973 • 218 citations

Component mechanisms underlying the processing of hierarchically organized patterns: Inferences from patients with unilateral cortical lesions.

1990 • 208 citations

On the development of declarative memory.

1993 • 202 citations

The frontal cortex and memory for temporal order

1991 • 201 citations

Tryptophan Hydroxylation in Mammalian Systems

1968 • 194 citations

Biochemical and neuropsychological effects of elevated plasma phenylalanine in patients with treated phenylketonuria. A model for the study of phenylalanine and brain function in man.

1985 • 192 citations

CNS Dopamine Autoreceptors: Distribution, Pharmacology, and Function^a

1984 • 185 citations

Uptake of Tyrosine by Rat Brain in Vivo

1960 • 182 citations

Attention and interference in the processing of global and local information: Effects of unilateral temporal-parietal junction lesions

1989 • 172 citations

Effect of Age at Loss of Dietary Control on Intellectual Performance and Behavior of Children with Phenylketonuria

1986 • 167 citations

An early and a late developing system for learning and retention in infant monkeys.

1984 • 165 citations

The monoaminergic innervation of primate neocortex.

1986 • 164 citations

Limbic-dependent recognition memory in monkeys develops early in infancy

1993 • 162 citations

Stereospecificity of blood-brain barrier permeability to amino acids

1973 • 159 citations

Low-contrast letter charts in early diabetic retinopathy, ocular hypertension, glaucoma, and Parkinson's disease.

1984 • 159 citations

Dopamine synthesis and metabolism in rhesus monkey retina: Development, aging, and the effects of monocular visual deprivation

1989 • 158 citations

Analysis of discrimination learning by monkeys.

1950 • 153 citations

Studies of cerebral function in primates. IV. The effects of frontal lobe lesions on the delayed alternation habit in monkeys.

1937 • 152 citations

The effects of selective caudate lesions in infant and juvenile rhesus monkeys

1972 • 151 citations

Characterizing amnesic patients for neurobehavioral study.

1986 • 151 citations

Selective ablations within the prefrontal cortex of the rat and performance of delayed alternation

1978 • 146 citations

‘Part-whole’ processing in unilateral brain- damaged patients: Dysfunction of hierarchical organization

1986 • 143 citations

The role of the inferior prefrontal convexity in performance of delayed nonmatching-to-sample

1991 • 141 citations

Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase.

1990 • 138 citations

Mesocortical dopamine neurons: rapid transmitter turnover compared to other brain catecholamine systems.

1981 • 131 citations

The Mental Changes Due to Frontal Lobe Damage

1944 • 130 citations

The Frontal Lobes and Control of Cognition and Memory

2019 • 129 citations

Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants.

1989 • 129 citations

Brain Maturation and Cognitive Development: Comparative and Cross-cultural Perspectives

1991 • 126 citations

Noradrenergic innervation of monkey prefrontal cortex: A dopamine‐β‐hydroxylase immunohistochemical study

1989 • 125 citations

Strategic processing and memory for temporal order in patients with frontal lobe lesions.

1997 • 118 citations

Behavioral and Neuropharmacological Correlates of Nigrostriatal Asymmetry in Rats

1977 • 117 citations

Phenylalanine as substrate and inhibitor of tyrosine hydroxylase

1967 • 116 citations

Effect on intelligence of relaxing the low phenylalanine diet in phenylketonuria.

1991 • 114 citations

Sustained attention in adult phenylketonuria: The influence of the concurrent phenylalanine-blood-level

1994 • 110 citations

Delayed response deficit by cryogenic depression of frontal cortex

1970 • 110 citations

An experimental investigation of Luria's theory on the effects of frontal lobe lesions in man

1975 • 109 citations

Visual System Abnormalities in Patients With Parkinson's Disease

1982 • 108 citations

Early-treated phenylketonuria: Adult neuropsychologic outcome

1994 • 107 citations

Evidence of Robust Recognition Memory Early in Life Even When Assessed by Reaching Behavior

1995 • 105 citations

Kinetic Constants for Blood—Brain Barrier Amino Acid Transport in Conscious Rats

1985 • 103 citations

An animal model of early-treated PKU

1994 • 101 citations

Intellectual Development and Academic Achievement of Children Treated Early for Phenylketonuria

1979 • 100 citations

Dopaminergic mechanisms in vision

1989 • 99 citations

Effects of Fornix Transection on Spontaneous and Trained Non-Matching by Monkeys

1984 • 99 citations

Behavior disturbance in 8-year-old children with early treated phenylketonuria

1988 • 98 citations

Frontal Lobe Involvement in Cognitive Changes During the First Year of Life

2017 • 96 citations

Dietary problems of phenylketonuria: Effect on CNS transmitters and their possible role in behaviour and neuropsychological function

1986 • 96 citations

Evidence for Central Nervous System Glial Cell Plasticity in Phenylketonuria

1996 • 95 citations

Neuropsychological deficits in early treated phenylketonuric children.

1985 • 95 citations

Correlates of Intelligence Test Results in Treated Phenylketonuric Children

1981 • 94 citations

α-Methylphenylalanine, a New Inducer of Chronic Hyperphenylalaninemia in Suckling Rats

1976 • 86 citations

Intellectual Assessment of 111 Four-Year-Old Children With Phenylketonuria

1977 • 85 citations

One-trial object-discrimination learning in monkeys with frontal lesions.

