The sick motoneurone hypothesis of muscular dystrophy

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses

1960 • 1,103 citations

Cell Adhesion Molecules

1983 • 1,017 citations

The orderly recruitment of human motor units during voluntary isometric contractions

1973 • 910 citations

Polyneuronal innervation of skeletal muscle in new‐born rats and its elimination during maturation.

1976 • 774 citations

Invited review: Neural control of phenotypic expression in mammalian muscle fibers

1985 • 734 citations

Physiological changes in ageing muscles

1973 • 720 citations

Neuromuscular transmission in new‐born rats

1970 • 701 citations

The Structure and Function of Muscle

1973 • 661 citations

Electrophysiological estimation of the number of motor units within a human muscle

1971 • 650 citations

Disorders of Voluntary Muscle

1965 • 576 citations

The numbers of limb motor neurons in the human lumbosacral cord throughout life

1977 • 574 citations

Mouse Chimæras Developed from Fused Eggs

1961 • 567 citations

Specific cloning of DNA fragments absent from the DNA of a male patient with an X chromosome deletion.

1985 • 455 citations

Reduction of the naturally occurring motor neuron loss by enlargement of the periphery

1976 • 425 citations

A study of foetal and new‐born rat muscle fibres

1962 • 408 citations

The effects of wing bud extirpation on the development of the central nervous system in chick embryos

1934 • 389 citations

CHRONIC PROGRESSIVE MYOPATHY WITH MYOGLOBINURIA: DEMONSTRATION OF A GLYCOGENOLYTIC DEFECT IN THE MUSCLE*

1959 • 308 citations

QUANTAL COMPONENTS OF END‐PLATE POTENTIALS IN THE MYASTHENIC SYNDROME*

1971 • 304 citations

Heredofamilial Juvenile muscular Atrophy Simulating muscular Dystrophy

1956 • 286 citations

Mapping of motor units in experimentally reinnervated rat muscle: Interpretation of histochemical and atrophic fibre patterns in neurogenic lesions

1970 • 260 citations

Abnormalities of peripheral nerves in murine muscular dystrophy

1973 • 259 citations

Neuromuscular blockade increases motoneurone survival during normal cell death in the chick embryo

1978 • 246 citations

Motor unit organization of human medial gastrocnemius.

1979 • 235 citations

Cell Lineage Analysis by Intracellular Injection of a Tracer Enzyme

1978 • 233 citations

Infantile Muscular Atrophy

1961 • 228 citations

The origin and development of the visceral in the spinal cord of the chick embryo

1950 • 211 citations

"Myopathic" Changes in Chronically Denervated Muscle

1967 • 193 citations

Spontaneous electrical activity of human muscle

1966 • 184 citations

MENTAL DEFICIENCY ASSOCIATED WITH MUSCULAR DYSTROPHY

1966 • 174 citations

Morphology and physiology of skeletal muscle in aging rodents

1979 • 170 citations

THE REACTION OF MUSCLE TO DENERVATION

1939 • 170 citations

Ephaptic transmission between single nerve fibres in the spinal nerve roots of dystrophic mice.

1980 • 167 citations

Polyneuronal innervation of kitten skeletal muscle

1973 • 160 citations

The Innervation of Muscle: A. Biopsy Study

1960 • 158 citations

The prenatal development of behavior in the albino rat

1932 • 145 citations

Duchenne Muscular Dystrophy Involving Translocation of the dmd Gene Next to Ribosomal RNA Genes

1984 • 128 citations

Fast and slow twitch units in a human muscle

1971 • 127 citations

Dystrophia muscularis progressiva

1891 • 121 citations

Congenital Muscular Dystrophy as a Disease of the Central Nervous System

1976 • 116 citations

Motor unit estimations in small muscles of the hand

1974 • 114 citations

Electrophysiological properties of spinal motoneurones of normal and dystrophic mice.

