Physiology and pathophysiology of the aquaporin-2 water channel

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane.

1995 • 1,017 citations

Requirement of Human Renal Water Channel Aquaporin-2 for Vasopressin-dependent Concentration of Urine

1994 • 870 citations

Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney.

1993 • 709 citations

THE LDL RECEPTOR LOCUS IN FAMILIAL HYPERCHOLESTEROLEMIA: Mutational Analysis of a Membrane Protein

1990 • 684 citations

Defective protein folding as a basis of human disease

1995 • 540 citations

Phosphorylation of Serine 256 Is Required for cAMP-dependent Regulatory Exocytosis of the Aquaporin-2 Water Channel

1997 • 465 citations

Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla.

1995 • 437 citations

Regulation of collecting duct water channel expression by vasopressin in Brattleboro rat.

1994 • 395 citations

Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct.

1997 • 358 citations

Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex.

1996 • 295 citations

Upregulation of aquaporin-2 water channel expression in chronic heart failure rat.

1997 • 289 citations

Protein Degradation or Regulation: Ub the Judge

1996 • 275 citations

Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing.

1995 • 243 citations

Transcriptional regulation of aquaporin-2 water channel gene by cAMP.

1997 • 228 citations

Role of renal aquaporins in escape from vasopressin-induced antidiuresis in rat.

1997 • 228 citations

cAMP-dependent Phosphorylation Stimulates Water Permeability of Aquaporin-collecting Duct Water Channel Protein Expressed in Xenopus Oocytes

1995 • 217 citations

Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene.

1994 • 204 citations

Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct

1997 • 193 citations

The protein machinery of vesicle budding and fusion

1996 • 181 citations

Expression and distribution of aquaporin of collecting duct are regulated by vasopressin V2 receptor in rat kidney.

1994 • 176 citations

New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels.

1997 • 175 citations

Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells.

1995 • 173 citations

The genetics of primary nocturnal enuresis: inheritance and suggestion of a second major gene on chromosome 12q.

1997 • 163 citations

cAMP motifs regulating transcription in the aquaporin 2 gene

1996 • 160 citations

Expression of VAMP-2-like protein in kidney collecting duct intracellular vesicles. Colocalization with Aquaporin-2 water channels.

1995 • 158 citations

Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking.

1996 • 137 citations

Hormonal Signaling and Regulation of Salt and Water Transport in the Collecting Duct

1994 • 122 citations

Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.

1997 • 112 citations

Reduced renal medullary water channel expression in puromycin aminonucleoside--induced nephrotic syndrome.

1997 • 107 citations

Increased gene expression of water channel in cirrhotic rat kidneys

1995 • 104 citations

Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro.

1995 • 95 citations

Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet.

1996 • 92 citations

Phosphorylation of Aquaporin-2 Does Not Alter the Membrane Water Permeability of Rat Papillary Water Channel-containing Vesicles

1996 • 89 citations

Expression and Functional Analysis of Water Channels in a Stably AQP2-transfected Human Collecting Duct Cell Line

1996 • 86 citations

The aquaporin family of water channels in kidney: An update on physiology and pathophysiology of aquaporin-2

1996 • 85 citations

Autosomal Recessive Nephrogenic Diabetes Insipidus Caused by an Aquaporin-2 Mutation*

1997 • 66 citations

Identification of Rab3‐, Rab5a‐ and synaptobrevin II‐like proteins in a preparation of rat kidney vesicles containing the vasopressin‐regulated water channel

1995 • 56 citations

Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12→q13

1994 • 50 citations

Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus

1996 • 43 citations

Role of Vasopressin V2 Receptor in Acute Regulation of Aquaporin-2

1996 • 34 citations

Regulation of Aquaporin-2 Gene Transcription by GATA-3

1997 • 34 citations

Role of Vasopressin in Rats with Bilateral Ureteral Obstruction

1991 • 28 citations