1962 • 83 citations

Effects of object preferences and aversions on discrimination learning in monkeys with frontal lesions.

1961 • 80 citations

Behavioral deficits in monkeys after selective lesions within the middle third of sulcus principalis.

1971 • 78 citations

Mesocortical dopamine neurons: High basal firing frequency predicts tyrosine dependence of dopamine synthesis

1990 • 77 citations

Early-treated phenylketonuria: Neuropsychologicconsequences

1983 • 74 citations

Carrier-mediated transport of amino acids through the blood-retinal and the blood-brain barriers

1986 • 68 citations

Neurological findings in early treated phenylketonuria

1995 • 67 citations

Preliminary report on the effects of diet discontinuation in PKU

1982 • 61 citations

Studies on phenylalanine and tyrosine hydroxylation by rat brain tyrosine hydroxylase

1976 • 61 citations

Phenylketonuria and Its Variants

1983 • 59 citations

The introduction of newborn screening for phenylketonuria

1996 • 59 citations

Effects of Phenylalanine on the Release of Endogenous Dopamine from Rat Striatal Slices

1986 • 56 citations

Molecular Analysis of the Inheritance of Phenylketonuria and Mild Hyperphenylalaninemia in Families with Both Disorders

1986 • 56 citations

Persistent Mild Hyperphenylalaninemia in the Untreated State

1971 • 55 citations

Normal global-local analysis in patients with dorsolateral frontal lobe lesions

1991 • 55 citations

Phenylalanine Transport at the Human Blood-Brain Barrier

1988 • 55 citations

PHENYLKETONURIA AND COMPLEX SPATIAL VISUALIZATION: AN ANALYSIS OF INFORMATION PROCESSING

1987 • 50 citations

Young children's performance on a task sensitive to the memory functions of the medial temporal lobe in adults: The delayed nonmatching-to-sample task reveals problems that are due to non-memory-related task demands.

1994 • 49 citations

Intelligence in mild atypical phenylketonuria

1994 • 47 citations

Preliminary neuropsychological test results

1990 • 46 citations

Regionally-specific alterations in mesotelencephalic dopamine synthesis in diabetic rats: association with precursor tyrosine

1989 • 46 citations

Cognitive development among children with early‐treated phenylketonuria

1994 • 45 citations

Association between learning and cortical catecholamines in non-drug-treated rats

1985 • 44 citations

Neuropsychological Functioning in Treated Phenylketonuria

1987 • 40 citations

Lateralized deficits in visual attention in males with developmental dopamine depletion

1992 • 40 citations

The Formation and Development of Perceptual Activity

1963 • 40 citations

Speech-action coordination in young children.

1984 • 40 citations

Amino Acid Availability and Brain Function in Health and Disease

1991 • 39 citations

Responses of phenylketonuric children on a continuous performance test.

1969 • 38 citations

A test of the frontal‐specificity hypothesis in the cognitive performance of adults with phenylketonuria

1996 • 37 citations

Discovery of the mesocortical dopaminergic system: some pharmacological and functional characteristics.

1977 • 34 citations

Alterations of visual contrast sensitivity in Parkinson's disease.

1986 • 34 citations

Dietary Phenylalanine and Brain Function

1988 • 32 citations

The Justification Theory: The Essential Nature of the Non-Essential Amino Acids

2009 • 27 citations

Disturbed myelinogenesis and recovery in hyperphenylalaninemia in rats: An immunohistochemical study

1992 • 25 citations

In vivo inhibition of tyrosine uptake into rat retina by large neutral but not acidic amino acids

1986 • 25 citations

Modulation of cerebral catecholamine concentrations during hyperphenylalaninaemia

1982 • 21 citations

Some observations on the dietary treatment of phenylketonuria

1968 • 19 citations

The phenylalanine response curve in relation to growth and mental development in the first years of life

1994 • 18 citations

The effects of instability of the visual display on pattern discrimination learning by monkeys: Dissociation produced after resections of frontal and inferotemporal cortex

1977 • 18 citations

Sustained Attention in Untreated Non-PKU-Hyperphenylalaninemia

1996 • 18 citations

In vivo tyrosine hydroxylation rate in retina: effects of phenylalanine and tyrosine administration in rats pretreated with p-chlorophenylalanine

1989 • 14 citations

Release of norepinephrine from rat hypothalamic slices: effects of desipramine and tyrosine

1987 • 10 citations

Developmental changes of cerebral phenylalanine uptake from severely elevated blood levels

1984 • 9 citations

Biochemical and nutritional status of children with hyperphenylalaninaemia

1988 • 8 citations

Inhibition of cerebral protein kinase activity and cyclic AMP-dependent ribosomal-protein phosphorylation in experimental hyperphenylalaninaemia

1982 • 8 citations

Demyelination in Hyperphenylalaninemia

1990 • 5 citations

Developmental Changes in Cerebral Amino Acids and Protein Metabolism

1988 • 4 citations

Deleted Work

1955 • 0 citations