1975 • 112 citations

Neuromuscular Function and Disorders

1977 • 109 citations

Functional Studies of Regenerated Muscles from Normal and Dystrophic Mice

1971 • 108 citations

Electrophysiological study of dystrophia myotonica

1971 • 107 citations

Reversal of the Enzyme Profiles of Muscle Fibres in Fast and Slow Muscles by Cross-innervation

1966 • 107 citations

AXON‐SCHWANN CELL RELATIONSHIPS IN NEUROPATHIES OF MUTANT MICE *

1979 • 105 citations

Becker‐type muscular dystrophy

1978 • 102 citations

Formation and elimination of foreign synapses on adult salamander muscle

1978 • 100 citations

THE CENTRAL NERVOUS SYSTEM IN DUCHENNE MUSCULAR DYSTROPHY

1969 • 99 citations

Denervated muscle fibres in hereditary mouse dystrophy.

1967 • 97 citations

Central nervous system involvement in progressive muscular dystrophy.

1980 • 95 citations

Motor and sensory nerve conduction velocity in the baboon: normal values and changes during acrylamide neuropathy

1971 • 93 citations

Benign spinal muscular atrophy arising in childhood and adolescence

1967 • 93 citations

An electrophysiological study of Duchenne dystrophy

1971 • 90 citations

The development and significance of the cell columns in the ventral horn of the cervical and upper thoracic spinal cord of the rabbit.

1941 • 88 citations

Muscle membrane protein kinase in myotonic muscular dystrophy

1974 • 84 citations

SUBCLINICAL POLYNEUROPATHY IN RENAL INSUFFICIENCY

1964 • 82 citations

SCAPULOPERONEAL MUSCULAR ATROPHY

1965 • 82 citations

AXOPLASMIC FLOW IN AXONAL NEUROPATHTES II. AXOPLASMIC FLOW IN MICE WITH MOTOR NEURON DISEASE ANT MUSCULAR DYSTROPHY

1973 • 80 citations

The effect of the destruction of peripheral areas on the differentiation of the neuroblasts

1910 • 80 citations

A new method for the estimation of the number of motor units in a muscle: 1. Control subjects and patients with myasthenia gravis

1974 • 76 citations

Mechanical properties of dystrophic mouse muscle

1971 • 72 citations

Muscle hypertrophy after partial denervation: a human case.

1978 • 71 citations

Molecular aspects of the trophic influence of nerve on muscle

1983 • 70 citations

Motor unit size in muscular dystrophy, a macro EMG and scanning EMG study.

1983 • 68 citations

An electrophysiological investigation of limb-girdle and facioscapulohumeral dystrophy

1971 • 65 citations

The virus, the nerve cell, and paralysis; a study of experimental poliomyelitis in the spinal cord.

1948 • 63 citations

Chimaera mouse study shows absence of disease in genetically dystrophic muscle

1974 • 61 citations

Relationship of spontaneous fibrillation potentials to muscle fibre segmentation in human muscular dystrophy

1975 • 61 citations

A preparation for studying dystrophic avian muscle and neuromuscular junctions

1982 • 58 citations

An electromyographic diagnostic screening test in McArdle's disease and a case report

1967 • 56 citations

Histochemistry of the Myotonic Disorders

1966 • 56 citations

New methods of estimating the number of motor units in a muscle.

1976 • 56 citations

Myelinated nerve fibre counts in the nerves of normal and dystrophic mouse muscle

1972 • 54 citations

Electrophysiological estimation of motor units in Duchenne muscular dystrophy

1974 • 54 citations

THE HISTOLOGY OF THE NEUROMUSCULAR JUNCTION IN DYSTROPHIA MYOTONICA

1961 • 54 citations

Terminal Innervation Ratio in Neuromuscular Disease

1973 • 54 citations

Peripheral Nerve Morphometry in Myotonic Dystrophy

1976 • 53 citations

The motor unit profile of the rat soleus in experimental myopathy and reinnervation

1974 • 53 citations

Hypothesis: Duchenne dystrophy viewed as a disturbance of nerve-muscle interactions

1983 • 49 citations

Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice

1974 • 47 citations

The motor unit in muscular dystrophy, a single fibre EMG and scanning EMG study.

