Chemokine blockers – therapeutics in the making?

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease

1999 • 2,174 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Chemokines

1997 • 1,926 citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

Chemokines and disease

2001 • 1,371 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

A Critical Role for Eosinophils in Allergic Airways Remodeling

2004 • 851 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

2003 • 756 citations

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

2005 • 735 citations

Defining a Link with Asthma in Mice Congenitally Deficient in Eosinophils

2004 • 701 citations

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

2000 • 580 citations

Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines

1997 • 512 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

2000 • 430 citations

Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent Antagonist

1996 • 424 citations

Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity

1998 • 409 citations

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

2002 • 385 citations

Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5

2004 • 358 citations

Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma

2002 • 350 citations

Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residues.

1995 • 288 citations

The BBXB Motif of RANTES Is the Principal Site for Heparin Binding and Controls Receptor Selectivity

2001 • 250 citations

Efficacy and Safety of a Monoclonal Antibody Recognizing Interleukin-8 in COPD

2004 • 244 citations

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 • 243 citations

CCR1+/CCR5+ Mononuclear Phagocytes Accumulate in the Central Nervous System of Patients with Multiple Sclerosis

2001 • 240 citations

Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

2003 • 240 citations

Two-site binding of C5a by its receptor: analternative binding paradigm for G protein-coupled receptors.

1994 • 236 citations

Magic bullets for protein kinases

2001 • 233 citations

Identification of C5ades arg and an Anionic Neutrophil-Activating Peptide (ANAP) in Psoriatic Scales

1986 • 230 citations

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation

2002 • 209 citations

Fully human anti-interleukin-8 monoclonal antibodies: potential therapeutics for the treatment of inflammatory disease states

1999 • 171 citations

A Dominant Negative Inhibitor Indicates that Monocyte Chemoattractant Protein 1 Functions as a Dimer

1995 • 158 citations

Interference with Heparin Binding and Oligomerization Creates a Novel Anti-Inflammatory Strategy Targeting the Chemokine System

2004 • 155 citations

Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors

1999 • 154 citations

Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB.

2003 • 149 citations

The X-Ray Structure of RANTES

2004 • 99 citations

Multi-faceted strategies to combat disease by interference with the chemokine system

2005 • 89 citations

Identification of nonpeptidic small-molecule inhibitors of interleukin-2

2005 • 22 citations

Plasma level of IL-8 in patients with psoriasis and its correlation with psoriasis area and severity index and the clinical type of the disease.

2000 • 3 citations