Concept of internal structural controls for evaluation of inactive synthetic peptide analogs: synthesis of [Orn13,14]apamin and its guanidination to an apamin derivative with full neurotoxic activity.

Solid Phase Peptide Synthesis

1976 • 1,798 citations

Solid‐Phase Peptide Synthesis

1969 • 624 citations

Hormonal Proteins and Peptides

1979 • 428 citations

Verbesserte Synthese von tert.‐Butyloxycarbonyl‐aminosäuren durch pH‐Stat‐Reaktion

1967 • 383 citations

Rapid fluorometric detection for completeness in solid phase coupling reactions

1973 • 120 citations

Structure-function relations and site of action of apamin, a neurotoxic polypeptide of bee venom with an action on the central nervous system

1975 • 108 citations

CHEMICAL DERIVATIVES OF CHYMOTRYPSINOGEN

1956 • 99 citations

Preparation and use of benzhydrylamine polymers in peptide synthesis. II. Synthesis of thyrotropin releasing hormone, thyrocalcitonin 26-32, and eledoisin

1974 • 79 citations

THE SYNTHESIS OF A TETRADECAPEPTIDE RENIN SUBSTRATE

1958 • 74 citations

Chemistry and Function of Polypeptide Hormones

1962 • 70 citations

The disulphide bridges of apamin

1968 • 68 citations

Synthesis of Apamin, a Neurotoxic Peptide from Bee Venom

1975 • 64 citations

Mechanism of Pulmonary Conversion of Anglotensin II to Angiotensin II in the Dog

1971 • 53 citations

Solid-phase synthesis of [2-isoleucine, 4-leucine]oxytocin and [2-phenylalanine, 4-leucine]oxytocin and some of their pharmacological properties

1973 • 40 citations

Biologically Active Citrulline Peptides

1962 • 32 citations

Active derivatives of a polypeptide inhibitor of trypsin (Kunitz and Northrop inhibitor)

1967 • 19 citations

[Sequence analysis of bee venom neurotoxin (apamine) from its tryptic and chymotryptic cleavage products].

1967 • 19 citations

SYNTHESIS OF PEPTIDE ANALOGS OF THE N‐TERMINAL EICOSAPEPTIDE SEQUENCE OF RIBONUCLEASE A.

1972 • 12 citations

Apamin from bee venom: effects of the neurotoxin on cultures of the embryonic mouse cortex.

1973 • 11 citations

Synthesis of an enzymatically active ORN10-S-peptide of ribonuclease-S

1966 • 7 citations