1983 • 46 citations

New method for the estimation of the number of motor units in a muscle: 2. Duchenne, limb-girdle and facioscapulohumeral, and myotonic muscular dystrophies

1974 • 46 citations

FACTORS THAT INFLUENCE THE PHENOTYPIC EXPRESSION OF GENETICALLY NORMAL AND DYSTROPHIC MUSCLES *

1979 • 45 citations

Myopathies in Animals

1951 • 45 citations

THE EARLY DETECTION OF DYSTROPHIA MYOTONICA

1972 • 45 citations

Neonatal Myotubular Myopathy: Neuropathy and Failure of Postnatal Maturation of Fetal Muscle

1981 • 44 citations

Nonequivalence of surgical and natural denervation in dystrophic mouse muscles

1972 • 43 citations

Competition between foreign and original nerves in adult mammalian skeletal muscle

1979 • 41 citations

Mental retardation in patients with Duchenne progressive muscular dystrophy

1971 • 41 citations

The Molecular Basis of Development

1985 • 40 citations

Axoplasmic flow of phospholipids and cholesterol in the sciatic nerve of normal and dystrophic mice

1974 • 40 citations

A study of action potential generation in murine dystrophy with reference to “functional denervation”

1973 • 39 citations

Dystrophic mice show age related muscle fibre and myelinated axon losses

1977 • 37 citations

Spinal cord limb motor neurones in muscular dystrophy

1974 • 37 citations

Compartmental relationships between anuran primary spinal motoneurons and somitic muscle fibers that they first innervate

1983 • 36 citations

Beneficial effects of transplanting normal limb‐bud mesenchyme into dystrophic mouse muscles

1982 • 35 citations

Muscular dystrophy and other inherited diseases of skeletal muscle in animals

1979 • 35 citations

Multiple Muscle Analysis of Motor Units in Muscular Dystrophy

1974 • 34 citations

Myogenic Defect in Acetylcholinesterase Regulation in Muscular Dystrophy of the Chicken

1975 • 34 citations

Transplantation of skeletal muscle in normal and dystrophic mice

1975 • 33 citations

MUSCULAR DYSTROPHY IN THE MOUSE: NEUROMUSCULAR TRANSMISSION AND THE CONCEPT OF FUNCTIONAL DENERVATION *

1979 • 31 citations

Evidence for reversible motoneurone dysfunction in thyrotoxicosis

1974 • 29 citations

Postpoliomyelitis muscle pseudohypertrophy

1985 • 28 citations

A Study of Denervated Muscle in Normal and Dystrophic Mice

1959 • 28 citations

56K fibroblast protein not specific for Duchenne muscular dystrophy but for skin biopsy site

1983 • 27 citations

Contrasting effects of suspension on hind limb muscles in the hamster

1984 • 27 citations

Muscle-nerve transplants. Experimental models to study influences on differentiation.

1973 • 27 citations

The absence of dystrophic characteristics in normal muscles successfully cross-reinnervated by nerves of dystrophic genotype: Physiological and cytochemical study of crossed solei of normal and dystrophic parabiotic mice

1976 • 26 citations

Muscle size and motor unit survival in mice.

1984 • 26 citations

Dystrophic spinal cord transplants induce abnormal thymidine kinase activity in normal muscles

1975 • 26 citations

Physiological estimates of the sizes and the numbers of motor units in soleus muscles of dystrophic mice

1975 • 25 citations

Homotransplantation of dystrophic and normal muscle.

1965 • 25 citations

Computer method for the analysis of evoked motor unit potentials: 1. Control subjects and patients with myasthenia gravis

1974 • 25 citations

Causes of the increased fiber density in muscular dystrophies studied with single fiber EMG during electrical stimulation

1985 • 25 citations

Infantile centronuclear myopathy

1983 • 23 citations

Experimentally induced myelination of amyelinated axons in dystrophic mice

1975 • 23 citations

Incidence, severity, and time-course of motoneurone dysfunction in myotonic dystrophy: their significance for an understanding of anticipation.

1978 • 23 citations

Automatic Quantitative Analysis of the Electromyogram in Partially Denervated Distal Muscles: Comparison with Motor Unit Counting

1978 • 22 citations

Effect of denervation on the resting membrane potential of healthy and dystrophic muscle.

1965 • 22 citations

Parabiotic reinnervation in normal and dystrophic mice

1975 • 21 citations

Hypophysectomy mitigates skeletal muscle fiber damage in hamster dystrophy

1985 • 21 citations

Nervous system involvement in progressive muscular dystrophy.

1968 • 20 citations

Further observations on myelinated axon numbers in normal and dystrophic mice

1978 • 19 citations

Transcriptional diversity in myogenesis

1976 • 19 citations

Contractile properties of muscles in myotonic dystrophy.

1983 • 19 citations

Electrophysiological estimation of motor units in limb-girdle muscular dystrophy and chronic spinal muscular atrophy

1975 • 18 citations

Reinnervation is followed by necrosis in previously denervated skeletal muscles of dystrophic hamsters

1983 • 17 citations

Electrophysiological and anatomical estimation of the number of motor units in the monkey extensor digitorum brevis muscle.

1977 • 17 citations

Effects of crush injury on the abnormalities in the spinal roots and peripheral nerves of dystrophic mice

1983 • 16 citations

The number and size of motoneurons in the soleus motor nucleus of the normal and dystrophic (C57BL/6J dy2J/dy2J) mouse

1982 • 15 citations

Further motor unit studies in Duchenne muscular dystrophy.

1977 • 15 citations

The secretory characteristics of dehydrocholate in the dog: comparison with the natural bile salts.

1976 • 15 citations

Sciatic cross-reinnervation of normal and dystrophic muscle in parabiotic mice: Isometric contractile responses of reinnervated tibialis anticus and triceps surae

1975 • 15 citations

Fluctuation in the development of various skeletal muscles in the chick embryo, with special reference to AChE activity and the formation of neuromuscular junctions

1983 • 13 citations

Motor units in a fast‐twitch muscle of normal and dystrophic mice.

1983 • 13 citations

A study of functional denervation in fast and slow muscles of dystrophic mice of various ages

1977 • 12 citations

MOSAIC ANALYSIS OF DYSTROPHIC↔NORMAL CHIMERAS: AN APPROACH TO MAPPING THE SITE OF GENE EXPRESSION*

1979 • 11 citations

Reinnervation in duchenne muscular dystrophy

1983 • 11 citations

Contribution of the Na⁺‐K⁺ pump to membrane potential in familial periodic paralysis

1985 • 11 citations

PROGRESSIVE DENERVATION OF SKELETAL MUSCLE INDUCED BY SPINAL IRRADIATION IN RATS

1977 • 10 citations

Myofiber differentiation in normal and hypotrophied canine pectineal muscles

1982 • 10 citations

Thymidine phosphorylation and thymidylate kinase in developing breast muscle of normal and dystrophic chickens

1971 • 9 citations

Ulnar Neuropathies In Rheumatoid Arthritis

1978 • 9 citations

Rate and extent of functional reinnervation in fast-twitch and slow-twitch muscles of the dystrophic mouse (C57Bl6Jdy2jdy2j)

1981 • 9 citations

Neuropathy in McArdle's Syndrome

1973 • 8 citations

Neuromuscular function in limb girdle dystrophy.

1985 • 7 citations

Absence of fibrillation after muscle injury

1983 • 6 citations

[Muscular disease of X-linked autosomal recessive transmission with early muscular retractions and cardiac conduction disorders].

1982 • 6 citations

ROLE OF THE NEURAL TUBE IN THE PATHOGENESIS OF HEREDITARY MUSCULAR DYSTROPHY IN THE CHICKEN: STUDIES WITH TRANSPLANTATION CHIMERAS *

1979 • 4 citations

Structure of motor nerve terminals in chickens with hereditary muscular dystrophy

1985 • 4 citations

Duchenne-type dystrophy: selective aspects of diagnosis and management.

1966 • 1 citations